?-Laktamasen mit breitem Wirkungsspektrum

Witte, Wolfgang; Mielke, Martin

doi:10.1007/s00103-003-0693-3

Cited by 18 publications

(4 citation statements)

References 29 publications

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“…As a result, they retain activity against a wide variety of resistant pathogens and this is of importance, as the incidence of resistant strains expressing ESBLs is increasing. [7][8][9][10] Few data are available about the in-hospital experience of clinicians treating sepsis, on their perceived use of carbapenems in sepsis, prescription pattern and clinical outcome with the use of carbapenems in tertiary care hospital for sepsis management. This study was undertaken with the objective of knowing the importance of carbapenems in the management of sepsis focusing on perceived use and the clinical outcome in real time setting in intensive care in and around Mangalore, India.…”

Section: Figure 1: Major Pathogens Isolated From Indian Sepsis Patientsmentioning

confidence: 99%

A questionnaire based survey to evaluate the usage pattern of carbapenems for sepsis management in intensive care unit

Shetty¹,

Vishwaprakash²,

Somashekara³

2016

Int J Basic Clin Pharmacol

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Background: Sepsis remains one of the most common critical illnesses for patients to be admitted to an intensive care unit (ICU) and has very high associated morbidity and mortality ranging from 18 to 50%. It is a well-known fact that early goal directed therapy with broad spectrum antibiotics, IV fluids and other supportive therapies improve outcome. The current study was done to know the importance of carbapenems in the management of sepsis focusing on perceived use and the clinical outcome in real time setting in tertiary care hospitals. Methods: A structured questionnaire designed to collect information on the perceived use of carbapenems, the clinical outcome, response period for clinical cure and combination antibiotic therapy preferred with carbapenem was circulated among 50 clinicians in tertiary care hospitals and nursing homes in and around Mangalore between January 2015 to March 2015. Results: Majority of doctors (>80%) felt that carbapenems a broad spectrum antibiotic administration provided good clinical improvement in hospital infections along with improvement in blood cell count and bacteriological cure. Conclusions:Our study provides an important insight regarding the knowledge, practice pattern and clinical outcome through the use of carbapenem in Sepsis management in ICU's around Mangalore. The experience of practice patterns and clinical outcomes with carbapenem shared by doctors through this survey is similar to that in other studies.

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Section: Figure 1: Major Pathogens Isolated From Indian Sepsis Patientsmentioning

confidence: 99%

A questionnaire based survey to evaluate the usage pattern of carbapenems for sepsis management in intensive care unit

Shetty¹,

Vishwaprakash²,

Somashekara³

2016

Int J Basic Clin Pharmacol

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“…As a consequence, they retain activity against a wide variety of multiply resistant pathogens, especially cephalosporin‐resistant Gram‐negative bacteria. This is of importance, as the incidence of strains expressing ESBLs (and often more than one ESBL per organism) is increasing [5–8]. For example, the Paul‐Ehrlich‐Society’s multicentre survey on resistance, which has been conducted on a regular basis since 1975, reported, for the years 2001 and 2004, ESBL phenotypes in 1.8% and 5.1% of Escherichia coli, in 12.7% and 7.3% of Klebsiella pneumoniae, and in 5.3% and 12.4% of Klebsiella oxytoca isolates, respectively [9].…”

Section: Microbiologymentioning

confidence: 99%

Parenteral carbapenems

Shah

2008

Clinical Microbiology and Infection

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Among the many different structurally distinct classes of beta-lactams, the carbapenem class is regarded as that which is most potent and which has the widest spectrum of antimicrobial activity. Rapidly bactericidal, and demonstrating time-dependent killing, carbapenemes have a spectrum of antimicrobial activity that includes Gram-positive and Gram-negative aerobic and anaerobic pathogens. Their in-vitro activity includes extended-spectrum beta-lactamase (ESBL)-producing pathogens and carbapenems are currently considered to be the treatment of choice for serious infections due to ESBL-producing organisms. However, isolates acquiring resistance under treatment have been reported. Imipenem, meropenem and ertapenem are licensed in the European Community and panipenem and biapenem are also available in Japan and South Korea. Other carbapenemes are under development.

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“…Note however that the PEG-study in 2001 already revealed a cefotaxim-resistance rate of 11% for Klebsiella pneumoniae. We know from countries in which Enterobacteriaceae with ESBL occurred much earlier that K. pneumonia was always effected first and acted as a reservoir for the b-lactamase genes and resistance plasmids, followed by E. coli later on (Witte and Mielke, 2003).…”

mentioning

confidence: 99%

Resistance monitoring of human pathogenic bacteria, SWOT analysis and examples

Witte

2006

International Journal of Medical Microbiology

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?-Laktamasen mit breitem Wirkungsspektrum

Cited by 18 publications

References 29 publications

A questionnaire based survey to evaluate the usage pattern of carbapenems for sepsis management in intensive care unit

A questionnaire based survey to evaluate the usage pattern of carbapenems for sepsis management in intensive care unit

Parenteral carbapenems

Resistance monitoring of human pathogenic bacteria, SWOT analysis and examples

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