Lamellar–micelle transition in a hydrogel induced by polyethylene glycol grafting

Haque, Md. Anamul; Kurokawa, Takayuki; Gong, Jian Ping

doi:10.1039/c3sm50544h

Cited by 6 publications

(4 citation statements)

References 26 publications

(59 reference statements)

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“…The obtained results are in line with previous reports indicating an inverse relationship between the E‐modulus and hydrogel swelling (see Figures and for comparison) . Hydrogels with lower E‐modulus are typically characterized by more flexible polymer chains, which result in higher swelling capacity.…”

Section: Discussionsupporting

confidence: 92%

pH‐Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds

Koehler

Wallmeyer

Hedtrich

et al. 2016

Macromolecular Bioscience

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The development of chronic wounds has been frequently associated with alkaline pH values. The application of pH-modulating wound dressings can, therefore, be a promising treatment option to promote normal wound healing. This study reports on the development and characterization of acidic hydrogel dressings based on interpenetrating poly(ethylene glycol) diacrylate/acrylic acid/alginate networks. The incorporation of ionizable carboxylic acid groups results in high liquid uptake up to 500%. The combination of two separate polymer networks significantly improves the tensile and compressive stability. In a 2D cell migration assay, the application of hydrogels (0% to 1.5% acrylic acid) results in complete "wound" closure; hydrogels with 0.25% acrylic acid significantly increase the cell migration velocity to 19.8 ± 1.9 µm h . The most promising formulation (hydrogels with 0.25% acrylic acid) is tested on 3D human skin constructs, increasing keratinocyte ingrowth into the wound by 164%.

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Section: Discussionsupporting

confidence: 92%

pH‐Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds

Koehler

Wallmeyer

Hedtrich

et al. 2016

Macromolecular Bioscience

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“…The modulus of PAAm gel layer ( E A ) in PDGI/PAAm gels at various water contents was calculated from the bulk modulus E of the hybrid gel shown in Figure a using eq . In the calculation, the modulus ( E D ) and thickness ( h D ) of single PDGI bilayer were fixed as ∼5 MPa and ∼4.7 nm, respectively, according to the literature . The thickness of PAAm gel layer ( h A ) was estimated from the interlamellar distance d , where d was determined from the reflection spectra or the SAXD result.…”

Section: Discussionmentioning

confidence: 99%

“…In the calculation, the modulus (E D ) and thickness (h D ) of single PDGI bilayer were fixed as ∼5 MPa and ∼4.7 nm, respectively, according to the literature. 29 The thickness of PAAm gel layer (h A ) was estimated from the interlamellar distance d, where d was determined from the reflection spectra or the SAXD result.…”

Section: Discussionmentioning

confidence: 99%

Water-Triggered Ductile–Brittle Transition of Anisotropic Lamellar Hydrogels and Effect of Confinement on Polymer Dynamics

Ilyas¹,

Haque

Yue³

et al. 2017

Macromolecules

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We study the effect of dehydration on the structure and mechanical properties of anisotropic lamellar hydrogels, consisting of alternative stacking of several thousands of nanoscale rigid bilayers from amphiphilic poly(dodecyl glyceryl itaconate) (PDGI) and submicroscale soft hydrogel layers from hydrophilic polyacrylamide (PAAm) networks. We found that the layered microstructure is well preserved with dehydration, and a ductile–brittle transition occurs at the critical water content. This transition is related to the rubbery–glassy transition of the PAAm layers, which occurs at 58 wt % water content and is much higher than 26 wt % of bulk PAAm hydrogels. Such specific behavior of the lamellar hydrogels indicates that the dynamics of the submicroscale PAAm hydrated layer intercalated between the rigid bilayers are very different from its bulk state.

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“…As the PDGI layers and PAAm networks adhere via hydrogen bonding [ 17 ], the deformations of the PAAm network and PDGI bilayers are well coupled. Owing to their periodic and well-oriented lamellar structure, PDGI/PAAm gels exhibit unique properties such as anisotropic swelling [ 14 , 18 ], anisotropic deformation [ 19 ], stimuli-responsive structure color [ 20 , 21 ], low-dimensional diffusion [ 18 , 22 ], and high mechanical toughness [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Model for Super-Anisotropic Swelling of the Multi-Cylindrical PDGI/PAAm Gels

2023

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MC-PDGI/PAAm gels are cylindrical composite gels containing poly(dodecyl glyceryl itaconate) (PDGI) as a polymerized lipid oriented in a multilayer tubular shape within a polyacrylamide (PAAm) network. The most unique feature of the MC-PDGI/PAAm gel is its super-anisotropic swelling, wherein the diameter of the gel increases, but the length decreases with an increase in the volume of the gel. Through swelling and small-angle X-ray diffraction experiments, we investigated the effects of PDGI lipid bilayers and polymer network on the swelling of the MC-PDGI/PAAm gel, which suggests that the swelling anisotropy of the MC-PDGI/PAAm gel is dominated by the elasticity of the PDGI bilayers. Furthermore, we investigated the equation of state of the gel that roughly reproduced the experimental swelling results. These findings are crucial for realizing the controlled super-anisotropic swelling of MC-PDGI/PAAm gels and their applications as anisotropic actuation devices.

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Lamellar–micelle transition in a hydrogel induced by polyethylene glycol grafting

Cited by 6 publications

References 26 publications

pH‐Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds

pH‐Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds

Water-Triggered Ductile–Brittle Transition of Anisotropic Lamellar Hydrogels and Effect of Confinement on Polymer Dynamics

Mechanical Model for Super-Anisotropic Swelling of the Multi-Cylindrical PDGI/PAAm Gels

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