Laminar and Prelaminar Tissue Displacement During Intraocular Pressure Elevation in Glaucoma Patients and Healthy Controls

Agoumi, Younes; Sharpe, Glen P.; Hutchison, Donna M.; Nicolela, Marcelo T.; Artes, Paul H.; Chauhan, Balwantray C.

doi:10.1016/j.ophtha.2010.05.016

Cited by 188 publications

(169 citation statements)

References 48 publications

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“…Agoumi et al 16 have previously reported the opposite ONH changes after acute IOP elevation (compression of prelaminar tissue with limited posterior displacement of LC), which supports the same hypothesis.…”

Section: Discussionsupporting

confidence: 57%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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Aim To determine the response of the lamina cribrosa (LC) and prelaminar tissue to a reduction of intraocular pressure (IOP) after nonpenetrating deep sclerectomy (NPDS) using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods A total of 28 eyes from 28 patients presenting with primary open angle glaucoma who underwent NPDS were studied. SD-OCT scans using EDI technology were obtained before surgery and 1 week, 1 month, and 3 months postoperatively. The OCT device was set to image a 15 Â 101 vertical rectangle centred on the optic disc. The scan closest to the optic nerve head (ONH) centre was selected for analysis. The vertical distances from three equidistant points on the reference line (Bruch's membrane opening) to the anterior prelaminar tissue surface and the anterior and posterior surfaces of the LC were measured. Results The IOP decreased from 18.7 ± 4.3 to 9.1±4.0 at the first week, 11.4±3.7 at 1 month, and 13.1±3.6 mm Hg at 3 months postoperatively (Po0.001). There was a significant reduction of the ONH cupping at 1 week (22.3%, Po0.001), 1 month (13.7%, Po0.001), and 3 months (9.8%, P ¼ 0.001) after surgery. Anterior displacement of the LC was slight but statistically significant at 1 week (4.5%, P ¼ 0.003), 1 month (3.8%, P ¼ 0.014), and 3 months postoperatively (3.3%, P ¼ 0.010). IOP reduction was significantly correlated with a reduction of ONH cupping and anterior displacement of LC at the first week and first month (Po0.05). Conclusions Cupping reversal after NPDS is mainly due to changes in prelaminar tissue thickness, whereas the LC changes in position are less pronounced.

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Section: Discussionsupporting

confidence: 57%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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“…On the other hand, Agoumi et al described displacement of only the prelaminar tissue after transient elevation of IOP with an ophthalmodynamometer. 20 The very different circumstances of acute IOP elevation in the Agoumi study and long-term IOP reduction in our study can explain these discrepancies. Furthermore, Agoumi et al suggested that this displacement was the result of the inner limiting membrane and prelaminar tissue compression.…”

Section: Fig 2 Oct Scan Showing a Clear View Of The Lamina Cribrosacontrasting

confidence: 51%

“…12,26 Additionally, Lee et al observed that the decrease in the scleral canal diameter was significantly associated with the reversal of the LC displacement after trabeculectomy, whereas a larger scleral preoperative canal diameter was associated with a greater ONH tissue displacement. 12 In contrast to other studies 6,12,20 that segmented the LC, the entire LC was clearly visible in only nine eyes, despite the Data presented as mean -standard deviation, where applicable.…”

Section: Discussionmentioning

confidence: 58%

“…15,20 It has been shown that mechanical stress and possible deformation of the LC can have a deleterious effect on axonal functioning. 21,22 Furthermore, anterior displacement of prelaminar tissue following trabeculectomy for OAG has been described in a number of studies with variable results.…”

Section: Discussionmentioning

confidence: 99%

“…A straight reference line (RL) was drawn by one investigator (AR) masked to scan order between opposite edges of the opening in Bruch's membrane. 6,7,12,20 For study purposes, the cup area was defined as the cross-sectional optic disc area circumscribed by the RL (vitreal side) and the prelaminar tissue (toward the LC). Then, the uniformly dark area was automatically identified by Photoshop using the Color Selection tool with a tolerance of eight ( Fig.…”

Section: Image and Data Analysismentioning

confidence: 99%

See 2 more Smart Citations

Topographic Optic Disc Changes After Successful Trabeculectomy Evaluated Using Spectral Domain Optical Coherence Tomography

Russo

Katsanos

Riva

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To investigate topographic optic disc changes after surgical intraocular pressure (IOP) reduction in adults with open angle glaucoma (OAG). Methods: Optic discs of patients with advanced primary open angle or exfoliation glaucoma were imaged using optical coherence tomography within 1 week before trabeculectomy. Patients were rescanned 1 week, 1 month, and 1 year after surgery. Maximum cup depth (MCD), and average cup depth (ACD) were calculated. Results: Twenty-two eyes from 20 patients (age, 70.5 -10.6 years; average mean defect of visual field, -15.0 -9.8 dB) were followed up for 1 year. The IOP decreased from 22.1 -2.8 mmHg at baseline to 11.5 -2.6 mmHg 1 year following surgery (P < 0.001). One-week and 1-month postoperative IOPs were 11.2 -2.8 and 11.2 -3.5 mmHg, respectively (P < 0.001). Compared to the baseline values (356 -172 mm), postoperative ACD showed a significant decrease at 1 week (312 -164 mm; P < 0.001) and 1 month (338 -175 mm; P = 0.007) after surgery, but not at 1 year (339 -176 mm; P = 0.354). Similarly, MCD significantly decreased from baseline (477 -190 mm) 1 week (431 -203 mm; P = 0.029) and 1 month (448 -198 mm; P = 0.047) after the surgery, but not after 1 year (479 -188 mm; P = 1.0). Conclusions: Trabeculectomy reduces IOP in eyes with advanced OAG, which induces topographic optic disc changes. Such optic disc changes became less pronounced over time and were no longer detectable 1 year after surgery.

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