2002
DOI: 10.1006/nlme.2001.4045
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Laminar-Dependent Dendritic Spine Alterations in the Motor Cortex of Adult Rats Following Callosal Transection and Forced Forelimb Use

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Cited by 43 publications
(26 citation statements)
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“…41 Forced use of the limb or callosal transection alone result in only subtle changes in dendrites. 42 Similar conclusions can be reached regarding contralesional synaptogenesis. 43 Other studies have demonstrated that task-specific rehabilitative training is most effective in driving post-injury neuroanatomical changes.…”
Section: Modulating Neuroplasticity After Strokesupporting
confidence: 67%
“…41 Forced use of the limb or callosal transection alone result in only subtle changes in dendrites. 42 Similar conclusions can be reached regarding contralesional synaptogenesis. 43 Other studies have demonstrated that task-specific rehabilitative training is most effective in driving post-injury neuroanatomical changes.…”
Section: Modulating Neuroplasticity After Strokesupporting
confidence: 67%
“…In contrast to FosB/ΔFosB expression in layer II/III, neuronal labeling in layer V was not sensitive to the effects of intact forelimb training, though it was increased by the lesions alone. Both layers receive callosal projections (Donoghue and Parham, 1983), but dendritic spines in layer II/III are particularly responsive to manipulations of forelimb experience in intact rats (Adkins, Bury, and Jones, 2002). It may be that a greater duration of intact forelimb training is needed to influence FosB/ ΔFosB expression in layer V. In intact adult rats, 28 days of training on a complex motor skills task, the acrobatic task, increased layer V synapses per neuron .…”
Section: Discussionmentioning
confidence: 99%
“…31 The trend for increased FosB/DFosB expression in the contralesional forelimb motor cortex occurred predominantly in layer II/III, which has been shown to be sensitive to manipulation in forelimb use. 32 Previous studies have shown that motor learning can increase synaptic density of both layers II/III 33 and V. 34 It is possible that more intense motor activity or longer treatment duration is required to increase FosB/DFosB expression in layer V, or alternatively that other mechanisms are involved in the dendritic remodeling that has been observed in that layer after prolonged rehabilitation. 3,4 Regardless, the increased neuronal activation in the contralesional cortex after 10 days of ER, although not statistically significant, is consistent with the notion that the intact hemisphere is involved in recovery processes.…”
Section: Discussionmentioning
confidence: 99%