2020
DOI: 10.3390/md18070345
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Laminarin Attenuates Ultraviolet-Induced Skin Damage by Reducing Superoxide Anion Levels and Increasing Endogenous Antioxidants in the Dorsal Skin of Mice

Abstract: A number of studies have demonstrated that marine carbohydrates display anti-oxidant, anti-melanogenic, and anti-aging activities in the skin. Laminarin (LA), a low-molecular-weight polysaccharide, is found in brown algae. The benefits of LA in ultraviolet B (UVB) induced photodamage of the skin have not been reported. The aim of this study was to investigate the effects of pre-treated LA on histopathological changes and oxidative damage in mouse dorsal skin on day 5, following repeated UVB exposure. H… Show more

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Cited by 33 publications
(18 citation statements)
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“…Exposure to ultraviolet (UVB) radiation induces skin damage including erythema, excoriation, dryness, and crust formation [ 1 , 2 ]. UVB radiation causes photodamage primarily through reactive oxygen species (ROS) produced in the epidermis [ 3 , 4 ]. ROS induces secretion of matrix metalloproteinases (MMPs; MMP-1, -2, -3, -9, and -13) from fibroblasts and keratinocytes, which in turn degrade collagen and other extracellular matrix (ECM) proteins, impair collagen synthesis, and cause skin photodamage [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Exposure to ultraviolet (UVB) radiation induces skin damage including erythema, excoriation, dryness, and crust formation [ 1 , 2 ]. UVB radiation causes photodamage primarily through reactive oxygen species (ROS) produced in the epidermis [ 3 , 4 ]. ROS induces secretion of matrix metalloproteinases (MMPs; MMP-1, -2, -3, -9, and -13) from fibroblasts and keratinocytes, which in turn degrade collagen and other extracellular matrix (ECM) proteins, impair collagen synthesis, and cause skin photodamage [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Lately, sunblock products are in great request for protection against UVB exposure, and the radioprotective effects of numerous materials including natural resources have been studied [ 4 , 23 , 24 ]. However, effects on skin aging and photodamage of Aronia melanocarpa have been poorly reported.…”
Section: Introductionmentioning
confidence: 99%
“…The laminarin treatment significantly increased the thickness of dermis, tissue inhibitor MMP-1 (TIMP-1) level, and decreased the expression and release of MMP-1 [ 92 ]. It also protected mouse dorsal skin from UVB induced photodamage [ 93 ]. Furthermore, it significantly increased collagen fibers in the dermis of the UVB treated ICR mice.…”
Section: Seaweed Compounds As Potential Sources Of Anti-photoagingmentioning
confidence: 99%
“…Polysaccharides have various brown, red, and green characteristics. Some important seaweed polysaccharides that have commercial value are fucoidan, alginates, and laminarin from brown algae; carrageenan and agar from red, and ulvan from green seaweeds [ 36 , 42 , 43 , 44 , 45 , 46 , 47 ].…”
Section: Polysaccharides From Seaweedsmentioning
confidence: 99%