Laminarin based AgNPs using brown seaweed<i>Turbinaria ornata</i>and its induction of apoptosis in human retinoblastoma Y79 cancer cell lines

Remya, R.R.; Rajasree, S.R. Radhika; Suman, Thodhal Yoganandham; Aranganathan, L.; Gayathri, S.; Gobalakrishnan, M.; Karthih, M.G.

doi:10.1088/2053-1591/aab2d8

Cited by 31 publications

(17 citation statements)

References 37 publications

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“…At 5.6 μg/mL, the biosynthesized AgNPs induced DNA fragmentation, cell cycle arrest at the G2/M phase, upregulation of Bax and caspase-3 and downregulation of Bcl-2 [50]. A similar DNA fragmentation result was reported by Reya et al 2018, who evaluated the DNA damage of algal-based AgNPs (21–34 nm) at 10–50 μg/mL against the Y79 cell line [51]. Moteriya et al 2018 investigated the genotoxicity of phytosynthesized AgNPs with an average size of 8 nm against normal human lymphocytes.…”

Section: Discussionmentioning

confidence: 54%

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

et al. 2019

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Background and objectives: Although studies have elucidated the significant biomedical potential of biogenic metallic nanoparticles (MNPs), it is very important to explore the hazards associated with the use of biogenic MNPs. Evidence indicates that genetic toxicity causes mutation, carcinogenesis, and cell death. Materials and Methods: Therefore, we systematically review original studies that investigated the genotoxic effect of biologically synthesized MNPs via in vitro and in vivo models. Articles were systematically collected by screening the literature published online in the following databases; Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, and EBSCO. Results: Most of the studies were carried out on the MCF-7 cancer cell line and phytosynthesis was the general approach to MNP preparation in all studies. Fungi were the second most predominant resource applied for MNP synthesis. A total of 80.57% of the studies synthesized biogenic MNPs with sizes below 50 nm. The genotoxicity of Ag, Au, ZnO, TiO2, Se, Cu, Pt, Zn, Ag-Au, CdS, Fe3O4, Tb2O3, and Si-Ag NPs was evaluated. AgNPs, prepared in 68.79% of studies, and AuNPs, prepared in 12.76%, were the two most predominant biogenic MNPs synthesized and evaluated in the included articles. Conclusions: Although several studies reported the antigenotoxic influence of biogenic MNPs, most of them reported biogenic MNP genotoxicity at specific concentrations and with a dose or time dependence. To the best of our knowledge, this is the first study to systematically evaluate the genotoxicity of biologically synthesized MNPs and provide a valuable summary of genotoxicity data. In conclusion, our study implied that the genotoxicity of biologically synthesized MNPs varies case-by-case and highly dependent on the synthesis parameters, biological source, applied assay, etc. The gathered data are required for the translation of these nanoproducts from research laboratories to the clinical market.

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Section: Discussionmentioning

confidence: 54%

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

et al. 2019

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“…Same group researchers (2018) introduced the polysaccharide laminarin into their preformed Ag-NPs and extracted, purified, and analyzed laminarin through Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectroscopy (MALDI-TOF MS) and Proton Nuclear Magnetic Resonance ( 1 H NMR), UV-vis, FTIR, XRD, and TEM. Moreover, free radical scavenging of the formulation was done to evaluate its cytotoxicity against RB cells [ 129 ].…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma

et al. 2021

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Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose, nanotechnology has revolutionized the field of medicine with versatile potential capabilities for both the diagnosis, as well as the treatment, of retinoblastoma via the targeted and controlled delivery of anticancer drugs via binding to the overexpressed retinoblastoma gene. Nanotechnology has also generated massive advancements in the treatment of retinoblastoma based on the use of surface-tailored multi-functionalized nanocarriers; overexpressed receptor-based nanocarriers ligands (folate, galactose, and hyaluronic acid); lipid-based nanocarriers; and metallic nanocarriers. These nanocarriers seem to benchmark in mitigating a plethora of malignant retinoblastoma via targeted delivery at a specified site, resulting in programmed apoptosis in cancer cells. The effectiveness of these nanoplatforms in diagnosing and treating intraocular cancers such as retinoblastoma has not been properly discussed, despite the increasing significance of nanomedicine in cancer management. This article reviewed the recent milestones and future development areas in the field of intraocular drug delivery and diagnostic platforms focused on nanotechnology.

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“…17,19,20,44,64,197−200 Xu et al have recently found that LNT also targets tumors in vivo even after oral or intraperitoneal injection, followed by the promotion of CD4 + T cell immunomodulation and neutrophil infiltration into tumors, finally leading to tumor growth inhibition. 17 Many other triple-helix polysaccharides, such as SPG, 201 β-glucan from dictyophora indusiate, 202 auricularian, 20,203 laminarin, 204,205 yeast glucan, 206 and so on, also show similar antitumor effects. Especially, as introduced above, the triple-helix LNT and SPG, as well as a protein bound β-glucan called PSK (Krestin), which are commercially used clinic antitumor drugs in Japan and some other Asian countries now.…”

Section: Anticancer Activities Of Triple-helix β-13-d-glucansmentioning

confidence: 99%

“…LNT significantly inhibits cancer cells (H22, MCF-7, S-180, HepG2 cells, and so on) growth or remarkably improve the antitumor effects on cancer mice without damage to organisms demonstrated by many experimental results both in vivo and in vitro during the past years. ,,,,,− Xu et al have recently found that LNT also targets tumors in vivo even after oral or intraperitoneal injection, followed by the promotion of CD4 + T cell immunomodulation and neutrophil infiltration into tumors, finally leading to tumor growth inhibition . Many other triple-helix polysaccharides, such as SPG, β-glucan from dictyophora indusiate, auricularian, , laminarin, , yeast glucan, and so on, also show similar antitumor effects.…”

Section: Anticancer Activities Of Triple-helix β-13-d-glucansmentioning

confidence: 99%

Recent Advances in Chain Conformation and Bioactivities of Triple-Helix Polysaccharides

et al. 2020

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Natural polysaccharides derived from renewable biomass sources are regarded as environmentally friendly and sustainable polymers. As the third most abundant biomacromolecule in nature, after proteins and nucleic acids, polysaccharides are also closely related with many different life activities. In particular, β-glucans are one of the most widely reported bioactive polysaccharides and are usually considered as biological response modifiers. Among them, β-glucans with triple-helix conformation have been the hottest and most well-researched polysaccharides at present, especially lentinan and schizophyllan, which are clinically used as cancer therapies in some Asian countries. Thus, creation of these active triple-helix polysaccharides is beneficial to the research and development of sustainable “green” biopolymers in the fields of food and life sciences. Therefore, full fundamental research of triple-helix polysaccharides is essential to discover more applications for polysaccharides. In this Review, the recent research progress of chain conformations, bioactivities, and structure–function relationships of triple-helix β-glucans is summarized. The main contents include the characterization methods of the macromolecular conformation, proof of triple helices, bioactivities, and structure–function relationships. We believe that the governments, enterprises, universities, and institutes dealing with the survival and health of human beings can expect the development of natural bioproducts in the future. Hence, a deep understanding of β-glucans with triple-helix chain conformation is necessary for application of natural medicines and biologics for a sustainable world.

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Laminarin based AgNPs using brown seaweedTurbinaria ornataand its induction of apoptosis in human retinoblastoma Y79 cancer cell lines

Cited by 31 publications

References 37 publications

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma

Recent Advances in Chain Conformation and Bioactivities of Triple-Helix Polysaccharides

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