Laminin‐332 expression in oral lichen planus: Preliminary results of a cross‐sectional study

Akama, Mayara Sayuri Kamimura; Teixeira, Lucas Ribeiro; Innocentini, Lara Maria Alencar Ramos; Gallo, Camila de Barros; Pinheiro, Tiago Novaes; Ribeiro‐Silva, Alfredo; Motta, Ana Carolina Fragoso

doi:10.1111/odi.13612

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…O evento de transformação maligna ocorreu apenas em LL, sendo que de 3 amostras que sofreram malignização 2 foram positivas para a laminina-332, sustentando a hipótese de que este pode ser um importante marcador na previsão de malignidade em tais lesões. Estudos semelhantes são relevantes e devem ser incentivados para que se possa detectar precocemente lesões malignas 10 .…”

Section: Caso Clínicounclassified

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Vírus da Hepatite B e Câncer Bucal: Existe Alguma Relação?

Andrade Araujo,

Cabral,

Pinheiro

et al. 2021

Arch Health Invest

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Dentre as neoplasias malignas da cavidade oral, o carcinoma espinocelular (CEC) é a mais comum delas e embora seja um evento raro, pode se originar a partir de lesões cancerizáveis, como o líquen plano oral (LPO) e lesões liquenóides (LL). Tais lesões, assim como o CEC estão possivelmente associadas ao vírus da hepatite C (VHC). Sabe-se que o vírus da hepatite B (VHB) está intimamente ligado ao desenvolvimento do carcinoma hepatocelular, no entanto são escassos os estudos sobre os fenômenos do vírus sobre o epitélio oral. Em razão dos resultados de pesquisas sobre a cancerização dessas lesões serem variáveis e não consensuais, considera-se a existência de outros possíveis fatores de risco ainda não explorados pela ciência. O presente trabalho relata caso de paciente do sexo masculino, 67 anos, com sorologia positiva para VHB e histórico de tabagismo e etilismo, abstêmio há 2 e 10 anos, respectivamente, queixando-se de lesão nodular em soalho bucal e com diagnóstico anterior de lesão liquenóide, que foi tratada com corticoide tópico e cessão do tabagismo e do uso das próteses totais. Ao exame intraoral foi identificada lesão exofítica extensa em soalho bucal, que submetida a biópsia incisional, teve diagnóstico de carcinoma espinocelular basaloide (CEB), uma variante histológica rara do CEC. O paciente foi submetido a tratamento cirúrgico, radio e quimioterápico. Consideramos que a infecção crônica pelo VHB, poderia constituir um fator de risco para a cancerização do LPO e LL através dos efeitos que produtos da replicação viral têm sobre a regulação da proliferação celular.

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Section: Caso Clínicounclassified

“…Ainda nesse estudo, foi sustentada a hipótese de que a transformação maligna ocorre somente em LL. A biópsia é indicada em lesões que apresentem mudanças nas características clínicas ou evolução rápida para descartar a possibilidade de transformação maligna 5,10 .…”

Section: Introductionunclassified

Vírus da Hepatite B e Câncer Bucal: Existe Alguma Relação?

Andrade Araujo,

Cabral,

Pinheiro

et al. 2021

Arch Health Invest

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“…However, some studies interested in this topic [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ] constitute primary-level studies that consequently provide a limited level of evidence. This is the reason for this scoping review of systematic reviews and meta-analyses that aims to present the current knowledge on the expression of the cancer hallmarks [ 2 ] in OLP based on the evidence, with the objective of pointing out evidence gaps [ 36 , 37 ], proposing new lines of research, and achieving a better understanding of the molecular mechanisms involved in OLP and its malignization, which will allow the design of strategies applicable to its prevention.…”

Section: Introductionmentioning

confidence: 99%

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

González‐Moles

Pino

Ramos‐García

2022

IJMS

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Oral lichen planus (OLP) is a common chronic inflammatory disease of unknown etiology and likely autoimmune nature that is currently considered an oral potentially malignant disorder, implying that patients suffering from this process are at risk of developing oral cancer in their lifetime. The molecular alterations that develop in OLP and that make the affected oral epithelium predisposed to malignancy are unknown, although, as in other autoimmune diseases (ulcerative colitis, primary biliary cirrhosis, etc.), they may be linked to oncogenesis-promoting effects mediated by the inflammatory infiltrate. So far there is no in-depth knowledge on how these hallmarks of cancer are established in the cells of the oral epithelium affected by OLP. In this scoping review of systematic reviews and meta-analyses the state of evidence based knowledge in this field is presented, to point out gaps of evidence and to indicate future lines of research. MEDLINE, Embase, Cochrane Library and Dare were searched for secondary-level studies published before October 2022. The results identified 20 systematic reviews and meta-analyses critically appraising the hallmarks tumor-promoting inflammation (n = 17, 85%), sustaining proliferative signaling (n = 2, 10%), and evading growth suppressors (n = 1, 5%). No evidence was found for the other hallmarks of cancer in OLP. In conclusion, OLP malignization hypothetically derives from the aggressions of the inflammatory infiltrate and a particular type of epithelial response based on increased epithelial proliferation, evasion of growth-suppressive signals and lack of apoptosis. Future evidence-based research is required to support this hypothesis.

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A Molecular Hypothesis on Malignant Transformation of Oral Lichen Planus: A Systematic Review and Meta-Analysis of Cancer Hallmarks Expression in This Oral Potentially Malignant Disorder

Keim-del Pino,

Ramos-García,

González-Moles

2024

Cancers

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We aimed to qualitatively and quantitatively analyze, through a systematic review and meta-analysis, the current evidence on the differential expression of the hallmarks of cancer in oral lichen planus (OLP) samples, in order to know the earliest molecular mechanisms that could be involved in the malignant transformation of this oral potentially malignant disorder. We searched MEDLINE/PubMed, Embase, Web of Science, and Scopus for studies published before November 2023. We evaluated the methodological quality of studies and carried out meta-analyses to fulfill our objectives. Inclusion criteria were met by 110 primary-level studies, with 7065 OLP samples, in which the expression of 104 biomarkers were analyzed through immunohistochemistry. Most OLP samples showed sustained cell proliferation signaling (65.48%, 95%CI = 51.87–78.02), anti-apoptotic pathways (55.93%, 95%CI = 35.99–75.0), genome instability (48.44%, 95%CI = 13.54–84.19), and tumor-promoting inflammation events (83.10%, 95%CI = 73.93–90.74). Concurrently, OLP samples also harbored tumor growth suppressor mechanisms (64.00%, 95%CI = 53.27–74.12). In conclusion, current evidence indicates that molecular mechanisms promoting hyperproliferative signaling, an antiapoptotic state with genomic instability, and an escape of epithelial cells from immune destruction, are developed in LP-affected oral mucosa. It is plausible that these events are due to the actions exerted by the chronic inflammatory infiltrate. Malignant transformation appears to be prevented by tumor suppressor genes, which showed consistent upregulation in OLP samples.

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Laminin‐332 expression in oral lichen planus: Preliminary results of a cross‐sectional study

Cited by 3 publications

References 21 publications

Vírus da Hepatite B e Câncer Bucal: Existe Alguma Relação?

Vírus da Hepatite B e Câncer Bucal: Existe Alguma Relação?

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

A Molecular Hypothesis on Malignant Transformation of Oral Lichen Planus: A Systematic Review and Meta-Analysis of Cancer Hallmarks Expression in This Oral Potentially Malignant Disorder

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