1992
DOI: 10.1002/j.1460-2075.1992.tb05553.x
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Laminin A chain: expression during Drosophila development and genomic sequence.

Abstract: A Drosophila laminin A chain gene was characterized as a 14 kb genomic nucleotide sequence which encodes an open reading frame of 3712 amino acids in 15 exons. Overall, this A chain is similar to its vertebrate counterparts, especially in its N‐ and C‐terminal globular domains, but the sequence that forms the laminin A short arm is quite different and larger. Laminin messages appear in newly formed mesoderm and are later prominently expressed in hemocytes, which also synthesize basement membrane collagen IV. T… Show more

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Cited by 119 publications
(88 citation statements)
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References 61 publications
(34 reference statements)
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“…To identify ligands for presynaptic integrin signaling in NMJ growth regulation, we examined the localization of laminins at NMJs. The Drosophila α subunits LanA and Wing blister (Wb) showed similarity to mammalian α3/α5 and α1/α2, respectively (24,25). LanA signals were detected at NMJs and diminished in hypomorphic LanA 9-32/216 animals ( Fig.…”
Section: Resultsmentioning
confidence: 93%
“…To identify ligands for presynaptic integrin signaling in NMJ growth regulation, we examined the localization of laminins at NMJs. The Drosophila α subunits LanA and Wing blister (Wb) showed similarity to mammalian α3/α5 and α1/α2, respectively (24,25). LanA signals were detected at NMJs and diminished in hypomorphic LanA 9-32/216 animals ( Fig.…”
Section: Resultsmentioning
confidence: 93%
“…We find that the C. elegans laminin αA chain is typical with two exceptions: there are only four LG domains instead of the usual five and there are an additional two LE modules (10 instead of eight). In Drosophila, two α subunits and a β and γ subunit have been described (Chi and Hui, 1988;Chi and Hui, 1989;Chi et al, 1991;Garcia-Alonso et al, 1996;Haag et al, 1999;Henchcliffe et al, 1993;Kusche-Gullberg et al, 1992;Martin et al, 1999;Montell and Goodman, 1988;Montell and Goodman, 1989;Yarnitzky and Volk, 1995). One of the Drosophila α subunits is similar to the C. elegans αA subunit and the vertebrate α1 and α2 subunits, whereas the other is similar to the C. elegans αB subunit and to the vertebrate α3, and α5 subunits (Martin et al, 1999).…”
Section: Discussionmentioning
confidence: 99%
“…However, with the notable exception of the integrins, the functional roles of most of the Drosophila ECM/cell adhesion molecules have not been defined precisely for want of an informative mutant phenotype. For example, null alleles of the gene encoding the substrate adhesion molecule laminin A (Garrison et al 1991;Kusche-Gullberg 1992;Henchcliffe et al 1993) exhibit no obvious embryonic morphological abnormalities. However, an array of defective adult structures was reported (Henchcliffe et al 1993).…”
Section: I(1)myospheroid (Rays)mentioning
confidence: 99%