Laminin coated diamond electrodes for neural stimulation

Sikder, Kabir Uddin; Tong, Wei; Pingle, Hitesh; Kingshott, Peter; Needham, Karina; Shivdasani, Mohit N.; Fallon, James B; Seligman, P. M.; Ibbotson, M.; Prawer, S.; Garrett, David J.

doi:10.1016/j.msec.2020.111454

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…Particularly, the laminin also promoted enhanced cell attachment densities and neurite outgrowth, therefore reducing the inflammatory responses in vivo. [ 242 ] Chan et al. [ 243 ] modified a plasma protein (PP) on IrO x to achieve IrO x ‐PP neural electrode.…”

Section: Strategies For Improving Durability Of Neural Interfacesmentioning

confidence: 99%

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Zeng

Huang

2023

Adv Funct Materials

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The desirable implantable neural interfaces can accurately record bioelectrical signals from neurons and regulate neural activities with high spatial/time resolution, facilitating the understanding of neuronal functions and dynamics. However, the electrochemical performance (impedance, charge storage/injection capacity) is limited with the miniaturization and integration of neural electrodes. The “crosstalk” caused by the uneven distribution of elctric field leads to lower electrical stimulation/recording efficiency. The mismatch between stiff electrodes and soft tissues exacerbates the inflammatory responses, thus weakening the transmission of signals. Though remarkable breakthroughs have been made through the incorporation of optimizing electrode design and functionalized nanomaterials, the chronic stability, and long‐term activity in vivo of the neural electrodes still need further development. In this review, the neural interface challenges mainly on electrochemistry and biology are discussed, followed by summarizing typical electrode optimization technologies and exploring recent advances in the application of nanomaterials, based on traditional metallic materials, emerging 2D materials, conducting polymer hydrogels, etc., for enhancing neural interfaces. The strategies for improving the durability including enhanced adhesion and minimized inflammatory response, are also summarized. The promising directions are finally presented to provide enlightenment for high‐performance neural interfaces in future, which will promote profound progress in neuroscience research.

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Section: Strategies For Improving Durability Of Neural Interfacesmentioning

confidence: 99%

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Zeng

Huang

2023

Adv Funct Materials

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“…While the potential toxicity of carbon-based materials as biomedical implants, [241][242][243] including diamond, carbon nanotubes (CNTs), carbon nanofibers (CNFs), and various forms of graphene, are of concern, their tunable electrical properties and structural flexibility make them an attractive conductive material for interfacing with neural cells. [244] Carbon-based materials such as diamond, CNTs, CNFs, and graphene have conductivities of 1 × 10 −2 -1 × 10 −15 , [245] 1 × 10 3 -1 × 10 7 , [245] 1-5 × 10 4 , [246,247] and 2 × 10 3 -1 × 10 5 S cm −1 , [245] respectively (Table 1).…”

Section: Carbon-based Materialsmentioning

confidence: 99%

“…[ 248 ] Such diamond‐coated electrodes have been functionalized with cell adhesive macromolecules, such as laminin, to improve neuronal attachment. [ 200,249 ] Alternatively, CNTs, CNFs, and graphene are good electrical conductors and each is under extensive investigation for neural tissue interfacing. For an in‐depth review of carbon‐based material interactions with neural cells please refer to Rauti et al [ 245 ]…”

Section: Commonly Used Electronic Materialsmentioning

confidence: 99%

Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells

Bierman-Duquette

Safarians

Huang

et al. 2021

Adv Healthcare Materials

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Conductive biomaterials provide an important control for engineering neural tissues, where electrical stimulation can potentially direct neural stem/progenitor cell (NS/PC) maturation into functional neuronal networks. It is anticipated that stem cell-based therapies to repair damaged central nervous system (CNS) tissues and ex vivo, "tissue chip" models of the CNS and its pathologies will each benefit from the development of biocompatible, biodegradable, and conductive biomaterials. Here, technological advances in conductive biomaterials are reviewed over the past two decades that may facilitate the development of engineered tissues with integrated physiological and electrical functionalities. First, one briefly introduces NS/PCs of the CNS. Then, the significance of incorporating microenvironmental cues, to which NS/PCs are naturally programmed to respond, into biomaterial scaffolds is discussed with a focus on electrical cues. Next, practical design considerations for conductive biomaterials are discussed followed by a review of studies evaluating how conductive biomaterials can be engineered to control NS/PC behavior by mimicking specific functionalities in the CNS microenvironment. Finally, steps researchers can take to move NS/PC-interfacing, conductive materials closer to clinical translation are discussed.

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“…Several applications can be found for BNCD electrodes and microelectrodes, including treatment of polluted waters [ 3 , 4 ], electroactive implants [ 5 , 6 , 7 ], electroanalysis [ 8 ], drugs analysis [ 9 ], and electrophysiology [ 10 ]. In the field of life sciences, they have been applied most often for the amperometric electrochemical detection of secretory events (exocytosis) from neuroendocrine cells [ 11 , 12 , 13 , 14 , 15 ] and for measuring action potentials [ 16 , 17 , 18 ], both in vitro and in vivo [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Diamond Microelectrode Application in the Detection of Ca2+ Transport by AnnexinA5-Containing Nanostructured Liposomes

et al. 2022

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This report describes the innovative application of high sensitivity Boron-doped nanocrystalline diamond microelectrodes for tracking small changes in Ca2+ concentration due to binding to Annexin-A5 inserted into the lipid bilayer of liposomes (proteoliposomes), which could not be assessed using common Ca2+ selective electrodes. Dispensing proteoliposomes to an electrolyte containing 1 mM Ca2+ resulted in a potential jump that decreased with time, reaching the baseline level after ~300 s, suggesting that Ca2+ ions were incorporated into the vesicle compartment and were no longer detected by the microelectrode. This behavior was not observed when liposomes (vesicles without AnxA5) were dispensed in the presence of Ca2+. The ion transport appears Ca2+-selective, since dispensing proteoliposomes in the presence of Mg2+ did not result in potential drop. The experimental conditions were adjusted to ensure an excess of Ca2+, thus confirming that the potential reduction was not only due to the binding of Ca2+ to AnxA5 but to the transfer of ions to the lumen of the proteoliposomes. Ca2+ uptake stopped immediately after the addition of EDTA. Therefore, our data provide evidence of selective Ca2+ transport into the proteoliposomes and support the possible function of AnxA5 as a hydrophilic pore once incorporated into lipid membrane, mediating the mineralization initiation process occurring in matrix vesicles.

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Laminin coated diamond electrodes for neural stimulation

Cited by 14 publications

References 36 publications

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells

Ultrasensitive Diamond Microelectrode Application in the Detection of Ca2+ Transport by AnnexinA5-Containing Nanostructured Liposomes

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