Laminin-derived Ile-Lys-Val-ala-Val: a promising bioactive peptide in neural tissue engineering in traumatic brain injury

Negah, Sajad Sahab; Khooei, Alireza; Samini, Fariborz; Gorji, Ali

doi:10.1007/s00441-017-2717-6

Cited by 40 publications

(19 citation statements)

References 122 publications

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“…For OPCs, various integrin dimers with the β 1 subunit have been found to promote survival, regulate a switch from proliferation to differentiation and mediate myelination by mature oligodendrocytes . Several studies have found that inclusion of IKVAV peptides in hydrogel‐type biomaterials increased neuronal differentiation of transplanted NS/PCs after traumatic brain injury . Inclusion of IKVAV has also been reported to reduce astrogliosis after injury .…”

Section: Discussionmentioning

confidence: 99%

“…97,98 Several studies have found that inclusion of IKVAV peptides in hydrogel-type biomaterials increased neuronal differentiation of transplanted NS/PCs after traumatic brain injury. 99 Inclusion of IKVAV has also been reported to reduce astrogliosis after injury. 100,101 In vitro, IKVAV-bearing hydrogels are reported to promote differentiation of neurons while reducing differentiation of astrocytes.…”

Section: Discussionmentioning

confidence: 99%

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Peptide‐modified, hyaluronic acid‐based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering

Seidlits

Liang

Bierman

et al. 2019

J Biomedical Materials Res

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Neural stem/progenitor cell (NS/PC)‐based therapies have shown exciting potential for regeneration of the central nervous system (CNS) and NS/PC cultures represent an important resource for disease modeling and drug screening. However, significant challenges limiting clinical translation remain, such as generating large numbers of cells required for model cultures or transplantation, maintaining physiologically representative phenotypes ex vivo and directing NS/PC differentiation into specific fates. Here, we report that culture of human NS/PCs in 3D, hyaluronic acid (HA)‐rich biomaterial microenvironments increased differentiation toward oligodendrocytes and neurons over 2D cultures on laminin‐coated glass. Moreover, NS/PCs in 3D culture exhibited a significant reduction in differentiation into reactive astrocytes. Many NS/PC‐derived neurons in 3D, HA‐based hydrogels expressed synaptophysin, indicating synapse formation, and displayed electrophysiological characteristics of immature neurons. While inclusion of integrin‐binding, RGD peptides into hydrogels resulted in a modest increase in numbers of viable NS/PCs, no combination of laminin‐derived, adhesive peptides affected differentiation outcomes. Notably, 3D cultures of differentiating NS/PCs were maintained for at least 70 days in medium with minimal growth factor supplementation. In sum, results demonstrate the use of 3D, HA‐based biomaterials for long‐term expansion and differentiation of NS/PCs toward oligodendroglial and neuronal fates, while inhibiting astroglial fates. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 704–718, 2019.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Peptide‐modified, hyaluronic acid‐based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering

Seidlits

Liang

Bierman

et al. 2019

J Biomedical Materials Res

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“…They also participate in early embryonic development and organogenesis. Laminins and laminin-derived peptides are successfully used for enrichment of biomaterials [38,75,82,83].…”

Section: Lamininsmentioning

confidence: 99%

“…Another important integrin binding ligands come from laminins. Thus, IKVAV (Ile-Lys-Val-Ala-Val) and YIGSR (Tyr-Ile-Gly-Ser-Arg) are considered as the most promising pro-adhesive motifs [38,75,82,83].…”

Section: Peptidesmentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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“…The desirable properties of a scaffold for stem cell transplantation are biocompatibility, biodegradability, mimic the 3D biological microenvironment, incorporation of different ECM, pore size, stability, electrical conductivity, porosity, non-immunogenicity, interconnectivity, safety (low or non-toxic) and alignment[ 70 , 76 , 77 ]. Various fabrication techniques have been developed to produce different scaffolds, such as emulsion freeze-drying, electrospinning, thermally-induced phase separation, solvent casting/particular leaching, computer-aided design/computer-aided manufacturing, melt molding, rapid prototyping (3D printing, selective laser sintering, stereolithography, and fused deposition modeling), nanofiber self-assembly, and photolithography[ 78 , 79 ].…”

Section: Different Types Of Scaffold Formulationsmentioning

confidence: 99%

Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies

Granz

Gorji

2020

WJSC

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Dental stem cells (DSCs) are self-renewable cells that can be obtained easily from dental tissues, and are a desirable source of autologous stem cells. The use of DSCs for stem cell transplantation therapeutic approaches is attractive due to their simple isolation, high plasticity, immunomodulatory properties, and multipotential abilities. Using appropriate scaffolds loaded with favorable biomolecules, such as growth factors, and cytokines, can improve the proliferation, differentiation, migration, and functional capacity of DSCs and can optimize the cellular morphology to build tissue constructs for specific purposes. An enormous variety of scaffolds have been used for tissue engineering with DSCs. Of these, the scaffolds that particularly mimic tissue-specific micromilieu and loaded with biomolecules favorably regulate angiogenesis, cell-matrix interactions, degradation of extracellular matrix, organized matrix formation, and the mineralization abilities of DSCs in both in vitro and in vivo conditions. DSCs represent a promising cell source for tissue engineering, especially for tooth, bone, and neural tissue restoration. The purpose of the present review is to summarize the current developments in the major scaffolding approaches as crucial guidelines for tissue engineering using DSCs and compare their effects in tissue and organ regeneration.

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Laminin-derived Ile-Lys-Val-ala-Val: a promising bioactive peptide in neural tissue engineering in traumatic brain injury

Cited by 40 publications

References 122 publications

Peptide‐modified, hyaluronic acid‐based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering

Peptide‐modified, hyaluronic acid‐based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies

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