1995
DOI: 10.1002/jnr.490420417
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Laminin overrides the inhibitory effects of peripheral nervous system and central nervous system myelin‐derived inhibitors of neurite growth

Abstract: Axon growth inhibitory proteins associated with central nervous system (CNS) myelin are responsible in part for the absence of long distance axon regeneration in the adult mammalian CNS. We have recently reported that myelin-associated glycoprotein (MAG), which is also present in peripheral nerves, is a potent inhibitor of neurite growth. This was surprising given the robust regenerative capacity of peripheral nerves. We now provide evidence that myelin purified from peripheral nerve also has neurite growth in… Show more

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Cited by 100 publications
(68 citation statements)
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“…1A). These results are consistent with earlier studies showing that signaling events activated by laminin can abolish the inhibitory effect of CNS myelins (David et al, 1995), and a more recent study that laminin overrides the inhibitory effect of MAG (Laforest et al, 2005). In significant contrast, aggrecan, a component of CSPGs, significantly abolished NGF-induced axon assembly of naive neurons cultured in the presence of laminin (Fig.…”
Section: Resultssupporting
confidence: 93%
See 1 more Smart Citation
“…1A). These results are consistent with earlier studies showing that signaling events activated by laminin can abolish the inhibitory effect of CNS myelins (David et al, 1995), and a more recent study that laminin overrides the inhibitory effect of MAG (Laforest et al, 2005). In significant contrast, aggrecan, a component of CSPGs, significantly abolished NGF-induced axon assembly of naive neurons cultured in the presence of laminin (Fig.…”
Section: Resultssupporting
confidence: 93%
“…Since acute NGF treatment of DRG neurons was unable to overcome the inhibitory effect of MAG when neurons were cultured on poly-D-lysine (Cai et al, 1999), our result suggests that laminin acts to antagonize the effect of Nogo. Indeed, a previous observation has shown that laminin is able to overcome the inhibitory effect of CNS myelins (David et al, 1995). Moreover, a recent study has also demonstrated that laminin is able to override the inhibitory effect of MAG by regulation of Rac activity (Laforest et al, 2005).…”
Section: Discussionmentioning
confidence: 97%
“…Growth cones of severed axons grow in response to inhibitory and permissive signals in the nervous system, respectively [28]. Following injury, the spinal cord scar consists of a mixture of growth-promoting molecules such as laminin [10,39], cell adhesion molecules [57], and growth factors in combination with growth-inhibitory molecules. Unfortunately, inhibitory molecules dominate, resulting in a net inhibition of axon growth.…”
Section: Introductionmentioning
confidence: 99%
“…In retrospect, the lack of inhibitory activity previously reported for peripheral nerve myelin resulted from copurification of laminin from the basal lamina. Laminin can override the growth inhibitory activity of MAG (16). Moreover, despite its presence in peripheral nerve myelin, MAG does not block regeneration.…”
mentioning
confidence: 98%