Laminin regulates oligodendrocyte development and myelination

Kang, Min-Kyung; Yao, Yao

doi:10.1002/glia.24117

Cited by 27 publications

(17 citation statements)

References 197 publications

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“…Laminins are heterotrimers consisting of α, β and γ subunits (Fig. 2 ), of which 5 α, 4 β and 3 γ have been so far defined allowing the generation of up to 20 different laminin isoforms [ 71 ]. The current nomenclature dictates that laminins are named according to their subunit make-up, so for instance, laminin-111 is composed of the subunits α1, β1 and γ1.…”

Section: Laminins and Other Vascular Basement Membrane Extracellular ...mentioning

confidence: 99%

“…As members of the laminin family are composed of three subunits, α, β and γ, the impact of deletion of any one subunit depends largely on how widely that subunit is expressed amongst different tissues and cell types [ 60 – 62 , 70 , 71 ]. This is well illustrated by global deletion of the γ1 laminin subunit which shows an embryonic lethal phenotype due to total loss of the ability to develop basement membranes and thus blood vessels [ 6 ].…”

Section: Laminins and Other Vascular Basement Membrane Extracellular ...mentioning

confidence: 99%

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The impact of genetic manipulation of laminin and integrins at the blood–brain barrier

Halder

Sapkota

Milner

2022

Fluids Barriers CNS

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Blood vessels in the central nervous system (CNS) are unique in having high electrical resistance and low permeability, which creates a selective barrier protecting sensitive neural cells within the CNS from potentially harmful components in the blood. The molecular basis of this blood–brain barrier (BBB) is found at the level of endothelial adherens and tight junction protein complexes, extracellular matrix (ECM) components of the vascular basement membrane (BM), and the influence of adjacent pericytes and astrocyte endfeet. Current evidence supports the concept that instructive cues from the BBB ECM are not only important for the development and maturation of CNS blood vessels, but they are also essential for the maintenance of vascular stability and BBB integrity. In this review, we examine the contributions of one of the most abundant ECM proteins, laminin to BBB integrity, and summarize how genetic deletions of different laminin isoforms or their integrin receptors impact BBB development, maturation, and stability.

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Section: Laminins and Other Vascular Basement Membrane Extracellular ...mentioning

confidence: 99%

Section: Laminins and Other Vascular Basement Membrane Extracellular ...mentioning

confidence: 99%

The impact of genetic manipulation of laminin and integrins at the blood–brain barrier

Halder

Sapkota

Milner

2022

Fluids Barriers CNS

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“…The LG1-3 and LG4-5 modules bind to integrins and α-dystroglycan/sulfatide/heparan sulfate proteoglycans (HSPGs), respectively ( Suzuki et al, 2005 ). Laminins regulate survival, migration, proliferation, differentiation, and myelination of OL lineage cells through the receptors ( Kang and Yao, 2022 ). The gene mutations of laminin α2 chain in mice cause the defects in OPC survival and delayed myelination ( Relucio et al, 2012 ) and those in human are linked to the abnormality in the white matter ( Arreguin and Colognato, 2020 ), indicating that laminin is required for proper myelination in the CNS.…”

Section: The Functions Of Ecm Proteins In Ol Development and Patholog...mentioning

confidence: 99%

“…The gene mutations of laminin α2 chain in mice cause the defects in OPC survival and delayed myelination ( Relucio et al, 2012 ) and those in human are linked to the abnormality in the white matter ( Arreguin and Colognato, 2020 ), indicating that laminin is required for proper myelination in the CNS. Further, not only congenital defects in the laminin function but also the involvement of laminin activities in pathogenesis of stroke and MS are reported ( Kang and Yao, 2022 ).…”

Section: The Functions Of Ecm Proteins In Ol Development and Patholog...mentioning

confidence: 99%

The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins

Yamada

Iwase

Sasaki

et al. 2022

Front. Cell Dev. Biol.

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Oligodendrocytes are myelin-forming cells in the central nervous system (CNS). The development of oligodendrocytes is regulated by a large number of molecules, including extracellular matrix (ECM) proteins that are relatively less characterized. Here, we review the molecular functions of the major ECM proteins in oligodendrocyte development and pathology. Among the ECM proteins, laminins are positive regulators in oligodendrocyte survival, differentiation, and/or myelination in the CNS. Conversely, fibronectin, tenascin-C, hyaluronan, and chondroitin sulfate proteoglycans suppress the differentiation and myelination. Tenascin-R shows either positive or negative functions in these activities. In addition, the extracellular domain of the transmembrane protein teneurin-4, which possesses the sequence homology with tenascins, promotes the differentiation of oligodendrocytes. The activities of these ECM proteins are exerted through binding to the cellular receptors and co-receptors, such as integrins and growth factor receptors, which induces the signaling to form the elaborated and functional structure of myelin. Further, the ECM proteins dynamically change their structures and functions at the pathological conditions as multiple sclerosis. The ECM proteins are a critical player to serve as a component of the microenvironment for oligodendrocytes in their development and pathology.

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“…Although the SEZ is not anatomically separated by the adjacent tissue, it is a specialized microenvironment characterized by a specific 3-dimensional (3D) architecture of ependymal cells, NSCs and downstream progenitors, as well as blood vessels [ 13 , 14 ]. Also specialized is the SEZ’s composition of the extracellular matrix (ECM) [ 15 , 16 , 17 ], with one of its major components being laminin, a heterotrimeric protein, composed of α, β, and γ chains that form a cross-shape [ 18 ]. Notably, neural stem and progenitor cells produce their own ECM, including laminins, which regulate their survival and proliferation [ 16 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays

Anesti

Magkafa

Prantikou

et al. 2022

Cells

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Two main stem cell pools exist in the postnatal mammalian brain that, although they share some “stemness” properties, also exhibit significant differences. Multipotent neural stem cells survive within specialized microenvironments, called niches, and they are vulnerable to ageing. Oligodendroglial lineage-restricted progenitor cells are widely distributed in the brain parenchyma and are more resistant to the effects of ageing. Here, we create polymorphic neural stem cell cultures and allow cells to progress towards the neuronal and the oligodendroglial lineage. We show that the divergence of cell fate is accompanied by a divergence in the properties of progenitors, which reflects their adaptation to life in the niche or the parenchyma. Neurogenesis shows significant spatial restrictions and a dependence on laminin, a major niche component, while oligodendrogenesis shows none of these constraints. Furthermore, the blocking of integrin-β1 leads to opposing effects, reducing neurogenesis and enhancing oligodendrogenesis. Therefore, polymorphic neural stem cell assays can be used to investigate the divergence of postnatal brain stem cells and also to predict the in vivo effects of potential therapeutic molecules targeting stem and progenitor cells, as we do for the microneurotrophin BNN-20.

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Laminin regulates oligodendrocyte development and myelination

Cited by 27 publications

References 197 publications

The impact of genetic manipulation of laminin and integrins at the blood–brain barrier

The impact of genetic manipulation of laminin and integrins at the blood–brain barrier

The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins

Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays

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