2005
DOI: 10.1016/j.yexcr.2005.04.009
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Laminins 2 (α2β1γ1, Lm-211) and 8 (α4β1γ1, Lm-411) are synthesized and secreted by tooth pulp fibroblasts and differentially promote neurite outgrowth from trigeminal ganglion sensory neurons

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Cited by 24 publications
(22 citation statements)
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“…Cleavage of LN-5 by MMP-2 has been shown to expose a cryptic site that induces migration of epithelial cells (Giannelli et al, 1997), demonstrating that processing of laminins by specific proteases may contribute to processes requiring cell migration. Interestingly, although LN-1 (α1β1γ1) is one of the major laminins in neural tissues, other components of this family, including LN-2 (α2β1γ1) and LN-10 (α5β1γ1), are also expressed in neural tissues and have been associated with neurite outgrowth (Colognato and Yurchenco, 2000;Fried et al, 2005;Powell et al, 1998;Vuolteenaho et al, 1994), suggesting that cleavage of these proteins by plasmin could also contribute to neuritogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Cleavage of LN-5 by MMP-2 has been shown to expose a cryptic site that induces migration of epithelial cells (Giannelli et al, 1997), demonstrating that processing of laminins by specific proteases may contribute to processes requiring cell migration. Interestingly, although LN-1 (α1β1γ1) is one of the major laminins in neural tissues, other components of this family, including LN-2 (α2β1γ1) and LN-10 (α5β1γ1), are also expressed in neural tissues and have been associated with neurite outgrowth (Colognato and Yurchenco, 2000;Fried et al, 2005;Powell et al, 1998;Vuolteenaho et al, 1994), suggesting that cleavage of these proteins by plasmin could also contribute to neuritogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Later, a shift from repulsive to attractive factors apparently takes place, and nerve fibers then enter the tooth (Lillesaar and Fried 2004;Kettunen et al 2005). When nerve fibers have invaded the dental mesenchyme, an event that takes place during the first post-natal week in rodents, a complicated interplay of secreted and membrane-bound factors probably directs the nerve terminals to appropriate sites (Fried et al 2005). Hypothetically, HMGB1 might be involved in this process, since the present results strongly indicate that tooth-pulp-innervating trigeminal neurons express its receptor RAGE.…”
Section: Discussionmentioning
confidence: 99%
“…Extracts from bovine dentin or rat pulpal fibroblasts (for details of dentin and pulpal cell protein extraction, see, respectively, Petersson et al 2003;Fried et al 2005) were electroblotted onto a polyvinylidene fluoride (PVDF) membrane (Immobilon-P; Millipore, Bedford, Mass., USA.) following SDS-polyacrylamide gel electrophoresis (SDS-PAGE; Towbin et al 1979).…”
Section: Western Blot Analysismentioning
confidence: 99%
“…Expression of laminin α 1 (possibly forming laminin-111, α 1 β 1 γ 1) has been detected in trigeminal nerve bundles [52], indicating that Schwann cells in some locations express this subunit. Also, in peripheral nerves of laminin α 2 deficient mice, laminin α 1 can be detected [53, 54], but the functional effects of this compensatory upregulation are not yet clear.…”
Section: Ecm Molecules and Neuronal Regenerationmentioning
confidence: 99%