“…and cytosolic enzymes involved in Acetyl-CoA production (ACLY, ACSS2), carbohydrate (GPI, PYGB), lipid (FASN, OLAH), purine (ADSL, PNP) and folate (MTFHD1) metabolism (Supplementary figure 1B); (ii) Enhanced mucosal epithelium development: upregulation of serine-threonine kinase STK26 mediated apical membrane remodeling, 47 , RAB11b mediated microvilli formation and intestinal cell polarity 48 and ARHGDIB, CFL1, EPS8L2, FSCN1, PLS1, PIP, POTEJ, TWF2 that play roles in cell growth and development (Supplementary figure 1C); (iii) Proinflammatory response mitigation: upregulation of TPT1 mediated T and NK cell suppression 49 and USP14 stabilizing IDO1 immunosuppressive molecule,50 and downregulation of SNAP23 regulated cytokine release, 51 CD81 mediated Th2 polarization52 and MATN2/3 extracellular matrix proteins involved in proinflammatory responses53,54 (Supplementary figure1D); (iv) Lowered systemic bioavailability: downregulation of surface adhesion molecules ITGB1/4 and LAMB1 may reduce HMEV migration and translocation through integrin-laminin interaction[55][56][57] (Supplementary figure1E).…”