Lamotrigine add-on for drug-resistant partial epilepsy

Ramaratnam, Sridharan; Panebianco, Mariangela; Marson, Anthony G

doi:10.1002/14651858.cd001909.pub2

Cited by 28 publications

(4 citation statements)

References 43 publications

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“…RE is a chronic and debilitating disease of the nervous system with epileptic seizure caused by accidental discharge of cerebral neurons, which may lead to stigma in patients ( 19-21 ). Therefore, appropriate inhibition of neuronal excitability is the key in selection of AEDs in RE children ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy

Zhang¹,

Li²,

Zhang³

et al. 2020

Exp Ther Med

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Efficacy and safety of sodium valproate (SV) and lamotrigine (LTG) in treating refractory epilepsy (RE) in children and the predictive value of serum neuron-specific enolase (NSE) and central nervous system specific S100β protein (S100β) on efficacy assessment were explored. A total of 110 RE children admitted to Xuzhou Children's Hospital, Xuzhou Medical University were enrolled. Patients treated with SV alone served as the control group (n=51), and those treated with SV plus LTG as the study group (n=59). Serum NSE and S100β expression levels were measured by enzyme-linked immunosorbent assay (ELISA). The efficacy, seizure frequency, adverse reactions, concentration of serum brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF), and expression of serum NSE and S100β were observed and compared. The total effective rate in the study group was significantly higher than that in the control group, and the seizure frequency and incidence of adverse reactions were significantly lower than that in the control group. The study group showed remarkably higher BDNF and NGF than the control group after treatment. The expression of serum NSE and S100β in effectively treated children were significantly lower than that in ineffectively treated children. The area under the curve (AUC) of serum NSE and S100β were 0.828 and 0.814 respectively. SV combined with LTG is better and safer than SV alone in the treatment of RE in children. Serum NSE and S100β are of high value in predicting the efficacy. Patients and methods General data. A total of 110 RE children admitted to Xuzhou Children's Hospital, Xuzhou Medical University (Xuzhou, China) from February 2018 to March 2019 were enrolled. Patients treated with SV alone served as the control group, and those treated with SV plus LTG as the study group. There were

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy

Zhang¹,

Li²,

Zhang³

et al. 2020

Exp Ther Med

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“…Lamotrigine is an antiepileptic drug indicated as an adjunctive therapy in children above the ages of two specifically for primary generalized tonic-clonic seizures. It is also indicated for the treatment of bipolar disorder in patients (Ramaratnam, Panebianco, & Marson, 2016). Although the mechanism of action of this drug is unknown, in vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate).…”

Section: Discussionmentioning

confidence: 99%

The Application of Text Mining Algorithms In Summarizing Trends in Anti-Epileptic Drug Research

Singh¹,

Karkare²,

Baswan³

et al. 2018

IJSP

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Content summarization is an important area of research in traditional data mining. The volume of studies published on anti-epileptic drugs (AED) has increased exponentially over the last two decades, making it an important area for the application of text mining based summarization algorithms. In the current study, we use text analytics algorithms to mine and summarize 10,000 PubMed abstracts related to anti-epileptic drugs published within the last 10 years. A Text Frequency -Inverse Document Frequency based filtering was applied to identify drugs with highest frequency of mentions within these abstracts. The US Food and Drug database was scrapped and linked to the results to quantify the most frequently mentioned modes of action and elucidate the pharmaceutical entities marketing these drugs. A sentiment analysis model was created to score the abstracts for sentiment positivity or negativity. Finally, a modified Latent Dirichlet Allocation topic model was generated to extract key topics associated with the most frequently mentioned AEDs. We found the top five most common drugs that appeared from the analysis were Gabapentin, Levetiracetam, Topiramate, Lamotrigine and Acetazolamide. We further listed the key topics associated with these drugs and the overall positive or negative sentiment associated with them. Results of this study provide accurate and data intensive insights on the progress of anti-epileptic drug research.In this study, we analyze 10,000 PubMed abstracts related to AEDs with the end goal of content summarization and Due to the coupling between θ and φ in the integrand (above equation), the precise implication in mLDA is obstinate (Blei et al., 2003).The number of topics was selected according to the Rate of Perplexity Change (RPC) previously described by Zhao and colleagues (Zhao et al., 2015). This algorithm yielded two key topics on average which were further curated manually.

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“…For example, lamotrigine showed the same benefit on seizure in three reviews [25,80,82], or melatonin used to reduce sleep latency [44] showed no benefit both in adults and children.…”

Section: Discussionmentioning

confidence: 99%

Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Janiaud

Lajoinie

Cour-Andlauer

et al. 2015

Journal of Clinical Epidemiology

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Lamotrigine add-on for drug-resistant partial epilepsy

Cited by 28 publications

References 43 publications

Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy

Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy

The Application of Text Mining Algorithms In Summarizing Trends in Anti-Epileptic Drug Research

Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

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