Lamotrigine induced lymphadenopathy: Case report and literature review

Pomeroy, Stephanie J.; Ndikumana, Robyn; Cavanagh, Jonathan

doi:10.1016/j.ijporl.2017.04.047

Cited by 8 publications

(8 citation statements)

References 6 publications

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“…A PubMed literature review was performed, and only four cases with antiepileptic drug‐induced pure cervical lymphadenopathy were retrieved 4‐7 . The offending drugs and their clinical characteristics are listed in the Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…A PubMed literature review was performed, and only four cases with antiepileptic drug-induced pure cervical lymphadenopathy were retrieved. [4][5][6][7] The offending drugs and their clinical characteristics are listed in the Table 1. Three cases were associated with LTG exposure and one with PHT exposure, while our index case was relevant to CBZ and OXC.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of the HLA‐B*15:02 allele with pure cervical lymphadenopathy induced by carbamazepine and oxcarbazepine: A case report and literature review

Liu

Song²,

Liu

et al. 2020

Basic Clin Pharma Tox

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of the HLA‐B*15:02 allele with pure cervical lymphadenopathy induced by carbamazepine and oxcarbazepine: A case report and literature review

Liu

Song²,

Liu

et al. 2020

Basic Clin Pharma Tox

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“…In all cases, lymphadenopathy was not associated with systemic features and resolved after lamotrigine was ceased. One case remained on lamotrigine for several months without progression in their symptoms (Pomeroy et al, 2017). This suggests that these cases were secondary to a different process from DRESS, which is more acute and progresses to multi-organ involvement.…”

Section: Declaration Of Conflicting Interestsmentioning

confidence: 93%

Measuring drug concentrations in breast milk to improve therapeutic monitoring and patient adherence in bipolar disorder: A case report

Pastol

Marois

Guilhaumou³

et al. 2021

Aust N Z J Psychiatry

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“…The current observation of neural plasticity by DTT is considered to be a valuable demonstration of the neuroprotective effect of lamotrigine and of the importance of AMPA receptors. However, it is also important to note reports of the side effects of lamotrigine, including rash, dizziness, diplopia, and lymphadenopathy [17].…”

Section: Pharmacological Effect Of Lamotrigine (Association With the mentioning

confidence: 99%

Improved Visualization of the Anterior Thalamic Radiation in Bipolar Disorder by Diffusion Tensor Tractography

Niida¹,

Uechi²,

Niida³

et al. 2018

CRCM

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Diffusion tensor imaging (DTI) is a method for noninvasively measuring and imaging the diffusion of water molecules using MRI. Diffusion tensor tractography (DTT) can be used to presume macroscopic nerve fascicle distribution by determining, based on information obtained by DTI, whether the diffusion anisotropy vectors of adjacent voxels are continuous or not. We prepared a DTT map of the cerebral white matter nerve fascicles and investigated its usefulness for differentiation between Alzheimer's disease and bipolar disorder (BD), a major depressive disorder, based on the nerve fiber depiction, in addition to the fractional anisotropy and apparent diffusion coefficient values. We encountered two cases of BD in which the DTT image of the anterior thalamic radiation (ATR) improved following effective treatment with lamotrigine. Lamotrigine increases the synaptic strength due to its effect of promoting the traffic of the α-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor on the neuronal membrane. Downregulation of postsynaptic AMPA receptor expression can reportedly be observed during depressive episodes in BD. We consider that visualization of improvement of the ATR in response to treatment with lamotrigine (related to its pharmacological effect on the AMPA receptor) is valuable, as it suggests reversibility of the damage of the nerve fibers in this disease condition.

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Lamotrigine induced lymphadenopathy: Case report and literature review

Cited by 8 publications

References 6 publications

Association of the HLA‐B*15:02 allele with pure cervical lymphadenopathy induced by carbamazepine and oxcarbazepine: A case report and literature review

Association of the HLA‐B*15:02 allele with pure cervical lymphadenopathy induced by carbamazepine and oxcarbazepine: A case report and literature review

Measuring drug concentrations in breast milk to improve therapeutic monitoring and patient adherence in bipolar disorder: A case report

Improved Visualization of the Anterior Thalamic Radiation in Bipolar Disorder by Diffusion Tensor Tractography

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