LAMP1 is more sensitive than LAMP2 in predicting prognosis of esophageal squamous cell carcinoma

Abstract

Background Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers, especially in China. Its 5-year survival rate remains very low. Lysosomal associated membrane proteins (LAMPs), including LAMP1 and LAMP2, are major protein components of the lysosome, which also plays an important role in tumor evolution. Our previous studies have confirmed that LAMP1 and LAMP2 play an important role in the evolution and prognosis of ESCC. To further explore their roles in ESCC, we compared the roles of LAMP1 and LAMP2 in predicting the prognosis of ESCC. Methods Five hundred and seventy-nine ESCC patients were enrolled in this study. The clinical information, address and telephone number of patients were collected from the medical records. Results The 3-year survival rate was 51.91% (231/445), and 5-year survival rate was 34.58% (83/240). Kaplan-Meier survival curves indicated that the higher the expression level of LAMP1, the worse the prognosis of patients, compared with LAMP2 (P<0.05). Additionally, we used the receiver operating characteristic (ROC) curves to compare the sensitivity and specificity of LAMP1 and LAMP2 in predicting prognosis of ESCC. The area under the curve (AUC) of LAMP1 was significantly higher than that of LAMP2 (AUC LAMP1 =0.593, AUC LAMP2 =0.534, P<0.05), which indicated that the LAMP1 is a more sensitive marker than LAMP2. Conclusions LAMP1 is more sensitive than LAMP2 in predicting the prognosis of ESCC, which indicated that LAMP1 may play a more important role in the evolution and metastasis of ESCC.

A spatiotemporal comparative analysis on tumor immune microenvironment characteristics between neoadjuvant chemotherapy and preoperative immunotherapy for ESCC

“…The top three interactions in the former group were LAMP1-FAM3C, JAM3-JAM3 and FZD6-WNT5A, and in the latter group were EFNA1-EPHA2, EGFR-GRN, EFNA1-EPHA1. According to research reports, LAMP1, FAM3C and FZD6 all have the ability to predict the prognosis of ESCC, and WNT5A promotes ESCC metastasis by activating the HDAC7/SNAIL signaling pathway 24,32 . EEFNA1 encodes EPH protein and is involved in regulating developmental events, while EPHA2 can interact with EPHA1 to regulate the movement and proliferation of tumor cells 38 .…”