Satellite images cover large remote areas and are useful for detecting and monitoring water bodies. In Ecuador, since 1950, the lower Guayas River basin has undergone significant natural and anthropogenic changes that have impacted its dynamics and sustainability. This study aims to analyze through in situ data and geomatic techniques the change that the river has undergone in a decade by mapping the Suspended Sediment Concentration (SSC). Increasing levels of pollution in the river have raised concerns, prompting various approaches to measure and mitigate sedimentation to maintain the sustainable quality of the watershed. The spatiotemporal variations of SSC in the Guayas River revealed a remarkable variability, influenced by the operation of reservoirs, changes in land use, erosion, and sedimentation causing SSC in 2013 to range from 64.82 to 707.06 mg/l in the satellite image of 9/16/2013 and from 87.58 to 933.36 mg/l in the image of 7/26/2023. Understanding this distribution is crucial for the environmental protection and sustainability of aquatic ecosystems. This study used Landsat 8 data, an atmospheric pre-correction, and a remote sensing model. The results indicate a creasing trend of SSC in the stretches of the Guayas River between 2013 and 2023, which allows the understanding of the spatiotemporal dynamics of suspended sediment transport.