In the summer of 2022, Pakistan experienced a severe flood event that brought great destruction to the local people and ecosystem. However, there is no comprehensive study on the process, spread and causes of this flood. Therefore, we combined multiple satellite gravity data, meteorological data, hydrological data, and satellite remote sensing data to conduct a thorough investigation and study of this flood. The results show that a 20-year time series of the terrestrial water storage change based multiple gravity data has the high accuracy and reliability, which is used for detecting the flood. The flood propagated through meteorological system (three months), agricultural system (six months) and terrestrial ecosystems (five months), respectively, and the two southern provinces (Balochistan and Sindh) are the most affected by the flood, whose flood severity is 6.955 and 9.557, respectively. The center of the severe flood is located at the border region between the above two province. The severe flood is attributed primarily to the global extreme climate events (La Niña and negative Indian Ocean Dipole events) that altered the transport path of water vapor in the Indian Ocean, causing large amounts of water vapor to converge over Pakistan, resulting in heavy precipitation, and secondarily to the melting of extensive glacier in the mountainous of northern Pakistan as a result of the high temperature in March-May 2022. The above results contribute to the understanding of the mechanism of the impact of extreme climate events on the regional climate, and provide some references for the study of severe floods.