Landfill leachate ingestion induces protein oxidation and DNA–protein crosslinks in mouse viscera

Li, Hongyan; Han, Ming; Li, Hou; Li, Guangke; Sang, Nan

doi:10.1016/j.jhazmat.2009.09.015

Cited by 36 publications

(9 citation statements)

References 33 publications

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“…Most organs have the ability to sequester heavy metals following entry into the body [ 35 ]. This finding is in concert with several other findings [ [48] , [49] , [50] ]. Also, [ 51 ] in their study involving exposure of experimental animals to silica found significantly higher lung weight of the exposed animals when compared with the control.…”

Section: Discussionsupporting

confidence: 92%

Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats

2021

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Section: Discussionsupporting

confidence: 92%

Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats

2021

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“…Li et al [54] and Bakare et al [55] reported that the possible mechanism of municipal landfill and sludge leachates induced genotoxicity and toxicity in mice was by oxidative damage. Similarly, oxidative stress was implicated in incinerated bottom ash and municipal landfill leachates induced toxicity and genotoxicity in plant test systems [56][57][58].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Cytogenotoxicity and Oxidative Stress Induced by Electronic Waste Leachate and Contaminated Well Water

et al. 2013

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Environmental, plant and animal exposure to hazardous substances from electronic wastes (e-wastes) in Nigeria is increasing. In this study, the potential cytogenotoxicity of e-wastes leachate and contaminated well water samples obtained from Alaba International Electronic Market in Lagos, Nigeria, using induction of chromosome and root growth anomalies in Allium cepa, and micronucleus (MN) in peripheral erythrocytes of Clarias gariepinus, was evaluated. The possible cause of DNA damage via the assessments of liver malondialdehyde (MDA), catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD) as indicators of oxidative stress in mice was also investigated. There was significant (p < 0.05) inhibition of root growth and mitosis in A. cepa. Cytological aberrations such as spindle disturbance, C-mitosis and binucleated cells, and morphological alterations like tumor and twisting roots were also induced. There was concentration-dependent, significant (p < 0.05) induction of micronucleated erythrocytes and nuclear abnormalities such as blebbed nuclei and binucleated erythrocytes in C. gariepinus. A significant increase (p < 0.001) in CAT, GSH and MDA with concomitant decrease in SOD concentrations were observed in the treated mice. Pb, As, Cu, Cr, and Cd analyzed in the tested samples contributed significantly to these observations. This shows that the well water samples and leachate contained substances capable of inducing somatic OPEN ACCESSChallenges 2013, 4 170 mutation and oxidative stress in living cells; and this is of health importance in countries with risk of e-wastes exposure.

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“…Toxicity bioassays, in contrast to physicochemical analysis, integrate the biological effects of all compounds present and other factors, such as bioavailability and toxicants interactions (Žaltauskaitė and Čypaitė, 2008). Some studies show that leachate can cause deleterious effects on organisms at various trophic levels (Bakare and Osibanjo, 2000;Christensen et al, 2001;Bortolotto et al, 2009;Li et al, 2010). Among the various toxicity tests available, the seed germination and root elongation is a widely used, quick and accurate phytotoxicity test, showing sensitivity, simplicity, low cost and suitability for unstable chemicals or samples (Wang et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of phytotoxicity of municipal landfill leachate before and after biological treatment

2015

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In the present study, leachate toxicity of a municipal solid waste landfill located in the Sinos River Valley region (southern Brazil) was evaluated using plant bioassays. Leachate toxicity was assessed by analysis of seed germination and root elongation of lettuce (Lactuca sativa L.) and rocket plant (Eruca sativa Mill.) and root elongation of onions (Allium cepa L.). Bioassays were performed by exposing the seeds of L. sativa and E. sativa and the roots of A. cepa to raw leachate, treated leachate (biological treatment) and negative control (tap water). The levels of metals detected in both samples of leachate were low, and raw leachate showed high values for ammoniacal nitrogen and total Kjeldahl nitrogen. There is a reduction in the values of several physicochemical parameters, which demonstrates the efficiency of the treatment. Both L. sativa and A. cepa showed a phytotoxic response to landfill leachate, showing reduced root elongation. However, the responses of these two plant species were different. Root elongation was significantly lower in A. cepa exposed to treated leachate, when compared to negative control, but did not show any difference when compared to raw leachate. In L. sativa, seeds exposed to the raw leachate showed significant reduction in root elongation, when compared to treated leachate and negative control. Seed germination showed no difference across the treatments. The results of the study show that plant species respond differently and that municipal solid waste landfill leachate show phytotoxicity, even after biological treatment. Palavras-chave: bioensaios com plantas, poluição da água, tratamento de efluentes, efeitos tóxicos. Keywords

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Landfill leachate ingestion induces protein oxidation and DNA–protein crosslinks in mouse viscera

Cited by 36 publications

References 33 publications

Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats

Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats

In Vivo Cytogenotoxicity and Oxidative Stress Induced by Electronic Waste Leachate and Contaminated Well Water

Evaluation of phytotoxicity of municipal landfill leachate before and after biological treatment

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