2006
DOI: 10.1093/bja/ael069
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Landiolol, an ultra-short-acting beta 1-adrenoceptor antagonist, does not alter the electroencephalographic effect of isoflurane in swine model

Abstract: Landiolol does not alter the electroencephalographic effect of isoflurane.

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Cited by 14 publications
(9 citation statements)
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“…Of the many anesthetics, the administration of adrenergic ␤ 1 -receptor antagonist is known to be an effective approach in the treatment of tachycardia [1][2][3][4]. The use of this type of drugs offers significantly more rapid recovery by decreasing the anesthetic dose required to maintain an adequate depth of anesthesia and reduces postoperative analgesic requirement [5,6]. Landiolol hydrochloride, (−)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(S)-2-hydroxy-3-(2-morpholinocarbonylamino) ethylamino] propoxy] phenylpropionate monohydrochloride, is a newly developed ultra-short-acting ␤ 1 -receptor antagonist with a structural resemblance to esmolol [7].…”
Section: Introductionmentioning
confidence: 99%
“…Of the many anesthetics, the administration of adrenergic ␤ 1 -receptor antagonist is known to be an effective approach in the treatment of tachycardia [1][2][3][4]. The use of this type of drugs offers significantly more rapid recovery by decreasing the anesthetic dose required to maintain an adequate depth of anesthesia and reduces postoperative analgesic requirement [5,6]. Landiolol hydrochloride, (−)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(S)-2-hydroxy-3-(2-morpholinocarbonylamino) ethylamino] propoxy] phenylpropionate monohydrochloride, is a newly developed ultra-short-acting ␤ 1 -receptor antagonist with a structural resemblance to esmolol [7].…”
Section: Introductionmentioning
confidence: 99%
“…We used landiolol, an ultra‐short‐acting and highly β1‐selective β‐blocker (β1/β2 potency ratio of 255, compared with 33 for esmolol and 0.68 for propranolol) because titration of the drug effect is possible due to the short half‐life of 4 min. The landiolol doses were determined based on our previous swine studies . After completion of three apnea experiments, 600 ml of blood (approximately 33% of the estimated total blood volume) was removed for 20 min via the arterial catheter and then the same volume of hydroxyethylstarch was infused for 20 min via the central venous catheter (isovolemic hemodilution).…”
Section: Methodsmentioning
confidence: 99%
“…Thus, landiolol is suitable for stabilizing hemodynamics during the perioperative period. There have, however, been a few studies on the anesthetic-sparing effect of landiolol during anesthesia [24][25][26][27]. Kurita et al [26], using a swine model, examined the effects of landiolol on the MAC of isoflurane required to prevent movement in response to a noxious stimulus in 50% of the experimental animals.…”
Section: Reduction Of Anesthetic Requirementsmentioning
confidence: 99%