Landiolol, an Ultra-Short-Acting β&lt;sub&gt;1&lt;/sub&gt;-Blocker, More Effectively Terminates Atrial Fibrillation Than Diltiazem After Open Heart Surgery

Sakamoto, Atsuhiro; Kitakaze, Masafumi; Takamoto, Shinichi; Namiki, Akiyoshi; Kasanuki, Hiroshi; Hosoda, Saichi

doi:10.1253/circj.cj-11-1332

Cited by 66 publications

(59 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prophylactic administration of a β-blocker is already recommended. 37 Sezai et al reported that the perioperative infusion of landiolol before weaning from cardiopulmonary bypass and the initiation of oral bisoprolol on POD1 significantly lowered the incidence of POAF. 38 Most of the information about the effect of β-blockers on POAF has been obtained from patients undergoing CABG.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Can Predict Postoperative Atrial Fibrillation in Patients Undergoing Aortic Valve Replacement for Aortic Valve Stenosis

Takahashi

Fujiwara

Watadani

et al. 2014

Circ J

View full text Add to dashboard Cite

Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp and postoperative complications and requirements, have been evaluated as predictors of POAF; however, most of these predictors were not consistent among studies and only advanced age was a consistent predictor. 6 Recently, echocardiographic assessments have achieved much better prediction of POAF by measuring the left atrium-related values including the left atrial volume index (LAVI), LA strain and total atrial conduction time (TACT). Although there are several measurements of TACT, the time interval from the P-wave onset on the electrocardiogram (ECG) to the peak of the A' lateral wave on TDI (PA-TDI duration) provides a reliable estimation of TACT, and the PA-TDI duration has been shown to be significantly related to new-onset AF. 7,8 Our previous study revealed that the PA-TDI duration was predictive of AF in patients undergoing off-pump coronary artery bypass grafting (CABG). 9 trial fibrillation (AF) is a common complication after cardiac surgery, occurring in 10-65% of the patients. 1 Several studies have found adverse outcomes associated with postoperative AF (POAF), including increased risk of hospital stay, higher risk of stroke, permanent pacemaker implantation, and increased in-hospital and long-term mortality rates. 2 The incidence of POAF is higher with valvular surgery. 3 Obviously, in aortic valve (AV) surgery, the incidence of AF is related to these postoperative complications. 4 Moreover, Filardo et al reported that new-onset POAF was significantly associated with increased long-term risk of mortality in patients undergoing AV replacement (AVR) surgery. 5 These results indicate that POAF should be prevented and controlled postoperatively.In the past 2 decades, many clinical variables, including preoperative characteristics, comorbidities, intraoperative findings A

show abstract

Section: Discussionmentioning

confidence: 99%

Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Can Predict Postoperative Atrial Fibrillation in Patients Undergoing Aortic Valve Replacement for Aortic Valve Stenosis

Takahashi

Fujiwara

Watadani

et al. 2014

Circ J

View full text Add to dashboard Cite

show abstract

“…Sakamoto et al did not directly compare the 2 drugs, but they emphasized the few side effects with landiolol, noting that studies reporting the side effects of esmolol were not uncommon. 7 Although no direct comparison was undertaken in that study, hypotension <90 mmHg occurred in 4 cases among 35 subjects (11.4%) with landiolol 7 compared with 7 cases among 15 (46.7%) for esmolol. 4 Ikeshita et al 10 used whole isolated rabbit heart preparations to compared the inhibitory action of landiolol and esmolol against isoproterenol-induced tachycardia.…”

Section: Article P 1097mentioning

confidence: 83%

Intravenous Infusion of Ultra-Short-Acting β-Blocker for Postoperative Atrial Fibrillation Is the One of Choice

Amaki

2012

Circ J

View full text Add to dashboard Cite

“…This indicates that stress due to intubation and/or surgical procedures was lower in Group L. The finding that the heart rate was significantly lower in Group L even after landiolol infusion was ceased suggests that early introduction of this drug alleviated stress on the heart. This study employed landiolol infusion at 5 µg/kg/min, but reports on cardiovascular surgery indicate that it exerts a significant effect when infused at only 2 µg/kg/min [9] [13]. As a significant reduction in cardiac output during landiolol infusion has been reported in patients with a low cardiac output (ejection fraction < 50%) [14], patients with an ASA-PS score of 4 or higher were excluded from the present study.…”

Section: Discussionmentioning

confidence: 99%

Safety of Landiolol Infusion in Patients Undergoing Lung Resection

Ito¹,

Nozaki²,

Sakamoto³

et al. 2014

OJAnes

View full text Add to dashboard Cite

The efficacy of landiolol hydrochloride, an ultrashort-acting β-blocker with high β1 selectivity, has been confirmed in patients undergoing cardiac surgery in Japan, but there have been few reports about its use for patients having lung resection. We investigated the safety of continuous infusion of landiolol in patients undergoing lung resection. Between May 2008 and May 2011, 200 patients scheduled for lung resection were enrolled. Patients who underwent surgery before the introduction of landiolol in February 2010 were studied retrospectively (Group C) and were compared with those who received landiolol along with surgery (Group L). During the 48-hour study period, the incidence of arrhythmias, changes in heart rate and blood pressure, and occurrence of adverse reactions were examined. The white blood cell count and C-reactive protein level were measured before and after surgery to assess the anti-inflammatory effect. The heart rate was significantly lower in Group L throughout the study period. No patient in Group L developed hypotension requiring discontinuation of landiolol therapy, and no respiratory symptoms (including asthma or hypoxemia) were observed. White blood cell and C-reactive protein were significantly increased after surgery in both groups, and there were no between-group differences. Arrhythmic events occurred in 1.1% (1/99) and 9.2% (7/76) of Group L and Group C, respectively. One patient in Group C developed ventricular tachycardia. Landiolol can be administered safely during the perioperative period in patients undergoing lung resection.

show abstract

Landiolol, an Ultra-Short-Acting β<sub>1</sub>-Blocker, More Effectively Terminates Atrial Fibrillation Than Diltiazem After Open Heart Surgery

Cited by 66 publications

References 17 publications

Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Can Predict Postoperative Atrial Fibrillation in Patients Undergoing Aortic Valve Replacement for Aortic Valve Stenosis

Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Can Predict Postoperative Atrial Fibrillation in Patients Undergoing Aortic Valve Replacement for Aortic Valve Stenosis

Intravenous Infusion of Ultra-Short-Acting β-Blocker for Postoperative Atrial Fibrillation Is the One of Choice

Safety of Landiolol Infusion in Patients Undergoing Lung Resection

Contact Info

Product

Resources

About