Landscape of human organoids: Ideal model in clinics and research

Han, Xinxin; Cai, Chunhui; Deng, Wei; Shi, Yanghua; Li, Lanyang; Wang, Chen; Zhang, Jian; Rong, Mingjie; Liu, Jiping; Fang, Bangjiang; He, Hua; Liu, Xiling; Deng, Chuxia; He, Xiao; Cao, Xin

doi:10.1016/j.xinn.2024.100620

The Innovation

2024

DOI: 10.1016/j.xinn.2024.100620

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Landscape of human organoids: Ideal model in clinics and research

Xinxin Han,

Chunhui Cai,

Wei Deng

et al.

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2024

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Cited by 11 publications

(2 citation statements)

References 212 publications

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“…Organoids also advance understanding of developmental mechanisms, therapeutic target identification, and organ transplantation research [4] . Notably, brain organoids have shown potential in artificial intelligence applications [5][6][7][8] , such as speech recognition and nonlinear equation prediction. As research progresses, organoids are set to play a key role in personalized medicine and therapeutic interventions, enhancing our understanding of health and disease [9] .…”

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confidence: 99%

“…Limited understanding of tumor occurrence and organ development also impacts the maturity of organoids. To overcome these challenges, researchers are using interdisciplinary approaches and techniques like vascular system cultivation and organ-on-chip optimization to advance organoid research and its potential applications in disease modeling, drug discovery, and regenerative medicine [8] .…”

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Unveiling Cell Organoid: A vanguard in organoid research

Lou,

Wang,

Leng

et al. 2024

Cell Organoid

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confidence: 99%

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confidence: 99%

Unveiling Cell Organoid: A vanguard in organoid research

Lou,

Wang,

Leng

et al. 2024

Cell Organoid

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Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering

Hu,

Zhu,

Cui

et al. 2024

Adv Healthcare Materials

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Organoids, with their capacity to mimic the structures and functions of human organs, have gained significant attention for simulating human pathophysiology and have been extensively investigated in the recent past. Additionally, 3D bioprinting, as an emerging bio‐additive manufacturing technology, offers the potential for constructing heterogeneous cellular microenvironments, thereby promoting advancements in organoid research. In this review, the latest developments in 3D bioprinting technologies aimed at enhancing organoid engineering are introduced. The commonly used bioprinting methods and materials for organoids, with a particular emphasis on the potential advantages of combining 3D bioprinting with organoids are summarized. These advantages include achieving high cell concentrations to form large cellular aggregates, precise deposition of building blocks to create organoids with complex structures and functions, and automation and high throughput to ensure reproducibility and standardization in organoid culture. Furthermore, this review provides an overview of relevant studies from recent years and discusses the current limitations and prospects for future development.

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Unveiling the functional roles of patient‐derived tumour organoids in assessing the tumour microenvironment and immunotherapy

Chen,

Xu,

Xuan

et al. 2024

Clinical & Translational Med

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Recent studies have established the pivotal roles of patient‐derived tumour organoids (PDTOs), innovative three‐dimensional (3D) culture systems, in various biological and medical applications. PDTOs, as promising tools, have been established and extensively used for drug screening, prediction of immune response and assessment of immunotherapeutic effectiveness in various cancer types, including glioma, ovarian cancer and so on. The overarching goal is to facilitate the translation of new therapeutic modalities to guide personalised immunotherapy. Notably, there has been a recent surge of interest in the co‐culture of PDTOs with immune cells to investigate the dynamic interactions between tumour cells and immune microenvironment. A comprehensive and in‐depth investigation is necessary to enhance our understanding of PDTOs as promising testing platforms for cancer immunotherapy. This review mainly focuses on the latest updates on the applications and challenges of PDTO‐based methods in anti‐cancer immune responses. We strive to provide a comprehensive understanding of the potential and prospects of PDTO‐based technologies as next‐generation strategies for advancing immunotherapy approaches.

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Landscape of human organoids: Ideal model in clinics and research

Cited by 11 publications

References 212 publications

Unveiling Cell Organoid: A vanguard in organoid research

Unveiling Cell Organoid: A vanguard in organoid research

Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering

Unveiling the functional roles of patient‐derived tumour organoids in assessing the tumour microenvironment and immunotherapy

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