“…Importantly, CTLA4 and PAK2 mRNA levels were higher in tumor-infiltrating Tregs than in Tregs purified from the surrounding, nontumoral tissues or from the blood, as well as in Teff cells purified from the surrounding tissue, peripheral blood, or even from tumor-infiltrating Teff cell subsets (60). Similar observations were made for PAK2 in breast carcinoma and hepatocellular carcinoma clinical samples (61,62). These data suggest that, in clinical situations, the CTLA4/PKCη/GIT2/PAK2/αPIX pathway plays an important and selective role in the function of intratumoral Tregs.…”