Langerhans cell histiocytosis is a proliferative histiocytic disorder of unknown cause originating from dendritic cells. Its diagnosis requires a high index of suspicion, tissue sampling, and special staining. The authors report a case of Langerhans’ cell histiocytosis in a 2-year-old girl, presenting as a scalp abscess and diffuse dermatitis. Further evaluation revealed osteolytic changes of the cranium with biopsy showing malignant cells. Wide excision of the scalp mass was done and reconstructed with a scalp flap. She was managed postoperatively with systemic chemotherapy and is presently without any symptoms. Due to the diverse manifestations and the possibility of multisystem involvement, a thorough evaluation of a diagnosed patient is necessary for appropriate treatment. Key words: Langerhans cell histiocytosis, scalp