Langerhans cell histiocytosis in the adult clavicle: A case report

Abstract

Highlights Langerhans` Cell Histiocytosis is a rare disease involving proliferation of Langerhans-type cells, which shares immunophenotypic and ultrastructural similarities. LCH occurs dominantly in pediatric ages and involve cranium, pelvis, vertebrae, ribs, tubular bones and so forth. It is diagnosed by the means of histologic, immunochemical analysis. We encountered a very rare case of solitary LCH in an adult’s clavicle. We concluded LCH must be suspected as a diagnosis and ruled out when encountering primary tumorous lesion.

Diagnosis and treatment of adult Langerhans cell histiocytosis in the rib: a case report and literature review

“…LCH in the rib can be treated by surgery, radiotherapy, and typical application of glucocorticoids, and the 5-year local control rate can reach over 95% ( 23 ). However, given the rarity of the condition and the relatively good prognosis, treatment has not been standardized ( 24 ). Different approaches such as observation only, surgical resection, and chemotherapy have been implemented in our review, and the results show VATS can achieve the same outcome as traditional open thoracic surgery with less pain.…”