Langerhans cell histiocytosis of bone: MR imaging

George, Joseph C.; Buckwalter, Kenneth A.; Cohen, Mervyn D.; Edwards, Mary K.; Smith, Richard R.

doi:10.1007/bf02017655

Cited by 24 publications

(3 citation statements)

References 16 publications

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“…On fluid sensitive sequences Ewing sarcoma typically shows variable signal intensity, with possible hypointense appearance related to muscles as a consequence of high tumour cellularity, with pronounced contrast-enhanced MRI signal intensity. In our case we observed a notable contrast-enhancement, but with a dominant homogenous contrast-enhanced appearance of the tumour lesion [21, 22].…”

Section: Discussionmentioning

confidence: 89%

Atypical localization of intraosseous angioleiomyoma in the rib of a pediatric patient: a case report

et al. 2018

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BackgroundThis is the first reported case of a primary intraosseous angioleiomyoma and the second case of a primary leiomyoma of the rib, irrespective of age. Angioleiomyomas mostly occur in patients of advanced age, in any part of the body, particularly the lower extremities and present as painful, slow-growing nodules in the dermis, subcutaneous fat or deep fascia. Other localizations, especially bone, are considered extremely rare, as well as their occurrence in paediatric patients.Case presentationA 10-year-old girl was admitted to the orthopaedic surgery department for further assessment of a pain localized in the posterior part of the right hemithorax. After magnetic resonance imaging (MRI) and surgical biopsy, intraosseus angioleiomyoma of the fourth rib was diagnosed by histopathology examination. Atypical costal localization of this type of a benign tumour presents diagnostic difficulty, especially in children. The differential diagnoses included cartilaginous tumours, Ewing sarcoma, fibrous dysplasia, Langerhans cell histiocytosis, intraosseous haemangioma and metastatic tumours. We report a detailed diagnostic procedure including MRI, selective angiography and histopathologic examination.ConclusionDiagnosis of intraosseous angioleiomyoma is difficult due to the extreme rarity of this tumour and absence of pathognomonic radiological signs. Although very rarely identified in bones and young age group, radiographers and reporting doctors should be aware of this possible angioleiomyoma presentation and supported by the provided detailed diagnostic information.

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Section: Discussionmentioning

confidence: 89%

Atypical localization of intraosseous angioleiomyoma in the rib of a pediatric patient: a case report

et al. 2018

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“…Early disease is characterized by diffuse bone infiltration, which is an ill-defined process; extensive bone edema; periosteal reaction; and cortical destruction. Thus, the radiologic appearance is not specific, and early LCH may be difficult to differentiate from other bone conditions, such as Ewing sarcoma and osteosarcoma (10). Transition to the late stage of LCH is characterized by a predominance of the benign aspect of the lesion, with resolution of reactive edema and a less pronounced periosteal reaction.…”

Section: Discussionmentioning

confidence: 98%

Case 147: Langerhans Cell Histiocytosis of the Femur

Diederichs

Hauptmann²,

Schröder³

et al. 2009

Radiology

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“…The most common MR appearance of skeletal LCH was a focal lesion, surrounded by an extensive, ill-defined bone marrow and soft tissue reaction with low SI on T1 WIs and high SI on T2 WIs, considered to represent bone marrow and soft tissue edema. Those, especially during the early stages, are nonspecific, and may simulate an aggressive lesion such as osteomyelitis or Ewing sarcoma, or other benign bone tumors such as osteoid osteoma or chondroblastoma [16,17].…”

Section: Discussionmentioning

confidence: 99%

MRI and Histopathologic Classification of Langerhans Cell Histiocytosis

Moon¹,

Lee²,

Lee³

et al. 2009

CMIR

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Objective: The purpose of the study was to determine the stage of magnetic resonance images (MRI) of Langerhans cell histiocytosis (LCH). Materials and Methods:The MR images of 16 patients with a histopathologically proven diagnosis of LCH by curettage biopsy were analyzed retrospectively. There were 9 female and 7 male patients, age range 1-36 years, mean age 8.7 years. Lesions were located in the humerus (n=5), the femur (n=4), the pelvic ilium (n=3), the tibia (n=2), the scapula (n=1), and the metacarpal (n=1). We classified 'type A' as full hypercellularity lesion, 'type B' as peripheral hypercellularity and central fibrosis, and 'type C' as reduced cellularity on MRI of LCH. Histopathologic evolution of LCH comprised four different phases.Results: Four of 16 patients, who were reconfirmed to the first incipient phase of LCH histopathologically, revealed as one 'type A', two 'type A and B', and one 'type B'. Eight patients with the second phase revealed seven 'type B' and one 'type B and C' on the MRI. One patient with the third phase revealed 'type B'. Three patients with the last phase revealed all 'type C'. The MRI findings are well correlated with the histopathologic findings of LCH. Conclusion:The MRI classification could be useful for evaluating disease progression and therapeutic response of LCH.

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Langerhans cell histiocytosis of bone: MR imaging

Cited by 24 publications

References 16 publications

Atypical localization of intraosseous angioleiomyoma in the rib of a pediatric patient: a case report

Atypical localization of intraosseous angioleiomyoma in the rib of a pediatric patient: a case report

Case 147: Langerhans Cell Histiocytosis of the Femur

MRI and Histopathologic Classification of Langerhans Cell Histiocytosis

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