Langerhans cell histiocytosis of the cervical spine in an adult: a case report

Sayhan, Salih; Altinel, Deniz; Erguden, Cenk; Kızmazoğlu, Ceren; Güray, Merih; Acar, Ümit

doi:10.5137/1019-5149.jtn.1625-08.2

Cited by 9 publications

(15 citation statements)

References 15 publications

(31 reference statements)

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“…Arthrodesis was achieved in patients after immobilization by Minerva cast for 90 days. To handle lesions with greater extent of vertebral destruction, anterior corpectomy would be performed followed by mesh cage and plate instrumentation to obtain fusion in both pediatric and adult patients [7, 19]. The nuance between this surgery performed in different age group is that the longest possible mesh cage is recommended in children considering spine growth and restoration of the cervical lordosis curve.…”

Section: Discussionmentioning

confidence: 99%

The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability

Zhong

Meng

et al. 2016

World J Surg Onc

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BackgroundVarious therapeutic approaches have been proposed for the treatment of pediatric patients with eosinophilic granuloma (EG) of the cervical spine. Our aim was to discuss and present our experience with the individualized surgical intervention of pediatric cervical EG complicated with neurologic deficits and/or spinal instability.MethodsWe retrospectively analyzed the clinical data of 19 children who were diagnosed with cervical EG comor spinal/or spinal instability (evaluated by the Spinal Instability Neoplastic Score, SINS ≥ 7) and treated surgically in our institution.ResultsLesions involved C1–2 in 7 patients and C3–7 in 12 patients. Anterior tumor resection combined with posterior pedicle screw fixation, anterior approach of excision and instrumentation, and posterior tumor resection combined with pedicle screws instrumentation were selected according to the different locations of tumors. Frankel scale and Oucher scale improved significantly after surgery. There was no morphologic alteration of the neck at follow-up.ConclusionsSurgery can significantly improve the neurologic status and symptoms. Surgical decision-making must be individually tailored to minimize the influence of surgery on spine growth.

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Section: Discussionmentioning

confidence: 99%

The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability

Zhong

Meng

et al. 2016

World J Surg Onc

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“…[78] In the spine it usually presents with local pain and stiffness only. [2] Neurological symptoms are extremely rare and are usually limited to mild paresthesias or radicular pain. [9] In our case the patient had severe neurological deficits in the form of paraplegia and bowel/bladder symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…[49] Posterior arch involvement is very uncommon. [24] The level of spinal involvement varies at different ages. While in children, the thoracic spine (54%) is commoner, in adults, 47% of reported cases involve the cervical spine, 33% the thoracic spine, and 20% the lumbar spine.…”

Section: Discussionmentioning

confidence: 99%

“…[1] The designation of LCH has replaced the previous nomenclature of the group of diseases termed histiocytosis X, which included eosinophilic granuloma (EG), Letterer-Siwe Syndrome and Hand-Schuller-Christian disease. [2] The incidence of spinal involvement in this disease varies from 6.5 to 25% of cases with LCH of the skeleton. Eighty percent of cases occur in children younger than 10 years of age.…”

Section: Introductionmentioning

confidence: 99%

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Langerhans′ cell histiocytosis involving posterior elements of the dorsal spine: An unusual cause of extradural spinal mass in an adult

Tyagi

Balasubramaniam

Savant

2011

J Craniovert Jun Spine

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Langerhans cell histiocytosis (LCH) is a clonal proliferation of Langerhans cells occurring as an isolated lesion or as part of a systemic proliferation. It is commoner in children younger than 10 years of age with sparing of the posterior elements in more than 95% of cases. We describe a case of LCH in an adult female presenting with paraplegia. MRI revealed a well-defined extradural contrast enhancing mass at D2-D4 vertebral level involving the posterior elements of spine. D2-5 laminectomy with excision of lesion was performed which lead to marked improvement of patients neurological status. Histopathology was suggestive of eosinophilic granuloma. We describe the case, discuss its uniqueness and review the literature on this rare tumor presentation.

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“…The most common site of EG is the skull, vertebra occupied only 7%15). In particular, the incidence of primary cervical spine is only 0.02%6).…”

Section: Introductionmentioning

confidence: 99%

Primary Eosinophilic Granuloma of Adult Cervical Spine Presenting as a Radiculomyelopathy

Bang

Kim

Cho

et al. 2013

J Korean Neurosurg Soc

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We report a case of 29-year-old man diagnosed as a primary eosinophilic granuloma (EG) lesion of the seventh cervical vertebra. He had paresthesia on both arms, and grasping weakness for 10 days. Cervical magnetic resonance image (MRI) showed an enhancing mass with ventral epidural bulging and cord compression on the seventh cervical vertebra. Additionally, we performed spine series MRI, bone scan and positive emission tomography for confirmation of other bone lesions. These studies showed no other pathological lesions. He underwent anterior cervical corpectomy of the seventh cervical vertebra and plate fixation with iliac bone graft. After surgical management, neurological symptoms were much improved. Histopathologic evaluation confirmed the diagnosis of EG. There was no evidence of tumor recurrence at 12 months postoperative cervical MRI follow-up. We reported symptomatic primary EG of cervical spine successfully treated with surgical resection.

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Langerhans cell histiocytosis of the cervical spine in an adult: a case report

Cited by 9 publications

References 15 publications

The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability

The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability

Langerhans′ cell histiocytosis involving posterior elements of the dorsal spine: An unusual cause of extradural spinal mass in an adult

Primary Eosinophilic Granuloma of Adult Cervical Spine Presenting as a Radiculomyelopathy

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