Langerhans cell histiocytosis presenting as a lumbosacral intradural-extramedullary mass

Abstract

The subject of this paper is a 2-year-old child with progressive paraparesis. MRI showed a large lumbosacral intradural-extramedullary mass and the histological diagnosis was Langerhans cell histiocytosis. The histopathological and neuroradiological findings are discussed.

SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low and middle income settings

“…Without the minimum availability of CT scanning as well as a surgeon (and facilities) capable of resection of medulloblastoma, pathology services able to make the diagnosis, and the ability to deliver craniospinal radiotherapy, curative treatment of children with medulloblastoma is not possible (Table ). Imaging characteristics of medulloblastoma have been extensively reported . On CT or MRI imaging, the tumour is predominantly solid, classically arising from the vermis, less commonly from the cerebellar hemisphere.…”

Isolated langerhans cell histiocytosis masquerading as intradural extramedullary meningioma: Review on histiocytic disorders of spine

“…A similar case reported at intradural location, but at lumbar level, was similarly misdiagnosed as meningioma before a surprising histopathology diagnosis was made. [2] In that case, Birbeck granules was also demonstrated in electron microscopy. We did not used electron microscopy because IHC is equally sensitive and specific.…”

Intradural dirofilariasis mimicking a Langerhans cell histiocytosis tumor

“…The most frequent locations are bone, skin, lung, bone marrow, liver, or brain (hypothalamic‐pituitary area and more rarely the cerebellum). Exceptional cases of isolated intradural location have been reported 1, 2. Histological examination of the tumor shows a mixture of histiocyte cells with convoluted nuclear grooves and indentations, multinucleated giant cells, and a polymorphous inflammatory infiltrate of eosinophils, neutrophils, and lymphocytes.…”