Langerhans cell histiocytosis: unusual skeletal manifestations observed in thirty-four cases

Hindman, Bernard W.; Thomas, Richard; Young, Lionel W.; Yu, Leisure

doi:10.1007/s002560050361

Cited by 52 publications

(26 citation statements)

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“…Additionally, LCH can have some unusual radiographic features. 6 In this study, observation was a safe strategy and enabled 7 of 8 children to avoid an operation when their lesion resolved completely or almost completely without intervention.…”

Section: Discussionmentioning

confidence: 99%

Nonoperative management of solitary eosinophilic granulomas of the calvaria

Angulo

Nair

Lee

et al. 2013

PED

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Object Solitary eosinophilic granuloma (EG) of the calvaria is most commonly treated with surgical excision. The authors hypothesize that many solitary EGs will resolve without intervention, and observation may be a reasonable option. This study was undertaken to investigate that hypothesis. Methods The authors reviewed their institutional records and identified 14 cases of solitary calvarial EG. In 6 cases the patients underwent resection based on family and/or neurosurgeon preferences. A strategy of nonoperative management (purposeful observation) was chosen for the other 8 cases. The authors report the clinical course and imaging results in these 8 cases. Results One of the 8 patients underwent surgery 2 months after presentation because of slight enlargement of the lesion and increasing pain. After a median follow-up period of 1 year (range 6–19 months), none of the other patients had required surgery. Five of these 7 patients had pain at presentation. Pain resolved completely in all 5. The remaining 2 remained asymptomatic. Complete resolution of pain was reported in the 5 patients who had pain at presentation. There was complete clinical resolution of the palpable soft-tissue lesion in all 7 cases. Complete radiographic resolution of the lesion was observed in 5 cases and near-complete resolution in the remaining 2. Conclusions Observation is a safe and reasonable approach in the management of solitary calvarial EG and may prevent unnecessary surgical interventions.

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Section: Discussionmentioning

confidence: 99%

Nonoperative management of solitary eosinophilic granulomas of the calvaria

Angulo

Nair

Lee

et al. 2013

PED

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“…Possible causes include metastatic carcinoma, Langerhans cell histiocytosis, and brown tumors associated with hyperparathyroidism. [1][2][3] The combination of a retrothyroid mass and hyperparathyroidism suggested the existence of a benign or malignant lesion of the parathyroid gland with autonomous parathyroid hormone production. A presumptive diagnosis of primary hyperparathyroidism and multiple brown tumors due to a functional parathyroid mass was considered.…”

Section: Diagnosismentioning

confidence: 99%

Her Aching Bones: Atypical Parathyroid Adenoma

Rodrigues

Bekerman

Neves

et al. 2016

The American Journal of Medicine

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“…Sometimes an accompanying soft tissue mass is present. Occurrences of eosinophilic granuloma as a purely cortical lesion rarely are reported in the literature and are seen mainly in conjunction with multifocal disease [10]. To our knowledge, only one other case of a solitary surface eosinophilic granuloma has been reported [16].…”

Section: Discussion and Treatmentmentioning

confidence: 99%