Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis

Bhattacharjee, Pradip; Glusac, Earl J.

doi:10.1111/j.1600-0560.2006.00723.x

Cited by 48 publications

(37 citation statements)

References 18 publications

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“…This may indicate hypothetically that LCH arises in some conditions in a background of Langerhans cell hyperplasia or some of them are not even LCH. Similarly, some scabies infestations are demonstrated to be associated with Langerhans cell hyperplasia, which is totally cleared following the treatment of underlying pathology that is believed to cause an antigenic stimulus for epidermal Langerhans cells [14,15].…”

Section: Discussionmentioning

confidence: 98%

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Intestinal Langerhans Cell Histiocytosis-like Lesion in an Adult Presented with Diverticulitis: A Reactive or Neoplastic Condition?

Mete

Dogan

Kapran

et al. 2010

Pathol. Oncol. Res.

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The involvement of the gut by Langerhans cell histiocytosis (LCH) is very rare in adults; however this is usually observed with a disseminated disease in children. We report a 75-year-old male patient who underwent right hemicolectomy for a complicated intestinal diverticular disease. The surgical specimen revealed LCH-like proliferative lesion associated with diverticulitis. The overall morphological and immunohistochemical findings are indistinguishable from LCH. Systemic scans and subsequently performed bone marrow biopsies were free of disease. Although the HUMARA clonality assay cannot be assessed, the lack of evidence of LCH progression or disease elsewhere in the whole body strongly supported the possibility of an atypical reactive phenomenon probably due to the underlying intestinal diverticular disease. Therefore, it is important to avoid diagnosing such a unifocal Langerhans cell proliferation as LCH in patients with underlying pathologies in the absence of systemic involvement. Therefore, without knowledge of clonal status of a unifocal Langerhans cell proliferation, we recommend using the terminology of LCH-like lesion.

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Section: Discussionmentioning

confidence: 98%

“…The cause of LCH is still unknown [6], although there are some theories which have grown from the research conducted over the past few years. However, there is evidence that Langerhans cell proliferations represent a spectrum of disease that ranges from reactive to neoplastic phenomenon [12][13][14][15].…”

Section: Discussionmentioning

confidence: 98%

Intestinal Langerhans Cell Histiocytosis-like Lesion in an Adult Presented with Diverticulitis: A Reactive or Neoplastic Condition?

Mete

Dogan

Kapran

et al. 2010

Pathol. Oncol. Res.

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“…B lenfositler de belirgin olabilir. Lezyonlar bazen lenfomatoid papülozis, Hodgkin hastal›¤› ve non-Hodgkin lenfomay› taklit edebilir 12 . ‹nfiltrasyon içerisinde CD1a ve S100 pozitif çok say›da Langerhans hücresi bulunabilir.…”

Section: Tart›flmaunclassified

“…‹nfiltrasyon içerisinde CD1a ve S100 pozitif çok say›da Langerhans hücresi bulunabilir. Bu nedenle yanl›fll›kla Langerhans hücre histiyositozu tan›s› alan olgular bildirilmifltir 12,13 . Skabiyesli olgular›n deri biyopsilerinde yap›lan bir çal›flmada, uzun süren iltihabi infiltrasyonun bulundu¤u alanlarda CD 30+ büyük hücrelerin oldu¤u gösteril-mifltir 14 .…”

Section: Tart›flmaunclassified

A case of Scabies with Lesions Resembling Perforating Folliculitis and Uremic Pruritus

Akgün¹,

Akay²,

Kulluk³

et al. 2010

turkderm

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SummaryScabies is an infestation caused by Sarcoptes scabiei and characterised by polymorphous lesions that may include burrows, papules, pustules, crusts and excoriations. Several pruritic diseases may be confused with scabies. Herein, we present a case of scabies with lesions resembling perforating folliculitis diagnosed on the basis of both clinical and histopathological view. A 72-year-old man with type 2 diabetes mellitus and receiving hemodialysis for ten years due to end-stage renal disease was admitted to our dermatology department with a 6-month history of severe pruritus. Based on the results of skin biopsy revealing Sarcoptes scabiei in the epidermis, the patient was diagnosed as scabies and was successfully treated with 5% permethrin. This case is presented to emphasize that scabies should be considered in the differential diagnosis in cases of chronic pruritus. (Turkderm 2010; 44: 164-6)

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“…316 B-lymphoproliferative and Tlymphoproliferative disorders, as well as benign inflammatory skin conditions, including scabetic nodules, can demonstrate numerous Langerhans cells, requiring correlation with the clinicopathologic setting. 317,318 CUTANEOUS METASTASES Adenocarcinomas can metastasize to the skin, and rarely, that can be the first manifestation of the primary diagnosis. Identification of the site of origin has profound prognostic and therapeutic effect.…”

Section: Langerhans Cell Disordersmentioning

confidence: 99%

Immunohistochemistry in Dermatopathology

Ferringer

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Immunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context.Objective.-To review the current status and limitations of immunohistochemistry in dermatopathology.Data Sources.-English-language literature published between 1980 and 2014.Conclusions.-Although immunohistochemistry is rarely completely specific or sensitive, it is an important adjunctive technique in dermatopathology and can be helpful in a series of diagnostic dilemmas.

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Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis

Abstract: Because of the prominent CD1a+/S100+ component, scabies can mimic Langerhans cell histiocytosis. This finding should be considered in conjunction with scattered CD30+ cells and clinical features to avoid misdiagnosis.

Cited by 48 publications

References 18 publications

Intestinal Langerhans Cell Histiocytosis-like Lesion in an Adult Presented with Diverticulitis: A Reactive or Neoplastic Condition?

Intestinal Langerhans Cell Histiocytosis-like Lesion in an Adult Presented with Diverticulitis: A Reactive or Neoplastic Condition?

A case of Scabies with Lesions Resembling Perforating Folliculitis and Uremic Pruritus

Immunohistochemistry in Dermatopathology

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