Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen

Uchida, Kenzo; Kobayashi, Shigeru; Inukai, Tomoo; Noriki, Sakon; Imamura, Yoshiaki; Nakajima, Hideaki; Yayama, Takafumi; Orwotho, Norbert; Baba, H.

doi:10.1007/s00776-007-1184-4

Cited by 26 publications

(19 citation statements)

References 15 publications

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“…Classical hematological schemes, such as CHOP and ESHAP, have been administered, 7 and other drug combinations with Adriamycin plus Ifosfamide, such as MAID (mesna, doxorubicin, ifosfamide, dacarbazine) have also been tested. 9,11,12 Nevertheless, the best option for systemic treatment of LCS has not yet been established.…”

Section: Discussionmentioning

confidence: 98%

Langerhans cell sarcoma: Response to radiotherapy

Lucas

Barca

Servitje

et al. 2010

Reports of Practical Oncology & Radiotherapy

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Section: Discussionmentioning

confidence: 98%

Langerhans cell sarcoma: Response to radiotherapy

Lucas

Barca

Servitje

et al. 2010

Reports of Practical Oncology & Radiotherapy

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“…Local resection is commonly applied to isolated LCS lesions (Table I). Chemotherapies, such as a modified ESHAP (etoposide, carboplatin, cytarabine, and methylprednisolone) (20) and MAID (mesna, doxorubicin, ifosfamide, dacarbazine) (21) regimens, have been demonstrated to be effective in a proportion of patients. Radiotherapy has also been reported to be effective in certain cases.…”

Section: Discussionmentioning

confidence: 99%

Langerhans cell sarcoma originating from left knee subcutaneous tissue: A case report and literature review

Zhang

Fang

2016

Oncology Letters

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Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells with notably malignant cytological features. Reports of LCS are sparsely available in English literature; to the best of our knowledge, only 55 cases have been reported. The present study reports a case of LCS originating from subcutaneous tissue of the left knee in a 75-year-old man. The diagnosis of LCS was supported by the results of magnetic resonance imaging, histological and immunohistochemical studies. The tumor began to metastasize to inguinal lymph nodes and eventually involved multiple organs. Chemotherapy and radiotherapy were administered but were ineffective, and the patient died within 2 years of diagnosis. The present case should aid in expanding the currently available knowledge concerning LCS.

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“…Yoshimi et al [6] proposed a modified ESHAP program as salvage therapy if CHOP regimen fails. Uchida et al [14] reported a case in which MAID regimen successfully treated LCS emanating from the upper arm cutaneous tissue. Moreover, Ferringer et al [15] used doxorubicin and ifosfamide in an LCS patient to achieve complete remission in 3 months and no recurrence after 8 months of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cell Sarcoma in the Cervical Lymph Node: A Case Report and Literature Review

2012

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Langerhans cell sarcoma (LCS) is extremely rare, with only 36 cases reported in English literature. In this report we represent the case of a 77-year-old woman with a 1-month history of left neck swelling and pain. A diagnosis of LCS was rendered from pathological findings of the cervical lymph node biopsy. The patient’s condition deteriorated rapidly and she died 2 days after diagnosis. A literature review in the context of the present case was performed to better enhance understanding of the early diagnosis and treatment of this unusual lesion.

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Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen

Cited by 26 publications

References 15 publications

Langerhans cell sarcoma: Response to radiotherapy

Langerhans cell sarcoma: Response to radiotherapy

Langerhans cell sarcoma originating from left knee subcutaneous tissue: A case report and literature review

Langerhans Cell Sarcoma in the Cervical Lymph Node: A Case Report and Literature Review

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