Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity

Ambrosio, Maria Raffaella; Falco, Giulia De; Rocca, Bruno Jim; Barone, Aurora; Amato, Teresa; Bellan, Cristiana; Lazzi, Stefano; Leoncini, Lorenzo

doi:10.1007/s00428-015-1814-8

Cited by 27 publications

(16 citation statements)

References 37 publications

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“…Because identical IGH rearrangements were identified in both leukemia and LCS cells, they presumed an identical origin of these cells. Moreover, several cases of LCS having evolved from various hematologic malignancies, including hairy cell leukemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, and marginal-zone B-cell lymphoma, have been reported [16,17,18]. Cellular events or transcriptional factors involved in the development of LCS from various progenitor cells have not been identified.…”

Section: Discussionmentioning

confidence: 99%

A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing

Kim¹,

Choi

Han³

et al. 2017

Acta Haematol

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Langerhans cell histiocytosis (LCH) and Langerhans cell sarcoma (LCS) are clonal proliferations of Langerhans-type cells. Unlike in LCH, the pathophysiology and clinical course of LCS are unclear due to its rarity. Here, we report the case of a 73-year-old male patient who was diagnosed with cutaneous LCH and pulmonary LCS at the same time. Pathological review of these 2 tumors revealed similar immunohistochemical findings. However, the tumor cells in LCS had more aggressive cytological features than those in LCH. Results of BRAF mutation analysis using real-time PCR were negative for both tumors. In whole-exome sequencing (WES), stop-gain mutations in TP53 gene were discovered only in LCS cells. The mechanism of development of LCS from various progenitor cells is currently unclear. According to the results of the WES study, changes in TP53 gene might have contributed to the malignant features of LCS.

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Section: Discussionmentioning

confidence: 99%

A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing

Kim¹,

Choi

Han³

et al. 2017

Acta Haematol

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“…However, KRAS and BRAF gene mutations were not detected in our case. There have been several reports on LCS arising from other tumors of hematopoietic and lymphoid tissues 13, 14, 15, 16. However, there has been no report on LCS related to T‐cell/histiocyte‐rich large B‐cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…There have been several reports on LCS arising from other tumors of hematopoietic and lymphoid tissues. [13][14][15][16] However, there has been no report on LCS related to T-cell/histiocyterich large B-cell lymphoma. Some novel genetic mutations that can give rise to multiple neoplasms might have been hidden in his background.…”

Section: Discussionmentioning

confidence: 99%

Cytological findings of langerhans cell sarcoma in a case of quintuple cancer

Tabata

Murata

Takasawa

et al. 2017

Diagnostic Cytopathology

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Langerhans cell sarcoma (LCS) and quintuple cancers are extremely rare. In this report, a case of quintuple cancers including LCS was described. An 80‐year‐old man had squamous cell carcinoma of the nasal skin, colon and rectum adenocarcinomas, and T‐cell/histiocyte‐rich large B‐cell lymphoma. As swelling of multiple submental lymph nodes was observed, fine‐needle aspiration was carried out. Many large cells with high‐grade nuclear atypia and abundant cytoplasm were observed. Lymphocytes and eosinophils were observed in the background. Although a malignant tumor was suspected, a definite diagnosis could not be made. In a biopsy sample, the tumor cells were positive for vimentin, CD68, S‐100, CD1a, and CD163 and negative for epithelial, lymphocyte, and melanoma markers in immunohistochemistry. A diagnosis of LCS was made from the immunohistochemical findings and high mitotic rate with atypical forms. The patient died about 2 months after the first medical examination. Metastasis of LCS was confirmed in many organs by autopsy. LCS has a poor prognosis. In cases with the above‐described cytological findings, LCS should be added to the list of differential diagnosis. The cytological findings presented here may be useful for determining appropriate clinical management such as staging of the disease and follow‐up of the neoplasm. Diagn. Cytopathol. 2017;45:441–445. © 2017 The Authors Diagnostic Cytopathology Published by Wiley Periodicals, Inc.

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“…There are case reports of histiocytic and dendritic cell neoplasms synchronously or sequentially observed in patients with malignant lymphoma . Specifically, most cases are FL, splenic marginal zone B‐cell lymphoma, and marginal zone lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma have also been reported . Thus far, there have been more reports of sequential cases than synchronous cases.…”

mentioning

confidence: 99%

“…4 Specifically, most cases are FL, splenic marginal zone B-cell lymphoma, and marginal zone lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma have also been reported. [5][6][7][8] Thus far, there have been more reports of sequential cases than synchronous cases. In reports of histiocytic and dendritic cell neoplasms complicated by malignant lymphoma, the most commonly reported neoplasm is histiocytic sarcoma, followed by interdigitating cell sarcoma and Langerhans cell neoplasm.…”

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confidence: 99%

Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node

Shimono

Miyoshi

Abe

et al. 2018

Pathology International

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Langerhans cell sarcoma (LCS) is a very rare histiocytic and dendritic cell neoplasm originating from Langerhans cells. There are case reports of histiocytic and dendritic cell neoplasms synchronously or sequentially observed in patients with malignant lymphoma. We present a case in which LCS and follicular lymphoma (FL) grade 3a were observed within the same lymph node. A 66‐year‐old male visited our hospital with a general malaise. Pleural effusion and systemic lymph adenopathy were detected. Biopsy of an inguinal lymph node was performed. The lymph node had regions with follicular structure and regions with acidophilic cytoplasm and large proliferating atypical cells. The tumor cells in the regions with follicular structure showed positivity for CD20 and BCL2 consistent with an FL grade 3a diagnosis. The tumor cells in the regions without follicular structure showed positivity for CD1a and S‐100 and were consistent with an LCS diagnosis. Both tumor cells showed the positivity of BCL6 split by FISH. PCR detected IgH clonality in DNA collected from each region, and direct sequence analysis of cells from both tumors detected almost identical amino acid sequences. This finding is important for future research on the development of very rare histiocytic and dendritic cell neoplasms.

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Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity

Cited by 27 publications

References 37 publications

A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing

A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing

Cytological findings of langerhans cell sarcoma in a case of quintuple cancer

Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node

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