Langerhans'cell tumor of the eyelid

Warner, Thomas F.; Hafez, G. Reza

doi:10.1111/j.1600-0560.1982.tb01080.x

Cited by 9 publications

(2 citation statements)

References 15 publications

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“…8 Including this case, only 21 definitive cases of LCH involving the eyelids without changes to the underlying orbital bones have been published over 51 years (Table 1). The eyelid presentations followed 3 general patterns: eyelid masses (13/21), [9][10][11][12][13][14][15][16][17][18][19][20][21] chalazion-like lesions (4/21), [22][23][24][25] and periorbital swelling (3/21). 26,27 There is also one published case of eyelid soft tissue destruction.…”

Section: Discussionmentioning

confidence: 99%

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Plemel¹,

Benson²,

Tong³

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Langerhans cell histiocytosis (LCH) is a disorder of dendritic cell proliferation that typically involves bone. It can be diagnostically challenging when LCH presents without bony involvement, leading to delays in diagnosis and treatment. In this study, the periocular manifestations of LCH in cases where the underlying orbital bones are not involved are described through a systematic review. Methods: A systematic review of the literature was performed to capture all cases of LCH that involved the periocular region but not the underlying orbital bones. These included LCH cases that involved the periocular skin, the ocular surface, and the orbital tissue. The authors also highlight an additional case where LCH presented with periocular edema and multifocal, nodular conjunctival lesions. Result: This review illustrates that LCH rarely presents with periocular infiltration without orbital bone involvement. In these atypical cases, LCH can present as an eyelid mass, a chalazion-like lesion, generalized periocular swelling, ocular surface lesions, or infiltration of any orbital structure. Ocular surface LCH has a higher rate of recurrence than other periocular LCH. Orbital LCH can involve any tissue including extraocular muscles, the lacrimal gland, or indistinct areas within the orbit. Conclusions: LCH is a clinicopathologic diagnosis. Although most cases involve the bone, any soft tissue can be involved. Biopsy is required to confirm the diagnosis of this heterogeneous disease.

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Section: Discussionmentioning

confidence: 99%

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Plemel¹,

Benson²,

Tong³

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Although solitary ocular manifestations of LCH without evidence of systemic LCH are documented in children, they are rare in adults. The location of the infiltrate within the orbit largely determines the patient's presenting complaints . Most orbital manifestations of LCH in adults have been in the context of systemic LCH disease with only a handful of cases of solitary orbital LCH presenting as orbital cellulitis documented.…”

mentioning

confidence: 99%