Langerhans Cells Related to Prognosis in Patients With Laryngeal Carcinoma

Gallo, Oreste; Libonati, Giacinto Asprella; Gallina, Ezio; Fini-Storchi, O; Giannini, A. James; Urso, Carmelo; Bondi, R

doi:10.1001/archotol.1991.01870210079015

Cited by 85 publications

(70 citation statements)

References 25 publications

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“…Concerning Langerhans cells, a high density of these cells has been considered of favourable prognosis for patients with squamous cell carcinoma of the larynx in the univariate analysis (Gallo et al, 1991). However, we found a very small proportion of Langerhans cells in our cases with no influence on prognosis.…”

Section: Discussioncontrasting

confidence: 59%

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

Esteban

Redondo²,

Delgado³

et al. 1996

Br J Cancer

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Summary Alteration in MHC class I expression may be used by cancer cells to avoid immune destruction. Much experimental evidence supports this idea, although survival studies are very scarce. To investigate whether the presence or absence of HLA-A, -B and -C antigens in laryngeal carcinoma influences survival, a series of 60 primary laryngeal tumours treated surgically and normal tissues were evaluated in frozen sections for the expression of MHC class I antigens and tumour-infiltrating leucocytes (CD3, CD4, CD8, CD1Ib, CD1, CD20 and CDI6), using monoclonal antibodies and the APAAP technique. Long-term follow-up from the patients is available, ranging from 6 to 10 years. Thirteen tumours presented total HLA-ABC loss, five selective losses of HLA-A antigens and one absence of HLA-B antigens. Total losses were statistically associated with several clinical and pathological parameters, but there were no differences regarding tumour-infiltrating leucocytes. After conducting a prospective study, only T and N staging and scoring according to Glanz's malignancy classification were found to be independently related to patients' outcome. From our data, we conclude that neither complete loss of HLA class I antigens nor tumour-infiltrating leucocytes appear to influence survival in squamous cell carcinoma of the larynx.

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Section: Discussioncontrasting

confidence: 59%

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

Esteban

Redondo²,

Delgado³

et al. 1996

Br J Cancer

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“…Schenk (1980) demonstrated the presence of Langerhans cells in squamous cell carcinoma of the larynx identified by ultrstructural examination of cytoplasmic granules (Langerhans granules or Birbeck's granules). Gallo et al (1991) noted the presence of Langerhans cells in squamous cell carcinoma of the larynx using the polyclonal antibody against S-100 protein. Thompson and Griffin (1994) …”

Section: Introductionmentioning

confidence: 99%

Langerhans Cells in the Larynx and the Hypopharynx.

Sato

Hirano

1997

Kurume Med. J.

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Summary: Langerhans cells are important in the human immune system as a part of the dendrtic cell system. This study was carried out to demonstrate the presence of Langerhans cells and their distribution in normal human larynx and hypopharynx, by light (S-100 polyclonal antibody) and transmission electron microscopy. The results are summarized as follows: 1) Langerhans cells with cytoplasmic granules (Langerhans granules or Birbeck's granules) were situated in the suprabasal region of the squamous epithelium in the larynx and the hypopharynx. 2) They distributed in the membranous portion of the vocal folds, epiglottis, aryepiglottic folds, arytenoid regions and interarytenoid notch of the larynx. The cells surrounded the vestibule and glottis of the larynx. 3) They distributed in the postcricoid area, piriform sinus and posterior pharyngeal wall of the hypopharynx. The cells were situated above the entrance of esophagus. 4) The cells were suggested to be a factor of immune response at the entrance of trachea and esophagus. Key wordsLangerhans cell, immunology of larynx and hypopharynx, histology of larynx and hypopharynx, vocal folds, larynx, hypopharynx

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“…In recent years, attention has been focused on the den dritic T-zone accessory cells -identified immunocytochemically by the expression of CD la and S-100 anti gens -in the infiltrates of the connective tissue adjacent to adenocarcinomas of the lung [1,2], stomach [3] and colon [4], nasopharyngeal carcinomas [5], papillary' car cinomas of the thyroid [6] and malignant melanomas of the skin [7], It has been observed that the higher the number of T-zone accessory cells, the more favourable the prognosis was. and it has been suggested that these cells had an important role in setting up an immune response against tumours [5][6][7], A correlation between a high number of dendritic accessory' cells identified immunocytochemically in the peritumoral infiltrates and favourable prognosis has also been reported for laryngeal carcinomas [8],…”

Section: Introductionmentioning

confidence: 96%

Interdigitating Cells in the Peritumoral Infiltrate of Laryngeal Carcinomas: An Immunocytochemical and Ultrastructural Study

Rucci

Bani²,

Gallo³

et al. 1991

ORL

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Interdigitating cells (IDCs) have been found in the peritumoral infiltrate of 18 patients with squamous cell carcinoma of the larynx. These cells have a dendritic shape and are characterized by the expression of S-100 protein and CD la antigens. By electron microscopy, these cells are seen to establish intimate contacts with the apposed lymphocytes, which sometimes show signs of functional activation and proliferation. These findings indicate that IDCs may play a role in setting up a T-cell immune reaction against neoplastic cells, which may influence the biological behaviour and/or local growth of the tumour. Moreover, monocytes and cells with intermediate features between monocytes and IDCs are also found in the peritumoral infiltrate, thus suggesting that IDCs differentiate in situ from monocytic precursors, possibly under the influence of either tumour-derived factors or the local lymphoid microenvironment.

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Langerhans Cells Related to Prognosis in Patients With Laryngeal Carcinoma

Cited by 85 publications

References 25 publications

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

Langerhans Cells in the Larynx and the Hypopharynx.

Interdigitating Cells in the Peritumoral Infiltrate of Laryngeal Carcinomas: An Immunocytochemical and Ultrastructural Study

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