Langfristiger Streß und Herpes-simplex-Antikörper bei gesunden Probanden

Changes of Immunological Parameters in Healthy Subjects Under Examination Stress

“…The mean anxiety scores in the student sample were considerably higher at T, in comparison with the mean anxiety-scores in the population used for standardization of this test (for details of psychological testings and results see Fittschen, Schulz, Schulz, Raedler & Kerekjarto, 1989).…”

“…Immunological parameters in our study, therefore, were: (a) the percentage of large immunocytes (LI) in the population of peripheral immunocytes (determination described in Schulz et al, 1989b) (b) the concentration of neopterin in the urine of our subjects (determination kindly done by Prof. Dr. Wachter and Dr. Fuchs, University of Innsbruck, Austria) and (c) the titer of antibodies against herpes-simplex (HSV-Ab) regardless of subtype in the serum of latently infected subjects (determination described in Fittschen et al, 1989).…”

Overview of psychoneuroimmunological stress‐ and intervention studies in humans with emphasis on the uses of immunological parameters

“…Another problem often ignored in the discussions of PNI-studies is the difference between in vivo and in vitro measures of immune function. Moreover the concept of immunosuppression as a natural consequence of stressor exposure is brought into question by the results of some human studies (Landmann et al, 1984;Zautra, Okun, Robinson, Lee, Roth and Emmanual, 1989;Fittschen, Schulz, Schulz, Raedler and Kerekjarto, 1989) and animal studies (Berkenbosch, Heijnen, Croiset, Revers, Ballieux, Binnekade and Tilders, 1986;Jessop, Gale and Bayer, 1987;Croiset, Heijnen, Veldhuis, de Wied and Ballieux, 1987;Schulz, Lenz, Messmer, Siemen and Raedler, 1989;Weiss, Sundar and Becker, 1989), which have shown an increase in some immune functions following stressor exposure. Depending on certain conditions (for example mild or acute stressors) and/or the immunological variables chosen (NK-cells, Bcells, immunoglobulins) an enhancing effect of stress on the particular immune function can be demonstrated.…”