Langmuir Monolayer Miscibility of Perfluorocarboxylic Acids with Biomembrane Constituents at the Air-Water Interface

Nakahara, Hiromichi; Shibata, Osamu

doi:10.5650/jos.61.197

Cited by 16 publications

(16 citation statements)

References 84 publications

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“…11,27 Limiting molecular areas (A 0 ) for the pure components, estimated by extrapolating the pseudolinear portion of the liquid-condensed phase to the mean molecular area axis intercept, were ∼61 and ∼34 Å 2 ·molecule −1 for DPPC and C18F, respectively. As an aside, Nakahara and Shibata 24 have commented that perfluorocarboxylic acids from commercial sources can contain significant impurities (certified purity of C18F from Alfa Aesar used here was reported as ∼97%) and have suggested that these impurities can result in A 0 values that are unreasonably large in comparison with those estimated from the cross-section of a perfluorocarbon chain (∼28 Å 2 ). Further, the authors suggest that multiple recrystallizations of these materials are necessary for meaningful quantitative measurements.…”

Section: Resultsmentioning

confidence: 93%

Influence of Film Composition on the Morphology, Mechanical Properties, and Surfactant Recovery of Phase-Separated Phospholipid-Perfluorinated Fatty Acid Mixed Monolayers

2012

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Monolayer surfactant films composed of a mixture of phospholipids and perfluorinated (or partially fluorinated) surfactants are of potential utility for applications in pulmonary lung surfactant-based therapies. As a simple, minimal model of such a lung surfactant system, binary mixed monolayer films composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and perfluorooctadecanoic acid (C18F) prepared on a simplified lung fluid mimic subphase (pH 7.4, 150 mM NaCl) have been characterized in terms of mixing thermodynamics and compressibility (measured through π–A compression isotherms), film morphology (via atomic force, fluorescence, and Brewster angle microscopy), as well as spreading rate and hysteresis response to repeated expansion–contraction cycles for a variety of compositions of mixed films. Under all mixing conditions, films and their components were found to be completely immiscible and phase-separated, though there were significant changes in the aforementioned film properties as a function of composition. Of particular note was the existence of a maximum in the extent of immiscibility (characterized by ΔG(ex)(π) values) and enhanced surfactant recovery during hysteresis experiments at χ(C18F) ≥ 0.30. The latter was attributed to the relatively rapid respreading rate of the perfluorinated amphiphile in comparison with DPPC alone at the air–water interface, which enhances the performance of this mixture as a potential pulmonary lung surfactant. Further, monolayer film structure could be tracked dynamically as a function of compression at the air–water interface via Brewster angle microscopy, with the C18F component being preferentially squeezed out of the film with compression, but returning rapidly upon re-expansion. In general, addition of C18F to DPPC monolayers resulted in improvements to mechanical, structural, and respreading properties of the film, indicating the potential value of these compounds as additives to pulmonary lung surfactant formulations.

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Section: Resultsmentioning

confidence: 93%

Influence of Film Composition on the Morphology, Mechanical Properties, and Surfactant Recovery of Phase-Separated Phospholipid-Perfluorinated Fatty Acid Mixed Monolayers

2012

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“…Highly fluorinated compounds have a tendency to accumulate in the environment and in the human body 5 8 . A detailed description of the interfacial behavior and interaction of perfluorocarboxylic acid with dipalmitoylphosphatidylcholine DPPC , which is a major component in pulmonary surfactants, can be found in a previously published review article 9 . Perfluorooctyl bromide PFOB, n F 8 has been investigated for its potential use in oxygen delivery and has exhibited short organ retention times 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Monolayer Compression Induces Fluidization in Binary System of Partially Fluorinated Alcohol (F4H11OH) with DPPC

et al. 2013

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“…As mentioned above, the solidification of DPPC monolayers induced by the F8H9OH addition results from the decrease in π eq against X F8H9OH . Therefore, the slope of ∂π eq /∂X can be considered to express the degree of the solidification negative or fluidization positive 8,26 . The inclination for the DPPC/F8H9OH system 0 The experimental π c values also vary against X F8H9OH .…”

Section: Two-dimensional Phase Diagramsmentioning

confidence: 99%

Two-Component Langmuir Monolayers and LB Films of DPPC with Partially Fluorinated Alcohol (F8H9OH)

2013

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Langmuir Monolayer Miscibility of Perfluorocarboxylic Acids with Biomembrane Constituents at the Air-Water Interface

Cited by 16 publications

References 84 publications

Influence of Film Composition on the Morphology, Mechanical Properties, and Surfactant Recovery of Phase-Separated Phospholipid-Perfluorinated Fatty Acid Mixed Monolayers

Influence of Film Composition on the Morphology, Mechanical Properties, and Surfactant Recovery of Phase-Separated Phospholipid-Perfluorinated Fatty Acid Mixed Monolayers

Monolayer Compression Induces Fluidization in Binary System of Partially Fluorinated Alcohol (F4H11OH) with DPPC

Two-Component Langmuir Monolayers and LB Films of DPPC with Partially Fluorinated Alcohol (F8H9OH)

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