Language and reading comprehension in middle childhood predicts emotional and behaviour difficulties in adolescence for those with permanent childhood hearing loss

Stevenson, Jim; Pimperton, Hannah; Kreppner, Jana; Worsfold, Sarah; Terlektsi, Emmanouela; Mahon, Merle; Kennedy, Colin

doi:10.1111/jcpp.12803

Cited by 18 publications

(13 citation statements)

References 63 publications

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“…The auditory system involves a series of complex distributed cerebral networks and its impairment affects psychosocial, emotional and cognitive development (Stevenson et al, 2018). Hearing-impaired children are at increased risk for learning disabilities (S. M. R. Choi, Kei, & Wilson, 2020) and even within the normal range, better hearing has been associated with better reading skills, working memory and nonverbal IQ in a sample of 1,638 UK school children (Moore, Zobay, & Ferguson, 2019).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association study and polygenic risk score analysis for hearing measures in children

Schmitz

Abbondanza

Paracchini

2020

Preprint

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An efficient auditory system contributes to cognitive and psychosocial development. A right ear advantage in hearing thresholds (HT) has been described in adults and atypical patterns of left/right hearing threshold asymmetry (HTA) have been described for psychiatric and neurodevelopmental conditions. Previous genome-wide association studies (GWAS) on HT have mainly been conducted in elderly participants whose hearing is more likely to be affected by environmental effects. We analysed HT and HTA in a children population cohort (ALSPAC, n = 6,743, 7.6 years). Better hearing was associated with more advanced cognitive skills and higher socioeconomic status (SES). Mean HTA was negative (−0.28 dB), suggesting a left ear advantage in children but mainly driven by females (−0.48 dB in females v -0.09 dB in males). We performed the first GWAS on HT in children and the very first GWAS on HTA (n = 5,344). Single marker trait association analysis did not yield significant hits. Polygenic risk score (PRS) analysis revealed associations of PRS for schizophrenia with HT, which remained significant after controlling for SES and cognitive skills, and of PRS for autism spectrum disorders (ASD) with HTA. Gene-based analysis for HTA reached genome-wide significance for MCM5, which is implicated in axon morphogenesis. This analysis also highlighted other genes associated with contralateral axon crossing. Some of these genes have previously been reported for ASD. These results further support the hypothesis that pathways distinguishing the left/right axis of the brain (i.e. commissural crossing) contribute to both different types of asymmetries (i.e. HTA) and neurodevelopmental disorders.

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Section: Introductionmentioning

confidence: 99%

Genome-wide association study and polygenic risk score analysis for hearing measures in children

Schmitz

Abbondanza

Paracchini

2020

Preprint

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“…A recent psychometric evaluation of the HUI3 and PedsQL TM Version 4.0 Generic Core Scales in Australian pre-school children with low language or congenital hearing loss found that the PedsQL TM may not be as sensitive as the HUI3 in distinguishing HRQoL impairments in children with and without low language [37]. It is likely that the hearing and speech attributes of the HUI3 allow it to be particularly sensitive at detecting the specific effects of hearing and language losses on the daily lives of children and adolescents, while the PedsQL may be more sensitive to social aspects of HRQoL that are particularly salient in these adolescents [22][23][24]. The HUI3 and PedsQL TM Version 4.0 Generic Core Scales are each underpinned by distinct conceptual models with distinct attribute sets and scoring algorithms and as such should be viewed as complementary tools for assessing the HRQoL of children or adolescents with PCHL.…”

Section: Discussionmentioning

confidence: 99%

“…The normally hearing comparison group had been identified using an algorithm developed by the investigators based on the dates of birth of the required number of children with normal hearing within each district and for each screening period. Further assessment of the sample was undertaken in the Hearing Outcomes at Teen Age project at a mean age of 16.9 (SD: 1.4) years [18][19][20][21][22][23][24].…”

Section: Study Background and Samplementioning

confidence: 99%

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Bilateral Permanent Childhood Hearing Loss and Health-Related Quality of Life in Adolescence

2021

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Little is known about the impact of bilateral permanent childhood hearing loss (PCHL) on health-related quality of life (HRQoL). The objective of this study was to describe preference-based and non-preference based HRQoL outcomes in adolescence, from both self and proxy perspectives, amongst participants of the Hearing Outcomes Project. The Health Utilities Index Marks II (HUI2) and III (HUI3) and the PedsQLTM Version 4.0 Generic Core Scales were used to measure HRQoL based on self and parent proxy reports in 114 adolescents aged 13–19 years, 76 with bilateral PCHL and 38 with normal hearing, recruited from a population sample that was followed up from birth to adolescence. Descriptive statistics and multivariable analyses were used to estimate the relationship between severity of PCHL and HRQoL outcomes. PCHL was associated with decrements in mean multi-attribute utility score that varied between 0.078 and 0.148 for the HUI2 (p = 0.001) and between 0.205 and 0.315 for the HUI3 (p < 0.001), dependent upon the national tariff set applied and respondent group. Multivariable analyses revealed that, after controlling for clinical and sociodemographic covariates, mean HUI3 multi-attribute utility scores were significantly lower in adolescents with moderately severe, severe and profound hearing loss than in adolescents with normal hearing. Significant differences in physical functioning, social functioning, psychosocial functioning and total PedsQLTM scores were only observed when assessments by parents were relied upon, but these dissipated in the multivariable analyses. Bilateral PCHL is associated with poorer HRQoL outcomes in adolescence. Further studies conducted are needed to understand the trajectory and underpinning mechanisms of HRQoL outcomes following PCHL.

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“…Eigsti and colleagues 24 demonstrated, in a sample of internationally adopted children aged 4–13 years, that top-down cognitive assessments including measures of explicit memory and cognitive control differed between children who experienced early IC and matched children from biological families, yet differences between the groups in bottom-up implicit learning processes were unremarkable. Thus, although the results are complex, they have important implications for our understanding of the unique needs of this population given the critical role of language as a higher-order ability that underlies communication, learning, and self-regulation, and its strong predictive power with respect to outcomes in a variety of domains for typically developing and vulnerable populations 25 – 28 .…”

Section: Introductionmentioning

confidence: 99%

Language Outcomes in Adults with a History of Institutionalization: Behavioral and Neurophysiological Characterization

Kornilov

Zhukova

Ovchinnikova

et al. 2019

Sci Rep

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Impoverished early care environments are associated with developmental deficits in children raised in institutional settings. Despite the accumulation of evidence regarding deficits in general cognitive functioning in this population, less is known about the impact of institutionalization on language development at the level of brain and behavior. We examined language outcomes in young adults and adolescents raised in institutions (n = 23) as compared to their socioeconomic status and age peers raised in biological families (n = 24) using a behavioral language assessment and linguistic event-related potentials (ERPs). Controlling for intelligence, adults with a history of institutionalization demonstrated deficits in lexical and grammatical development and spelling. Analyses of ERP data revealed significant group differences in the dynamic processing of linguistic stimuli. Adults with a history of institutionalization displayed reduced neural sensitivity to violations of word expectancy, leading to reduced condition effects for temporo-spatial factors that tentatively corresponded to the N200, P300/N400, and phonological mismatch negativity. The results suggest that language is a vulnerable domain in adults with a history of institutionalization, the deficits in which are not explained by general developmental delays, and point to the pivotal role of early linguistic environment in the development of the neural networks involved in language processing.

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Language and reading comprehension in middle childhood predicts emotional and behaviour difficulties in adolescence for those with permanent childhood hearing loss

Cited by 18 publications

References 63 publications

Genome-wide association study and polygenic risk score analysis for hearing measures in children

Genome-wide association study and polygenic risk score analysis for hearing measures in children

Bilateral Permanent Childhood Hearing Loss and Health-Related Quality of Life in Adolescence

Language Outcomes in Adults with a History of Institutionalization: Behavioral and Neurophysiological Characterization

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