Language and reading impairments are associated with increased prevalence of non‐right‐handedness

Abbondanza, Filippo; Dale, Philip S.; Wang, Carol A.; Hayiou‐Thomas, Marianna E.; Toseeb, Umar; Koomar, Tanner; Wigg, Karen; Feng, Yu; Price, Kaitlyn M.; Kerr, Elizabeth; Guger, Sharon; Lovett, Maureen W.; Strug, Lisa J.; Bergen, Elsje van; Dolan, Conor V.; Tomblin, J. Bruce; Moll, Kristina; Schulte‐Körne, Gerd; Neuhoff, Nina; Warnke, Andreas; Fisher, Simon E.; Barr, Cathy L.; Michaelson, Jacob; Boomsma, Dorret I.; Snowling, Maggie; Hulme, Charles; Whitehouse, Andrew; Pennell, Craig E.; Newbury, Dianne F.; Stein, John; Talcott, Joel B.; Bishop, Dorothy; Paracchini, Silvia

doi:10.1111/cdev.13914

Cited by 13 publications

(5 citation statements)

References 130 publications

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“…Here, genetic variants of genes related to language networks were linked to altered functional brain asymmetry [30]. In line with that, higher rates of non-right-handedness have been confirmed in children with language and/ or reading impairments by meta-analysis [31]. However, altered asymmetries in brain regions relevant to language processing have also been found in patients with schizophrenia [32], instead supporting that atypical asymmetries may be linked to symptoms rather than to a specific diagnosis.…”

Section: Introductionsupporting

confidence: 71%

Handedness in schizophrenia and affective disorders: a large-scale cross-disorder study

Mundorf,

Lischke,

Peterburs

et al. 2024

Eur Arch Psychiatry Clin Neurosci

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While most people are right-handed, a minority are left-handed or mixed-handed. It has been suggested that mental and developmental disorders are associated with increased prevalence of left-handedness and mixed-handedness. However, substantial heterogeneity exists across disorders, indicating that not all disorders are associated with a considerable shift away from right-handedness. Increased frequencies in left- and mixed-handedness have also been associated with more severe clinical symptoms, indicating that symptom severity rather than diagnosis explains the high prevalence of non-right-handedness in mental disorders. To address this issue, the present study investigated the association between handedness and measures of stress reactivity, depression, mania, anxiety, and positive and negative symptoms in a large sample of 994 healthy controls and 1213 patients with DSM IV affective disorders, schizoaffective disorders, or schizophrenia. A series of complementary analyses revealed lower lateralization and a higher percentage of mixed-handedness in patients with major depression (14.9%) and schizophrenia (24.0%) compared to healthy controls (12%). For patients with schizophrenia, higher symptom severity was associated with an increasing tendency towards left-handedness. No associations were found for patients diagnosed with major depression, bipolar disorder, or schizoaffective disorder. In healthy controls, no association between hand preference and symptoms was evident. Taken together, these findings suggest that both diagnosis and symptom severity are relevant for the shift away from right-handedness in mental disorders like schizophrenia and major depression.

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Section: Introductionsupporting

confidence: 71%

Handedness in schizophrenia and affective disorders: a large-scale cross-disorder study

Mundorf,

Lischke,

Peterburs

et al. 2024

Eur Arch Psychiatry Clin Neurosci

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“…Regarding hemispheric specialization of language, our sample was overwhelmingly right‐handed. While we did not formally evaluate language dominance with functional MRI or an invasive Wada procedure, 95% of right‐handed individuals display left hemisphere language dominance, whereas 70% of left‐handed individuals display left hemisphere dominance, as well 56 . One possibility is that patients with variable degrees of right hemisphere language dominance might be adversely affected by right STN DBS, but inclusion of the small number of left‐handed and ambidextrous participants in our sample did not impact our group‐level findings.…”

Section: Discussionmentioning

confidence: 99%

Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease

Del Bene,

Martin,

Brinkerhoff

et al. 2024

Annals of Neurology

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ObjectiveThe aim of this study was to investigate the cognitive effects of unilateral directional versus ring subthalamic nucleus deep brain stimulation (STN DBS) in patients with advanced Parkinson's disease.MethodsWe examined 31 participants who underwent unilateral STN DBS (left n = 17; right n = 14) as part of an National Institutes of Health (NIH)‐sponsored randomized, double‐blind, crossover study contrasting directional versus ring stimulation. All participants received unilateral DBS implants in the hemisphere more severely affected by motor parkinsonism. Measures of cognition included verbal fluency, auditory‐verbal memory, and response inhibition. We used mixed linear models to contrast the effects of directional versus ring stimulation and implant hemisphere on longitudinal cognitive function.ResultsCrossover analyses showed no evidence for group‐level changes in cognitive performance related to directional versus ring stimulation. Implant hemisphere, however, impacted cognition in several ways. Left STN participants had lower baseline verbal fluency than patients with right implants (t [20.66 = −2.50, p = 0.02]). Verbal fluency declined after left (p = 0.013) but increased after right STN DBS (p < 0.001), and response inhibition was faster following right STN DBS (p = 0.031). Regardless of hemisphere, delayed recall declined modestly over time versus baseline (p = 0.001), and immediate recall was unchanged.InterpretationDirectional versus ring STN DBS did not differentially affect cognition. Similar to prior bilateral DBS studies, unilateral left stimulation worsened verbal fluency performance. In contrast, unilateral right STN surgery increased performance on verbal fluency and response inhibition tasks. Our findings raise the hypothesis that unilateral right STN DBS in selected patients with predominant right brain motor parkinsonism could mitigate declines in verbal fluency associated with the bilateral intervention. ANN NEUROL 2024

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“…Likewise, in children no consistent patterns arise from the literature associating direction of bias and cognitive ability even when neurodiverse populations are involved. A recent meta-analysis of individuals (6–19 years) revealed a significant association between non-right-handedness and reading/language impairments 63 , while a systematic review including children (ages 5.1–38.7 years) found no consistent differences in direction of handedness for autistic and non-autistic populations 64 .…”

Section: Introductionmentioning

confidence: 98%

Motor-sensory biases are associated with cognitive and social abilities in humans

Donati,

Edginton,

Bardo

et al. 2024

Sci Rep

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Across vertebrates, adaptive behaviors, like feeding and avoiding predators, are linked to lateralized brain function. The presence of the behavioral manifestations of these biases are associated with increased task success. Additionally, when an individual’s direction of bias aligns with the majority of the population, it is linked to social advantages. However, it remains unclear if behavioral biases in humans correlate with the same advantages. This large-scale study (N = 313–1661, analyses dependent) examines whether the strength and alignment of behavioral biases associate with cognitive and social benefits respectively in humans. To remain aligned with the animal literature, we evaluate motor-sensory biases linked to motor-sequencing and emotion detection to assess lateralization. Results reveal that moderate hand lateralization is positively associated with task success and task success is, in turn, associated with language fluency, possibly representing a cascade effect. Additionally, like other vertebrates, the majority of our human sample possess a ‘standard’ laterality profile (right hand bias, left visual bias). A ‘reversed’ profile is rare by comparison, and associates higher self-reported social difficulties and increased rate of autism and/or attention deficit hyperactivity disorder. We highlight the importance of employing a comparative theoretical framing to illuminate how and why different laterization profiles associate with diverging social and cognitive phenotypes.

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Language and reading impairments are associated with increased prevalence of non‐right‐handedness

Cited by 13 publications

References 130 publications

Handedness in schizophrenia and affective disorders: a large-scale cross-disorder study

Handedness in schizophrenia and affective disorders: a large-scale cross-disorder study

Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease

Motor-sensory biases are associated with cognitive and social abilities in humans

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