Language comprehension vs. language production: Age effects on fMRI activation

Lidzba, Karen; Schwilling, E.; Grodd, Wolfgang; Krägeloh-Mann, I.; Wilke, Marko

doi:10.1016/j.bandl.2011.02.003

Cited by 107 publications

(97 citation statements)

References 71 publications

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“…Early ASO is more likely than late ASO to be accompanied by atypical language lateralization (Brázdil et al, 2003). This effect is consistent with the normal language development (i.e., increased hemispheric specialization with age for both language production and comprehension; Holland et al, 2001;Plante et al, 2006;Szaflarski et al, 2006;Ressel et al, 2008;Lidzba et al, 2011). However, there is no consensus on exactly how ASO affects language reorganization.…”

Section: Interindividual Factorssupporting

confidence: 49%

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Baciu

Perrone‐Bertolotti

2015

Reviews in the Neurosciences

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AbstractThe objective of this review is to resume major neuroimaging findings on language organization and plasticity in patients with focal and refractory epilepsy, to discuss the effect of modulatory variables that should be considered alongside patterns of reorganization, and to propose possible models of language reorganization. The focal and refractory epilepsy provides a real opportunity to investigate various types of language reorganization in different conditions. The ‘chronic’ condition (induced by the epileptogenic zone or EZ) is associated with either recruitment of homologous regions of the opposite hemisphere or recruitment of intrahemispheric, nonlinguistic regions. In the ‘acute’ condition (neurosurgery and EZ resection), the initial interhemispheric shift (induced by the chronic EZ) could follow a reverse direction, back to the initial hemisphere. These different patterns depend on several modulatory factors and are associated with various levels of language performance. As a neuroimaging tool, functional magnetic resonance imaging enables the detailed investigation of both hemispheres simultaneously and allows for comparison with healthy controls, potentially creating a more comprehensive and more realistic picture of brain-language relations. Importantly, functional neuroimaging approaches demonstrate a good degree of concordance on a theoretical level, but also a considerable degree of individual variability, attesting to the clinical importance with these methods to establish, empirically, language localization in individual patients. Overall, the unique features of epilepsy, combined with ongoing advances in technology, promise further improvement in understanding of language substrate.

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Section: Interindividual Factorssupporting

confidence: 49%

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Baciu

Perrone‐Bertolotti

2015

Reviews in the Neurosciences

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“…While there was a correlation between verbal IQ and the hemispheric functional lateralization index obtained by fMRI during language comprehension, the correlation was absent between verbal IQ and hemispheric asymmetries during language production. In addition, better performances were associated with larger right hemisphere participation (Lidzba et al 2011).…”

Section: Cognitive Skills and Asymmetriesmentioning

confidence: 95%

Intra- and Inter-hemispheric Connectivity Supporting Hemispheric Specialization

Tzourio‐Mazoyer

2016

Research and Perspectives in Neurosciences

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Hemispheric specialization (HS), or hemispheric dominance, is a nineteenth century concept that relates to the fact that a given hemisphere is the pilot of a given function such as, for example, the left hemisphere is dominant for language and for right-handedness. HS is grounded in both intra-hemispheric white matter connections, supported by associative bundles, and inter-hemispheric connections between cortical areas located in mirrored positions (homotopic), through the corpus callosum (CC) fiber tracts. Imaging investigations have measured anatomical and/or functional asymmetry, assessing HS at the voxelwise, regional, or hemispheric level. Comparison of these simple measures obtained with functional imaging during language tasks with results from the Wada test has validated that asymmetries do size up HS and pave the way for the investigation of HS in healthy humans. Anatomical asymmetries explain only a fraction of functional variability in lateralization, likely because structural and functional asymmetries develop at different periods of life. Anatomical asymmetries appear as early as the 26th week of gestation; at birth they are identical to those of adults. In contrast, functional neuroimaging investigations have revealed that inter-hemispheric connectivity appears at birth and is leftward asymmetrical in auditory areas, whereas in highorder language areas, this inter-hemispheric connectivity slowly shifts during development to a predominant intra-hemispheric connectivity in the adult. The precise timing and neural basis of this shift are still unknown, but it has been nevertheless shown that the connectivity is not yet in place at the age of seven and that it parallels an increase in leftward asymmetry during language tasks. Abnormal development of this asymmetry is observed in severe mental illnesses that exhibit language symptoms, such as schizophrenia and autism. In addition, after a dominant hemisphere lesion, good language capacities are associated with the recovery of a leftward asymmetry during language tasks. However, neuroimaging studies have shown that HS variability for language, up to rightward dominance, exists in healthy individuals and is partly explained by both behavioral (handedness) and anatomical (i.e., brain volume, size of the left planum temporale) factors, with these factors possibly interacting with one another. Knowledge of the setting up of N. Tzourio-Mazoyer (*)

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“…Furthermore, producing a metaphor explanation might engage more cognitive and executive functions than comprehension and application of meanings, semantics might be more demanding than just comprehending them. A recent fMRI study of language comprehension and production (Lidzba, Schwilling, Grodd, Krageloh-Mann, & Wilke, 2011) showed that language comprehension is represented more bilaterally than language production, and, most frequently, there is a hemispheric dissociation with left-hemispheric language production. Hence, it could be hypothesized that to explain metaphors, one has to comprehend and then interpret them, so one has to engage more brain regions.…”

Section: Discussionmentioning

confidence: 99%

Metaphor Processing in Schizophrenia Patients: A Study of Comprehension and Explanation of Metaphors

Pawełczyk

Łojek

Pawełczyk

2017

Psychology of Language and Communication

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The study assessed the quantity and quality of errors made by schizophrenia patients in understanding and interpretation of the same metaphors, to evaluate metaphor understanding and explanation depending on the type of presentation material, and to analyze the correlation of illness symptoms with metaphor comprehension and explanation. Two groups of participants were examined: a schizophrenia sample (40 participants) and a control group (39 participants). Metaphor processing was assessed by the subtests of the Polish version of the Right Hemisphere Language Battery (RHLB-PL). The patients were also evaluated with the Positive and Negative Syndrome Scale (PANSS). Schizophrenia patients scored significantly lower in explanation of metaphors, making more incorrect literal and abstract mistakes or providing no answer more frequently. No differences were observed in understanding metaphors; no correlation between symptoms and metaphor processing was obtained. In both groups, picture metaphors were easier to comprehend and written metaphors were easier to comprehend than to explain.

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Language comprehension vs. language production: Age effects on fMRI activation

Cited by 107 publications

References 71 publications

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Intra- and Inter-hemispheric Connectivity Supporting Hemispheric Specialization

Metaphor Processing in Schizophrenia Patients: A Study of Comprehension and Explanation of Metaphors

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