Language development of children born following intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)

D’haeseleer, Evelien; Meerschaut, Frauke Vanden; Bettens, Kim; Luyten, Anke; Gysels, Hannelore; Thienpont, Ylenia; Witte, Griet De; Heindryckx, Björn; Oostra, Ann; Roeyers, Herbert; Sutter, Petra De; Lierde, Kristiane Van

doi:10.1111/1460-6984.12100

Cited by 24 publications

(14 citation statements)

References 27 publications

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“…Until now, the few studies on the outcome of children born after the use of calcium ionophore report neonatal and neurodevelopmental outcomes within the normal range [8,9]. Miller et al [10] reported six birth defects in 62 (9.6%) children born after oocyte activation with ionophore A23187 (calcimycin), but this number was not statistically different from the 6.1% (26/426) children after ICSI without oocyte activation in their study.…”

Section: Introductionmentioning

confidence: 72%

“…Firstly, due to its specific indication, the number of patients that may benefit from this technique is rather small, leading to a low number of children born after transfer of an embryo obtained after oocyte activation. While we described the medical outcome of 47 children conceived at our center, only two other reports on medical follow-up of children born after AOA are available in literature, both from the same group [8,9]. Obviously, the described number of children should be much higher in order to draw firm conclusions regarding the safety of AOA for the offspring, particularly regarding congenital malformations.…”

Section: Discussionmentioning

confidence: 99%

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Obstetric and neonatal outcome following ICSI with assisted oocyte activation by calcium ionophore treatment

Mateizel

Verheyen

Velde

et al. 2018

J Assist Reprod Genet

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Section: Introductionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Obstetric and neonatal outcome following ICSI with assisted oocyte activation by calcium ionophore treatment

Mateizel

Verheyen

Velde

et al. 2018

J Assist Reprod Genet

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“…Neonatal and sociodemographic data were collected using a parental questionnaire [18]. To measure language development, the CELF was used.…”

Section: Methodsmentioning

confidence: 99%

Language Development of Three- to Twelve-Year-Old Twins Compared to Singletons

D’haeseleer

Geenens

Parmentier

et al. 2016

Folia Phoniatr Logop

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Objective: The language development of twins tends to lag behind in comparison to that of singletons. The purpose of this study was to compare expressive and receptive language skills of 3- to 12-year-old twins with singletons. Secondly, correlations between language differences between twins and singletons and age were investigated. Patients and Methods: Twenty-four twins with a mean age of 5.1 years participated in the study. The control group consisted of 24 singletons who were matched for gender and age. Language development was investigated using the Clinical Evaluation of Language Fundamentals. Results: Twins scored significantly lower for expressive and receptive language skills compared to singletons. Even when excluding preterm-born children, twins still scored significantly lower for expressive language skills. There was no correlation between age and language differences between twins and their matched singletons. Conclusion: Twins score lower for expressive and receptive language skills compared to singletons, and preterm birth cannot be regarded as the main cause for the language delay. The language delay in twins is rather mild but does not seem to decrease with increasing age.

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“…Additional measures are required when carrying ICSI for these couples. To overcome this inadequacy, AOA can be implemented but there is also an increasing requirement to avoid unnecessary AOA as the long term effects of these procedures need to be evaluated, despite several studies emphasizing safety of this procedure [Deemeh et al 2015;D'haeseleer et al 2014;Vanden Meerschaut et al 2014]. Therefore, certain criteria are required to select the correct candidate for AOA.…”

Section: Discussionmentioning

confidence: 99%

Relationship between phospholipase C-zeta, semen parameters, and chromatin status

Tavalaee

Kiani-Esfahani

Nasr-Esfahani

2017

Systems Biology in Reproductive Medicine

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The need for additional tests to complement basic sperm analysis in clinics is well appreciated. In this regard, a number of tests such as sperm DNA integrity test as a tool in diagnosis and treatment of infertility are suggested. But recent studies have focused on main sperm factors involved in oocyte activation such as phospholipase C-zeta (PLCζ) that initiate intracellular Ca signaling and embryogenesis. Therefore, this study aimed to investigate the relationship between PLCζ, basic semen parameters, sperm DNA fragmentation (SDF), and protamine deficiency in men with normal (n=32) and abnormal (n=23) semen parameters. Unlike SDF and protamine deficiency, as negative factors related to fertility, the mean value of PLCζ as positive factor related to infertility was significantly lower in men with abnormal semen parameters compared to men with normal semen parameters. Significant correlations were also observed between sperm concentration, motility, and abnormal morphology with the percentage of PLCζ positive spermatozoa. In addition, logistic regression analysis revealed that sperm morphology is more predictive than sperm motility and concentration for PLCζ presence. In addition, a statistically significant negative relationship was observed between the percentage of PLCζ positive spermatozoa and SDF. These findings suggested during ICSI, selection of sperm based on morphology has a profound effect on its ability to induce oocyte activation based on the likelihood of PLCζ expression. Therefore, assessment of PLCζ as an index for fertilization potential of a semen sample in men with severe teratozoospermia may define individuals who are candidates for artificial oocyte activation (AOA) and may avoid failed fertilization post ICSI.

show abstract

Language development of children born following intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)

Cited by 24 publications

References 27 publications

Obstetric and neonatal outcome following ICSI with assisted oocyte activation by calcium ionophore treatment

Obstetric and neonatal outcome following ICSI with assisted oocyte activation by calcium ionophore treatment

Language Development of Three- to Twelve-Year-Old Twins Compared to Singletons

Relationship between phospholipase C-zeta, semen parameters, and chromatin status

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