Language impairment in Parkinson's disease

Lewis, Fiona M.; Lapointe, Luc; Murdoch, Bruce E.; Chenery, Helen J.

doi:10.1080/02687039808249446

Cited by 142 publications

(57 citation statements)

References 28 publications

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“…Interestingly, the pattern of language deficits exhibited by the participants with left cerebellar lesions in the present study is similar to those reported in persons with other subcortical pathologies such as Parkinson's disease, multiple sclerosis, Huntington's disease and non-thalamic subcortical vascular lesions [18,[24][25][26] , suggesting that a common neural substrate based on frontal lobe disconnection may underly the language deficits observed in these groups. The findings of the present study support the proposal of Cook et al [4] that the basal ganglia, thalamus and cerebellum together may represent a symbiotic regulatory centre in relation to the mediation of complex lexico-semantic operations and language formulation which are presumably dependent on frontal lobe mechanisms.…”

Section: Discussionsupporting

confidence: 73%

Language Disorders Subsequent to Left Cerebellar Lesions: A Case for Bilateral Cerebellar Involvement in Language?

Murdoch

Whelan²

2007

Folia Phoniatr Logop

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Background: Crossed cerebello-cerebral diaschisis, reflecting a functional depression of supratentorial language areas due to reduced input via cerebello-cortical pathways, may represent the neuropathological mechanism responsible for language deficits associated with cerebellar pathology. Although it has been proposed that language is lateralized to the right cerebellar hemisphere, recent clinical and neuroimaging studies suggest that the cerebellum may bilaterally influence the regulation of language, with the left cerebellar hemisphere also contributing to the mediation of language via ipsilateral cerebello-cortical pathways. Aims: The aim of the study was to determine the effect of left primary cerebellar lesions on general as well as higher-level language function. Methods and Procedures: Linguistic profiles of a group of ten individuals with left primary cerebellar lesions were compared with those of a group of non-neurologically impaired controls matched for age, gender and level of education. Outcomes and Results: The findings confirmed that higher-level language deficits may result from left primary cerebellar lesions possibly as a consequence of ipsilateral cerebral diaschisis. Conclusions: The results challenge the notion of a right lateralized cerebellum and support a role for the left as well as the right cerebellar hemisphere in the regulation of language function.

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Section: Discussionsupporting

confidence: 73%

Language Disorders Subsequent to Left Cerebellar Lesions: A Case for Bilateral Cerebellar Involvement in Language?

Murdoch

Whelan²

2007

Folia Phoniatr Logop

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“…Impairments to semantic processing have also been identified in PD (Bocanegra et al, 2015;Lewis, Lapointe, Murdoch, & Chenery, 1998;Portin, Laatu, Revonsuo, & Rinne, 2000), including deficits to semantic inhibition (Arnott et al, 2010;Copland, Sefe, Ashley, Hudson, & Chenery, 2009) and alterations to automatic or controlled semantic priming (Angwin, Chenery, Copland, Murdoch, & Silburn, 2005Angwin et al, 2009;Arnott, Chenery, Murdoch, & Silburn, 2001;Arnott et al, 2011;Copland, 2003;Grossman et al, 2002). Thus, developing a better understanding of the nature and extent of semantic impairments in PD is critical to understanding language function and cognitive decline in this population.…”

Section: Introductionmentioning

confidence: 99%

A Neurophysiological Study of Semantic Processing in Parkinson’s Disease

Angwin

Dissanayaka

Moorcroft

et al. 2016

J Int Neuropsychol Soc

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Objectives: Cognitive-linguistic impairments in Parkinson's disease (PD) have been well documented; however, few studies have explored the neurophysiological underpinnings of semantic deficits in PD. This study investigated semantic function in PD using event-related potentials. Methods: Eighteen people with PD and 18 healthy controls performed a semantic judgement task on written word pairs that were either congruent or incongruent. Results: The mean amplitude of the N400 for new incongruent word pairs was similar for both groups, however the onset latency was delayed in the PD group. Further analysis of the data revealed that both groups demonstrated attenuation of the N400 for repeated incongruent trials, as well as attenuation of the P600 component for repeated congruent trials. Conclusions: The presence of N400 congruity and N400 repetition effects in the PD group suggests that semantic processing is generally intact, but with a slower time course as evidenced by the delayed N400. Additional research will be required to determine whether N400 and P600 repetition effects are sensitive to further cognitive decline in PD. (JINS, 2017, 23, 78-89)

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“…During the sentence writing task, this simplification was not necessary 5 because this design sets low demands on cognition (Small et al, 1997). Language production may rely on these cognitive abilities (Lewis et al, 1998). Indeed, language and 10 cognition interactions have been reported in PD patients.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of language production in Parkinson's disease using a cued sentence generation task

Vanhoutte¹,

Letter²,

Corthals³

et al. 2012

Clinical Linguistics & Phonetics

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The present study examined language production skills in Parkinson's disease (PD) patients. A unique cued sentence generation task was created in order to reduce demands on memory and attention. Differences in sentence production abilities according to disease severity and cognitive impairments were assessed. Language samples were obtained from 20 PD patients and 20 healthy control participants matched for age, sex and educational level. In addition, a cognitive test for verbal memory and resistance to cognitive interference was administered. Statistical comparisons revealed significant language changes in an advanced stage of the disease. Advanced PD patients showed a reduction in lexical diversity in notional verbs, which was absent in nouns. Cognitive dysfunctions such as impaired verbal memory are suggested to contribute to the typical noun/verb dissociation in PD patients. In addition, advanced PD patients produced more semantic perseverations, which may be related to set-switching problems. In conclusion, whether language disturbances in PD are the result of non-linguistic cognitive dysfunctions or reflect pure language deficits exacerbated by cognitive impairments, remains a matter of debate. However, the negative impact of cognitive dysfunctions may be important

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Language impairment in Parkinson's disease

Cited by 142 publications

References 28 publications

Language Disorders Subsequent to Left Cerebellar Lesions: A Case for Bilateral Cerebellar Involvement in Language?

Language Disorders Subsequent to Left Cerebellar Lesions: A Case for Bilateral Cerebellar Involvement in Language?

A Neurophysiological Study of Semantic Processing in Parkinson’s Disease

Quantitative analysis of language production in Parkinson's disease using a cued sentence generation task

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