Lanomax as a Drug in Cataract Treatment: A Case Study

Balashova, L. M.; Namiot, V. A.; Kolesnichenko, I. I.; Novoderyozhkin, V. V.; Udaltsov, S. N.

doi:10.1134/s0006350918040024

Cited by 10 publications

(10 citation statements)

References 3 publications

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“…Electrochemical inversion methods cannot, in principle, be used for continuous determinations because of the need for sequential stages of accumulation and dissolution; however, they are suitable for performing automatic serial analyzes during certain time intervals if suitable programming equipment is available. , Examples are software-controlled devices that use a stationary mercury drip electrode − and a rotating mercury film electrode. − …”

Section: Methodsmentioning

confidence: 99%

“…Earlier, for express diagnostics of biological objects using multisensory stripping voltammetry, we tested the method of early diagnosis of glaucoma, using blood serum . Further studies have shown the working capacity and effectiveness of the method, in particular, when analyzing a number of ophthalmic drugs: Visomitin and Lanosterol . An increase in the strength of the complex present in the background increases the height of the peak of the metal dissolution current and, accordingly, decreases its width. − Assessment of the dynamics of changes in their concentration in the lacrimal fluid over time must determine the effective dosage of newly developed analgesic ophthalmic drugs.…”

Section: Methodsmentioning

confidence: 99%

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Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations

Kolesnichenko

2023

ACS Omega

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For the effective dosage of newly developed ophthalmic drugs, an assessment of the dynamics of their concentration in lacrimal fluid over time is required. To express the detection and identification of drugs, new methods are needed that must meet numerous requirements, not the least of which are selectivity, speed, the absence of false-negative results, and costeffectiveness. The possibility of identifying anesthetics (sevoflurane) in lacrimal fluid has been studied using a new electrochemical method of multisensory inversion voltammetry in the electronic tongue and electronic nose format. The measurements were performed on a planar electrode, which is a three-electrode structure. The solution of the test system consisted of 0.05 M KCl, which contained the metal cations Zn 2+ , Cd 2+ , Pb 2+ , Co 2+ , and Hg 2+ at a concentration of 5 × 10 −5 M. It is shown that this method is effective for the determination of anesthetics, and the dynamics of changes in their concentration over time are examined. This study aimed to research the behavioral pharmacokinetics in the lacrimal fluid of the opioid drug sevoflurane in pediatric ophthalmology using multisensory stripping voltammetry in patients during strabismus correction surgery. The dynamics of changes in their concentrations over time were examined. After the instillation of the anesthetics in patients, their concentrations in the tear fluid remained unchanged within 10 min. The list of organic substances that can be determined by multisensory stripping voltammetry has been extended. The class of organic substances determined by the method of multisensory inversion voltammetry has been expanded.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations

Kolesnichenko

2023

ACS Omega

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“…The analyzer embodies a new approach using a solution containing various metal ions as an electrochemical testsystem, the ions being able interact with organic substances to form complex compounds [21][22][23][24][25][26][27][28][29][30][31]. All known E-tongue devices use a set of electrodes as sensors, therefore the reproducibility of characteristics of the multi-sensor systems is problematic, which affects the reliability and pattern recognition in a negative way.…”

Section: Methodsmentioning

confidence: 99%

“…Measurements are performed on a single indicator electrode, which has a significant advantage compared to multi-sensor methods using a range of electrodes. This method allows the identification of organic substances using a preliminary database.The effectiveness of this method has been shown for several ophthalmic medications: Visomitin, Betoptic, and Lanomax [27][28][29][30]. The concentration of Visomitin in the lacrimal fluid was measured based on a calibration relationship.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Tear Fluid for Evaluation on the Concentration of the Generic Anti-Glaucoma Drug Betoptik using Multisensory Stripping Voltammetry and Multivariate Statistics

Kolesnichenko¹,

Balashova²

2021

EPJ Web Conf.

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It is important to monitor the concentration of drugs after their instillation: this helps to find the right drug dosages. The proposed method is based on recognizing multidimensional images through the use of multidimensional statistics; the images are produced by multisensory electrochemical systems that provide reliable information about the tested objects. The measurements were carried out using a planar solid-state electrode. The test-system solution was a 0.05 М KCl solution, which contained the Zn2+, Cd2+, Рb2+, Cu2+ Со2+, and Hg2+ metal cations at the concentration of 5 10–5 M. A new electrochemical method for multisensory stripping voltammetry has been used to determine whether it is appropriate for determination of generic forms of the drug Betoptic, that is, Xonef, Betoftan, and Betalink EU in tear fluid. Measurements were carried out on a planar three-electrode interdigitated electrode. It has been shown that this method is effective for determination of the generics. The dynamics of changes in their concentrations over time were examined. After instillation of the generics in glaucoma patients, their concentrations in the Tear fluid remained unchanged within 12 h. The list of organic substances that can be determined by the method of multisensory stripping voltammetry has been extended.

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“…Moreover, Balashova et. al (2018) reported that lanosterol present in Lanomax can stabilize rapid progressive cataracts, making it possible for nonsurgical dissolution of human cataracts.…”

Section: Mass Spectra and Structures Of A) Chondrillasterol And B) Lamentioning

confidence: 99%

Phytochemical Screening of Fish Poison Tree, Barringtonia Asiatica Seed for Potential Biopesticidal Activity and Pharmaceutical Uses

Mangawang¹,

Cabatan²,

Zante³

et al. 2020

CLSU-IJST

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The leaves are locally used as vegetable food, herb, spice, and medication for backaches, sore joints, rheumatism, hernia, and diarrhea (Barwick, 2004). According to Stuart (2018), in the Philippines, leaves are heated and applied as topical remedy for stomachache. Similarly, Ravikumar et al. (2015) reported that the Nicobari tribe of India utilized leaves for the treatment of fractures, wounds, de-worming, and pain relief. The flowers are large pinkish-white, which give off a sickly-sweet smell to attract bats and moths, which pollinate them in return.

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Lanomax as a Drug in Cataract Treatment: A Case Study

Cited by 10 publications

References 3 publications

Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations

Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations

Analysis of Tear Fluid for Evaluation on the Concentration of the Generic Anti-Glaucoma Drug Betoptik using Multisensory Stripping Voltammetry and Multivariate Statistics

Phytochemical Screening of Fish Poison Tree, Barringtonia Asiatica Seed for Potential Biopesticidal Activity and Pharmaceutical Uses

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