Lanostane Triterpenes from Gloeophyllum odoratum and Their Anti-Influenza Effects

Grienke, Ulrike; Zwirchmayr, Julia; Peintner, Ursula; Urban, Ernst; Zehl, Martin; Schmidtke, Michaela; Rollinger, Judith M.

doi:10.1055/a-0690-9236

Cited by 10 publications

(4 citation statements)

References 34 publications

(59 reference statements)

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“…Epigotin has a strong inhibitory effect on influenza A1 virus FM1 by reducing susceptibility to the virus via mitochondrial anti-viral signaling (Luo et al, 2019 ). Polysaccharides prevent the influenza virus from attaching to host cell surfaces (Yang et al, 2012 ; Zhao et al, 2008 ); inhibit Hepatitis B virus (HBV) in vitro by reducing extracellular and intracellular DNA levels of HBsAg, HBeAg, and HBV in HepG2.2.15 cells (Yong and Aisa, 2011 ; Zhao and Aisa, 2012 ); and promote specific immunity, non-specific immunity, humoral immunity, or cellular immunity effects (Grienke et al, 2019 ). More detailed clinical applications and pharmacological activities of I. indigotica were systematically reviewed by Chen et al ( 2021a ).…”

Section: Clinical Applications and Pharmacological Activities Of I Indigoticamentioning

confidence: 99%

Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology

et al. 2021

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Isatis indigotica Fort. (Chinese woad) is a species with an ancient and well-documented history as an indigo dye and medicinal plant. It is often confused with Isatis tinctoria L. (European woad), a medicinal plant in Europe. Here, the differences between I. indigotica and I. tinctoria are systematically described. The usage development history, clinical applications and pharmacological activities, and chemical components of I. indigotica are also summarized. Lignans, indole alkaloids, and their corresponding derivatives have been identified as the major active ingredients of I. indigotica and are associated with anti-viral, anti-inflammatory, anti-cancer, and other health-promoting activities. Notable progress has been made in understanding the biosynthetic pathway and regulation mechanism of lignans and indole alkaloids in I. indigotica, the results from which should facilitate the process of targeted metabolic engineering or synthetic biology. Moreover, multiple biotechnology methods such as polyploid breeding and genetic engineering have been used with I. indigotica to result in, for example, greater yields, higher levels of bioactive component accumulation, and enhanced stress tolerance to salt, drought, and insects. Some issues require additional analyses, and suggestions for future research on I. indigotica are also discussed.

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Section: Clinical Applications and Pharmacological Activities Of I Indigoticamentioning

confidence: 99%

Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology

et al. 2021

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“…Among them, trametenolic acid B ( 59 ), the most active compound, displayed potent inhibitory activity against H3N2 (HK/68) and H1N1 (A/Jena/8178/09) with IC 50 values of 14.1 and 11.3 μM (CC 50 > 100 μM), respectively. In a plaque reduction assay, this compound bound to cell‐free viruses and neutralized their infectivity 72 …”

Section: Anti‐influenza Natural Products and Derivativesmentioning

confidence: 99%

Development of anti‐influenza agents from natural products

Zhang

Morris‐Natschke

Cheng

et al. 2020

Medicinal Research Reviews

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“…Central Europe, Asia and North America [17,65] Anti-influenza virus activity [17]; antioxidant [66] and anti-cancer activities [67]; Thrombin inhibition [68].…”

Section: Fruit Bodies Of Gloeophyllum Odoratum (Anise Mazegill)mentioning

confidence: 99%

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

et al. 2020

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Twenty natural remedies traditionally used against different inflammatory diseases were probed for their potential to suppress the expression of the inflammatory markers E-selectin and VCAM-1 in a model system of IL-1 stimulated human umbilical vein endothelial cells (HUVEC). One third of the tested extracts showed in vitro inhibitory effects comparable to the positive control oxozeaenol, an inhibitor of TAK1. Among them, the extract derived from the roots and rhizomes of Peucedanum ostruthium (i.e., Radix Imperatoriae), also known as masterwort, showed a pronounced and dose-dependent inhibitory effect. Reporter gene analysis demonstrated that inhibition takes place on the transcriptional level and involves the transcription factor NF-κB. A more detailed analysis revealed that the P. ostruthium extract (PO) affected the phosphorylation, degradation, and resynthesis of IκBα, the activation of IKKs, and the nuclear translocation of the NF-κB subunit RelA. Strikingly, early effects on this pathway were less affected as compared to later ones, suggesting that PO may act on mechanism(s) that are downstream of nuclear translocation. As the majority of cognate NF-κB inhibitors affect upstream events such as IKK2, these findings could indicate the existence of targetable signaling events at later stages of NF-κB activation.

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Lanostane Triterpenes from Gloeophyllum odoratum and Their Anti-Influenza Effects

Cited by 10 publications

References 34 publications

Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology

Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology

Development of anti‐influenza agents from natural products

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

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