Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review

Sangweni, Nonhlakanipho F.; Dludla, Phiwayinkosi V.; Mosa, Rebamang A.; Kappo, Abidemi Paul; Opoku, Andy R.; Müller, C.; Johnson, Rabia

doi:10.1007/s10741-018-9733-9

Cited by 8 publications

(3 citation statements)

References 85 publications

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“…Inflammatory cardiomyocyte signaling is associated with the overproduction of both cytosolic and mitochondrial ROS (33,34). Hyperglycemia is indeed a key known driver of oxidative stress and inflammation, thereby driving cardiac fibrosis and reduced cardiac function (35). Such myocardial inflammation can drive DCM development with NF-κB signaling within the cardiac tissue being a major driver of this disease progression (36).…”

Section: Discussionmentioning

confidence: 99%

Cyclocarya paliurus ethanol leaf extracts protect against diabetic cardiomyopathy in db/db mice via regulating PI3K/Akt/NF-κB signaling

Wang

Zheng

et al. 2020

Food & Nutrition Research

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Background: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to significant mortality. Cyclocarya paliurus is a tree, the leaves of which are often utilized to prevent and treat diabetes mellitus. Whether C. paliurus leaves can prevent or treat DCM, however, it remains to be formally assessed. The present study was therefore designed to assess the ability of C. paliurus to protect against DCM in db/db mice. Methods: Male wild-type (WT) and db/db mice were administered C. paliurus ethanol leaf extracts (ECL) or appropriate vehicle controls daily via gavage, and levels of blood glucose in treated animals were assessed on a weekly basis. After a 10-week treatment, the levels of cardiac troponin I (cTn-I), lactate dehydrogenase (LDH), creatine kinase MB (CK-MB), aspartate transaminase (AST), total triglycerides (TG), and total cholesterol (TC) in serum were measured. Activities of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 in heart tissues were detected. Hematoxylin-eosin (HE) and Masson staining were conducted. The protein expression that related with oxidative stress and inflammatory reaction was evaluated by Western blotting. Results: Compared with WT mice, the TG, TC, and blood glucose levels in db/db mice increased significantly, which were reduced by ECL treatment. Compared with WT mice, the levels of LDH, CK-MB, AST, and cTn-I in serum and MDA in heart tissues of db/db mice increased significantly. Activities of SOD, GSH-Px, and CAT in heart tissues of db/db mice decreased significantly. The levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6) in heart tissues of db/db mice increased remarkably. However, ECL treatment improved the above pathological changes significantly. ECL alleviated pathological injury and fibrosis in heart tissues of mice. Western blotting showed that ECL increased Bcl-2 level and decreased Bax, cle-caspase-3, and clecaspase-9 expression. Furthermore, ECL inhibited NF-κB nuclear translocation and increased PI3K and p-Akt expressions. Popular scientific summary • Cyclocarya paliurus ethanol leaf extract (ECL) is able to protect against the development of diabetic cardiomyopathy in db/db mice. • The protective efficacy of ECL is associated with antioxidant, antiapoptotic, and anti-inflammatory mechanisms. • ECL is able to inhibit the activation and nuclear localization of NF-κB via promoting PI3K/Akt signaling in db/db mice.

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Section: Discussionmentioning

confidence: 99%

Cyclocarya paliurus ethanol leaf extracts protect against diabetic cardiomyopathy in db/db mice via regulating PI3K/Akt/NF-κB signaling

Wang

Zheng

et al. 2020

Food & Nutrition Research

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“…Moreover, CPE can improve insulin level, glucose tolerance, and insulin sensitivity and reduce insulin resistance in DM mice [64] . Hyperglycemia is a known key driver of oxidative stress and inflammation, which lead to cardiac fibrosis and decreased cardiac function [65] . Wang et al proved that CPE can prevent structural and functional changes in the heart tissue of diabetic mice [66] .…”

Section: Antihyperglycemicmentioning

confidence: 99%

Triterpenoids from Cyclocarya paliurus: Structure, biosynthesis, biological activities

Xi,

Liu,

et al. 2024

Food Science and Human Wellness

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“…[156] Lanosteryl triterpenes isolated from Protorhus longifolia act as a cardioprotective agent in diabetic cardiomyopathy and ischemic heart diseases. [157] Periplogenin-3-O-Dglucopyranosyl-(1→6)-Dglucopyaranosyl-(1→4)-Dcymaropyranoside, isolated from A. marmelos, shows protective effects against DOX-induced cardiovascular morbidities and hepatotoxicity in rats. [158] Plant polyphenols are also used for the prevention of heart diseases.…”

Section: Cardioprotective Effectsmentioning

confidence: 99%

Untitled

Upadhyay¹

2021

IJGP

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The present review article explains antihyperlipidemic and cardioprotective effects of various plant natural products. These are antioxidants which found in vegetable oils, fruits, seeds, plant leaves, stem, and plant roots. This article emphasizes therapeutic potential of sulfur-containing compounds, anthraquinones, thiosulfinates and ajoenes, tricin, quercetin, Kaikasaponin III and tectorigenin, polyphenols, vitamins and minerals, flavonoid, and phenolics mainly naringenin; aglycone, flavanone (+)-catechin, (−)-epicatechin, and procyanidin B2, quercetin, kaempferol, myricetin, rutin, naringenin, catechin, fisetin, and gossypetin, thymol and carvacrol, ceramicine B (limonoid), ginsenoside Rb1 and Rb2, naphthalenic compounds 6-methoxysorigenin and its glycosides, acylates, madecassoside (terpenoids), Miroestrol (phytoestrogen), quercetin rutinoside (rutin), tournefolal, and tournefolic acids A and B. Few other compounds such as thiobarbituric acid, niacin, hederagenin monodesmosides, kalopanaxsaponin A (KPS-A) and sapindoside C, abietane and seco-abietane diterpenes, lycopene, Curcurbitacins A, B, C, D, E, I, J, K, and L, and Colocynthosides A and B were found active. For a healthy life regular intake of plant natural products or herbal diets significantly reduce the cardiovascular risks. Before use, well-designed clinical trials are essentially required to explore real efficacy and safety of these plant products. For management of cardiovascular risks lipid profile is highly needful at an earlier stage. In addition, microlevel biomolecular changes responsible for multiple morbidities affiliated to CVD diseases must be measured to find minor changes at an earlier stage.

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Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review

Cited by 8 publications

References 85 publications

Cyclocarya paliurus ethanol leaf extracts protect against diabetic cardiomyopathy in db/db mice via regulating PI3K/Akt/NF-κB signaling

Cyclocarya paliurus ethanol leaf extracts protect against diabetic cardiomyopathy in db/db mice via regulating PI3K/Akt/NF-κB signaling

Triterpenoids from Cyclocarya paliurus: Structure, biosynthesis, biological activities

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