Lansoprazole 15 mg Once Daily for 14 Days Is Effective for Treatment of Frequent Heartburn: Results of 2 Randomized, Placebo-Controlled, Double-Blind Studies

Abstract

During the 14-day treatment period in a population with frequent heartburn who were likely to select a medication without consulting a prescriber, lansoprazole 15 mg once daily showed rapid and sustained effectiveness throughout a 24-hour period and was well tolerated.

Knowledge and Usage Patterns of Folic Acid amongst Physician Assistant Students at the University of Texas Medical Branch at Galveston.

“…The mean percentage of 24-hour days without heartburn during 14 days of treatment was greater in subjects treated with lansoprazole than in placebo recipients (p<0.0001 vs. placebo for lansoprazole in each study) (Figure 2), with more subjects on lansoprazole reporting no heartburn on day one of treatment compared with placebo (15-mg group vs placebo, p≤0.0005; 30-mg group vs placebo, p=0.0004) [40]. Subjects treated with lansoprazole also experienced a higher mean percentage of nighttimes with no heartburn during the 14-day treatment period, compared with subjects on placebo (p<0.0001 for all doses vs placebo) (Figure 3) [41].…”

“…Results from three studies described demonstrated that oncedaily lansoprazole 15 mg was effective and had a good tolerability profile in the treatment of frequent, including nighttime, heartburn in a self-treating population. [40,41] The 15-mg dose of lansoprazole, the lowest effective dose for acid-related gastrointestinal disorder symptoms, was shown to be as effective as the 30-mg dose. [41].…”

“…Two recently published reports of three multicenter, doubleblind, randomized studies, involving almost 2000 subjects, examined the effects of lansoprazole on daytime and nighttime frequent heartburn in self-treating populations [40,41]. In two studies, published in a single report, adults with frequent heartburn (on two or more days per week for the past month) were randomized to receive lansoprazole 15 mg or placebo for 14 days [40].…”

“…Dose-response data indicate that the incidence of diarrhea is dosedependent, remaining at 5% or less with lansoprazole doses up to 30 mg [24]. In general, adverse events experienced by patients on lansoprazole 15 mg and 30 mg are mild and transient [40,41].…”

“…In two studies, published in a single report, adults with frequent heartburn (on two or more days per week for the past month) were randomized to receive lansoprazole 15 mg or placebo for 14 days [40]. In the third study, subjects had to have heartburn on at least two nights per week, and they were randomized to receive lansoprazole 15 mg, lansoprazole 30 mg, or placebo each morning for 14 days [41].…”