Lansoprazole, clarithromycin and metronidazole for seven days in <i>Helicobacter pylori</i> infection

Harris, Adam; Pryce, D. M.; Gabe, Simon; Karim, Q. N.; Walker, M M; Langworthy, H; Baron, J. H.; Misiewicz, J. J.

doi:10.1046/j.1365-2036.1996.100272000.x

Cited by 47 publications

(45 citation statements)

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“…Low-dose triple therapy with an antisecretory drug (7 days) Bouchard 49 Lerang 62 Thijs63 Miyaji 64 Harris 65 Moayyedi 66 Lind 67 for the discrepancies observed between studies with regard to the clinical relevance of metronidazole resistance. As mentioned earlier, it is possible that the E-test may overestimate the true rate of metronidazole resistance 48 . Moreover, correlations between different susceptibility testing methods have yielded suboptimal results for metronidazole, with only nine of 16 E-test MIC values being in the range of ± 1 dilution of those obtained by the agar dilution 56.…”

Section: Lerang 6 'mentioning

confidence: 96%

Antimicrobial resistance in Helicobacter pylori: a global overview

Glupczynski

1998

Helicobacter Pylori

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Section: Lerang 6 'mentioning

confidence: 96%

Antimicrobial resistance in Helicobacter pylori: a global overview

Glupczynski

1998

Helicobacter Pylori

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“…Some studies suggest that triple therapy consisting of a proton pump inhibitor (PPI), CLR, and a nitroimidazole is effective in eradicating H. pylori infection in patients with MET-resistant strains [6][7][8][9], whereas others show that MET resistance significantly decreases efficacy [10][11][12]. This discrepancy may be due to the lack of a standard method for determination of susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility-Guided vs. Empiric Retreatment of Helicobacter pylori Infection After Treatment Failure

et al. 2006

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Successful eradication of Helicobacter pylori after failure of standard triple therapy is difficult because of the higher resistance to metronidazole and clarithromycin. We evaluated the efficacy of susceptibility-guided vs. empiric retreatment for H. pylori after at least one treatment failure and determined the prevalence of posttreatment antibiotic resistance. Forty-nine patients in whom at least one treatment regimen for H. pylori eradication had failed underwent gastric biopsy and culture and were retreated according to the in vitro susceptibility results. Findings were compared with those for 49 control patients referred to our center for a (13)C-urea breath test. H. pylori eradication was assessed by urea breath test at least 6 weeks after retreatment in both groups. Susceptibility-guided retreatment was associated with better eradication rates than empiric treatment. The difference remained significant in stratified and multivariate analysis. Susceptibility-guided retreatment appears to be significantly more effective than empiric retreatment in eradicating H. pylori after at least one previous treatment failure.

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“…Alternative regimens should be used in such patients. As a regimen without amoxicillin, triple therapy with a proton pump inhibitor (PPI), clarithromycin and metronidazole (4) has been reported. However, the eradication rate associated with this triple therapy is low in patients infected with clarithromycinresistant strains of H. pylori (5).…”

Section: Introductionmentioning

confidence: 99%

Eradication of <i>H. pylori</i> Infection in Patients Allergic to Penicillin Using Triple Therapy with a PPI, Metronidazole and Sitafloxacin

et al. 2014

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Eradication of H. pylori in patients allergic to penicillin should be performed using regimens without penicillin derivatives. We treated a total of 28 patients allergic to penicillin with a proton pump inhibitor (PPI), metronidazole (250 mg bid) and sitafloxacin (100 mg bid) for one to two weeks. At four to eight weeks after the treatment, the patients underwent the [ 13 C]-urea breath test. The overall eradication rate was 100.0%. Mild adverse events were observed. Triple therapy with a PPI, metronidazole and sitafloxacin is well tolerated and effective for the eradication of H. pylori in patients allergic to penicillin.

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Lansoprazole, clarithromycin and metronidazole for seven days in Helicobacter pylori infection

Abstract: A 1-week course of lansoprazole 30 mg o.m., clarithromycin 250 mg b.d. and metronidazole 400 mg b.d. eradicates H. pylori in up to 86% of patients. It is of proven benefit in patients with pre-treatment metronidazole-resistant strains of H. pylori.

Cited by 47 publications

References 0 publications

Antimicrobial resistance in Helicobacter pylori: a global overview

Antimicrobial resistance in Helicobacter pylori: a global overview

Susceptibility-Guided vs. Empiric Retreatment of Helicobacter pylori Infection After Treatment Failure

Eradication of <i>H. pylori</i> Infection in Patients Allergic to Penicillin Using Triple Therapy with a PPI, Metronidazole and Sitafloxacin

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