1998
DOI: 10.1016/s0016-5085(98)81154-2
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Lansoprazole effectively suppresses intragastric acidity when administered via gastrostomy as intact granules in orange juice

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Cited by 12 publications
(24 citation statements)
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“…It was secured to the external end of the gastrostomy tube with adhesive tape so that the electrode was 2–3 cm from the internal bumper of the gastrostomy tube within the gastric lumen. As in previous studies, 2 , 3 we did not confirm the electrode position radiologically. However, we consistently obtained good pH recordings.…”
Section: Methodscontrasting
confidence: 71%
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“…It was secured to the external end of the gastrostomy tube with adhesive tape so that the electrode was 2–3 cm from the internal bumper of the gastrostomy tube within the gastric lumen. As in previous studies, 2 , 3 we did not confirm the electrode position radiologically. However, we consistently obtained good pH recordings.…”
Section: Methodscontrasting
confidence: 71%
“… 3 After 7 days of o.d. dosing, omeprazole 20 mg as intact granules suspended in orange juice raised mean intragastric pH from 1.8 to 4.9 ( P < 0.0001) in 14 gastrostomy patients 2 . Presumably, the orange juice maintained a sufficiently acidic milieu around the granules until they reached the duodenum where the enteric coating dissolved and the drugs were absorbed as usual.…”
Section: Discussionmentioning
confidence: 96%
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“…20 French) -so intact omeprazole granules can be flushed through a gastrostomy tube, and the efficacy of this method has been confirmed. 18 Administering Orally with Acidic Beverages If the patient with a nasogastric tube is able to swallow liquids they may be able to swallow the intact granules mixed with an acidic beverage to preserve the enteric coat. 19 ' 20 The beverage (e.g.…”
Section: Flushing Intact Granulesmentioning
confidence: 99%