Lansoprazole – Induce Black Hairy Tongue- A Case Report

Aryal, Eliz; Rajbhandari, M; Bhattarai, Shristi

doi:10.3126/njdvl.v15i1.18054

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Aryal et al reported a case of Lansoprazole induced BHT in 2017. 6 PPI induced BHT is possibly due to alteration of the pH of gastric acid in the stomach and a decrease in saliva production which may lead to defective desquamation of the dorsal surface of the tongue thereby accumulating a keratinized layer and allowing the growth of candida species and porphyrin producing chromogenic organisms in the oral flora giving the characteristic colour. Accumulation of keratinized layer causes hypertrophy and elongation of filiform papillae.…”

Section: Discussionmentioning

confidence: 99%

“…Smoking, consumption of heavy black tea or coffee, poor oral hygiene associated with HIV, malignancy, trigeminal neuralgia, and medications like antipsychotics, methyldopa, antidepressants, anticancer medicines and antibiotics have been reported to cause BHT. 6,7 The purpose of this article is to present a case of pantoprazole induced BHT, which has been rarely reported till date.…”

Section: Introductionmentioning

confidence: 99%

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Pantoprazole induced black hairy tongue: a case report

Krishnan,

Keloth,

2023

Int J Basic Clin Pharmacol

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Black hairy tongue (BHT) is characterized by abnormally hypertrophied and elongated filiform papillae, appearing as blackish discoloration on the dorsal surface of the tongue. BHT has been reported as an adverse drug reaction to different categories of drugs. However, pantoprazole induced BHT has been rarely reported. We present the case of a 42-year-old female, admitted in the surgery ward with postoperative wound infection, for which she was prescribed oral clarithromycin and pantoprazole. On the third day of starting medications, she complained of blackish discoloration on the dorsal surface of the tongue with an alteration of taste sensation, which was clinically and microscopically diagnosed as BHT. Suspecting BHT as an adverse drug reaction to pantoprazole, it was stopped, while clarithromycin was continued for the full course. She was also advised to scrape her tongue thrice daily, drink adequate fluids and maintain good oral hygiene. On the third day after stopping pantoprazole, black discoloration and alteration of taste sensation resolved completely. WHO-UMC causality assessment scale showed a ‘probable’ association of the adverse drug reaction with pantoprazole. Physicians should be aware of the possibility of BHT with the use of pantoprazole and that it completely resolves on stoppage of the drug, mechanical debridement and good oral hygiene.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pantoprazole induced black hairy tongue: a case report

Krishnan,

Keloth,

2023

Int J Basic Clin Pharmacol

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“…BHT is associated with predisposing factors like bad oral hygiene, excessive black tea / coffee consumption, general debilitation, xerostomia, male gender, older age, prolonged use of oxidizing mouthwashes, advanced cancer, HIV and graftversus-host disease 1 . Medications include antibiotics, corticosteroids, oxygenating mouth rinses, glycopyrrolate, lorazepam and psychotropic drugs 2,5,6 . Antibiotics may alter oral microbial flora leading to trapping of foreign material and overgrowth of chromogenic microorganisms 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Antibiotics may alter oral microbial flora leading to trapping of foreign material and overgrowth of chromogenic microorganisms 2 . The protective function of saliva is lost in xerostomia, predisposing to BHT 2,5 . It is difficult to point out which antibiotic was the cause of BHT as he has had two antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Black hairy tongue

Kumar

Ashwini

Perumal

et al. 2022

Sri Lanka J Child Health

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Black hairy tongue, Drug induced) Case reportAn 8-year-old boy presented with asymptomatic blackish discolouration on the tongue. One week prior, he was treated with co-amoxiclav and azithromycin for pneumonia for 5 days. Discolouration was noted to be gradually increasing. The child was not on any other medication / application on the tongue. A local examination showed black stained filiform papillae on the dorsum of the tongue (Figure 1).

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Bibliometric analysis of adverse drug reactions and pharmacovigilance research activities in Nepal

Shrestha

Danekhu

et al. 2020

Therapeutic Advances in Drug Safety

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Background: Bibliometric analyses have been used previously to study the measures of quality and impact of research performed in several health-related areas such as adverse drug reactions (ADRs) and pharmacovigilance (PV), etc. This method can assess the research performance of publications quantitatively and statistically. There is no evidence of bibilometric studies analyzing ADRs and PV from Nepal. Therefore, the present study aimed to assess scientific output on ADRs and PV-related research activities in Nepal using a bibliometric analysis of publications from 2004 January to December 2018, that is, 15 years. Methods: A systematic search was conducted in PubMed, Web of Science, Google Scholar, Scopus and Nepal Journal Online (NepJOL) databases. ‘Adverse Drug Reactions‘ or ‘ADRs‘ or ‘ADR‘ or ‘Adverse drug reaction‘ or ‘AE‘ or ‘Adverse Event‘ or ‘Drug-Induced Reaction‘ or ‘Pharmacovigilance‘ or ‘PV‘ and ‘Nepal‘. The search covered 15 years (January 2004 to December 2018) of study on ADRs and PV in Nepal. Only articles retrieved from databases were included, whereas published/unpublished drug bulletins, pharmacy newsletters and thesis were excluded. The articles thus retrieved were recorded, and thereafter analyzed. Word count code was used for the analysis of keywords used in the retrieved articles. Results: A total of 124 articles were retrieved, with the highest rate of publications in 2006 and 2007, with 16 papers each. Among the articles, 10 (8.1%) were published in Kathmandu University Medical Journal (KUMJ). Single papers were published in 38 different journals. Brief reports (1.6%), case reports (31.2%), case series (0.8%), education forums (0.8%), letters to the editor (5.6%), original research articles (41.9%), review articles (9.7%), short communications and short reports (8.1%) on ADRs and PV were recorded. Out of 124 papers, 52 (41.9%) were original research publications. The majority (74.1%) of research was done in the category of ADR incidence, types, prevention, and management, followed by policy and suggestions for strengthening national and regional pharmacovigilance centers of Nepal (14.5%). Conclusions: During the study years, there was an increase in scientific publications on drug safety. A total of 124 published articles were found during bibliometric analysis of ADRs and PV research activities in Nepal.

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Lansoprazole – Induce Black Hairy Tongue- A Case Report

Cited by 3 publications

References 9 publications

Pantoprazole induced black hairy tongue: a case report

Pantoprazole induced black hairy tongue: a case report

Black hairy tongue

Bibliometric analysis of adverse drug reactions and pharmacovigilance research activities in Nepal

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