Lansoprazole-Induced Acute Interstitial Nephritis

Eken, Joshua; Phadke, Gautam; Ahmed, Sumera; Mahale, Adit

doi:10.1097/smj.0b013e318191e77c

Cited by 6 publications

(1 citation statement)

References 2 publications

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“… 1 Subsequently, several published case reports and case series suggested a class effect of proton pump inhibitors (PPIs) (including omeprazole, pantoprazole, lansoprazole, rabeprazole, and esomeprazole) on the occurrence of acute interstitial nephritis. 2 , 3 , 4 , 5 , 6 Anecdotal case reports received by national drug safety authorities prompted regulators in several countries to urge caution when prescribing PPIs 7 , 8 , 9 , 10 , 11 , 12 ; however, despite these warnings, several studies have shown concerning and continuing levels of inappropriate prescribing of PPIs in both hospital and primary care settings. 13 , 14 , 15 , 16 …”

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A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use

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Parkin

Paul

et al. 2014

Kidney International

180

137

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The magnitude of the suspected increase in risk of acute interstitial nephritis among proton pump inhibitor users is uncertain. Here, we conducted a nested case-control study using routinely collected national health and drug dispensing data in New Zealand to estimate the relative and absolute risks of acute interstitial nephritis resulting in hospitalization or death in users of proton pump inhibitors. The cohort included 572,661 patients without a history of interstitial nephritis or other renal diseases who started a new episode of proton pump inhibitor use between 2005 and 2009. Cases had a first diagnosis after cohort entry of acute interstitial nephritis confirmed by hospital discharge letter or death record, and renal histology (definite, 46 patients), or discharge letter or death record only (probable, 26 patients). Ten controls, matched by birth year and sex, were randomly selected for each case. In the case-control analysis based on definite cases and their controls, the unadjusted matched odds ratio (95% confidence interval) for current versus past use of proton pump inhibitors was 5.16 (2.21–12.05). The estimate was similar when all cases (definite and probable) and their corresponding controls were analyzed, and when potential confounders were added to the models. The crude incidence rates and confidence intervals per 100,000 person-years were 11.98 (9.11–15.47) and 1.68 (0.91–2.86) for current and past use, respectively. Thus, current use of a proton pump inhibitor was associated with a significantly increased risk of acute interstitial nephritis, relative to past use.

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confidence: 99%

A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use

Blank

Parkin

Paul

et al. 2014

Kidney International

180

137

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Current awareness: Pharmacoepidemiology and drug safety

2009

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Gastrointestinal drugs

Blandizzi¹,

Scarpignato²

2011

Side Effects of Drugs Annual

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Lansoprazole-Induced Acute Interstitial Nephritis

Cited by 6 publications

References 2 publications

A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use

A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use

Current awareness: Pharmacoepidemiology and drug safety

Gastrointestinal drugs

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